Results 11 to 20 of about 35,556 (271)
Therapeutic SERPINs: Improving on Nature [PDF]
Frontiers in Cardiovascular Medicine, 2021 Serine proteases drive important physiological processes such as coagulation, fibrinolysis, inflammation and angiogenesis. These proteases are controlled by serine protease inhibitors (SERPINs) that neutralize their activity.
Coen Maas, Steven de Maat
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Serpins in the Caenorhabditis elegans genome [PDF]
Proteins: Structure, Function, and Genetics, 1999 Data mining in genome sequences can identify distant homologues of known protein families, and is most powerful if solved structures are available to reveal the three-dimensional implications of very dissimilar sequences. Here we describe putative serpin sequences identified with very high statistical significance in the Caenorhabditis elegans genome ...
James C. Whisstock +4 more
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Molecular Biology and Evolution, 2002 Members of the serpin (serine proteinase inhibitor) superfamily have been identified in higher multicellular eukaryotes (plants and animals) and viruses but not in bacteria, archaea, or fungi. Thus, the ancestral serpin and the origin of the serpin inhibitory mechanism remain obscure.
James A. Irving +5 more
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Necrosis and the Serpin Under't [PDF]
Developmental Cell, 2007 Caspase proteases play essential roles in apoptotic cell death, while other proteases are active in necrotic cell death. In a recent paper in Cell, Luke et al. (2007) present findings demonstrating that a gene believed to be a natural protease inhibitor may have a role in preventing necrosis.
Mary C. Abraham, Shai Shaham
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Serpins: the uncut version [PDF]
Structure, 1994 The structure of active antithrombin, the first active serpin to be solved, sheds new light on the conformational forms of this important class of inhibitor.
James Mottonen, Elizabeth J. Goldsmith
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Pre-clinical evaluation of antiproteases as potential candidates for HIV-1 pre-exposure prophylaxis
Frontiers in Reproductive Health, 2022 Previous studies on highly HIV-1-exposed, yet persistently seronegative women from the Punwami Sex Worker cohort in Kenya, have shed light on putative protective mechanisms, suggesting that mucosal immunological factors, such as antiproteases, could be ...
Carolina Herrera +7 more
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Journal of Translational Medicine, 2022 Background Helicobacter pylori (H. pylori) can disrupt the tight junctions between gastric epithelial cells and penetrate the intercellular spaces acting on epithelial cells, normal fibroblasts (NFs), and cancer-associated fibroblasts (CAFs), but their ...
Xueshu Chen +8 more
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Frontiers in Immunology, 2022 Phenoloxidase (PO)–catalyzed melanization is a vital immune response in insects for defense against pathogen infection. This process is mediated by clip domain serine proteases and regulated by members of the serpin superfamily. We here revealed that the
Jiayue Ji +6 more
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Frontiers in Immunology, 2023 Serpins are widely distributed and functionally diverse inhibitors of serine proteases. Ticks secrete serpins with anti-coagulation, anti-inflammatory, and immunomodulatory activities via their saliva into the feeding cavity to modulate host’s hemostatic
Adéla Chlastáková +8 more
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Lentinan improved the efficacy of vaccine against Trichinella spiralis in an NLRP3 dependent manner.
PLoS Neglected Tropical Diseases, 2020 There is an urgent need for the development of new, improved vaccine adjuvants against T. spiralis infection. Polysaccharides are effective, safe, and biodegradable as adjuvant.
Xuemin Jin +7 more
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