Serpin Signatures in Prion and Alzheimer’s Diseases
Molecular Neurobiology, 2022 Serpins represent the most broadly distributed superfamily of proteases inhibitors. They contribute to a variety of physiological functions and any alteration of the serpin-protease equilibrium can lead to severe consequences.
Marco Zattoni +14 more
semanticscholar +1 more source
Frontiers in Cardiovascular Medicine, 2021 Plasminogen activator inhibitor 1 (PAI-1) is a member of the serine protease inhibitor (serpin) superfamily. PAI-1 is the principal inhibitor of the plasminogen activators, tissue plasminogen activator (tPA), and urokinase-type plasminogen activator (uPA)
G. Morrow, C. Whyte, N. Mutch
semanticscholar +1 more source
Journal of Nanobiotechnology, 2022 Chronic metabolic diseases such as diabetes are characterized by delayed wound healing and a dysregulation of the inflammatory phase of wound repair. Our study focuses on changes in the payload of extracellular vesicles (EVs) communicating between immune
D. Park +6 more
semanticscholar +1 more source
The Role of Proteases and Serpin Protease Inhibitors in β-Cell Biology and Diabetes
Biomolecules, 2022 Regulation of the equilibrium between proteases and their inhibitors is fundamental to health maintenance. Consequently, developing a means of targeting protease activity to promote tissue regeneration and inhibit inflammation may offer a new strategy in
Yury Kryvalap, J. Czyzyk
semanticscholar +1 more source
An antibody raised against a pathogenic serpin variant induces mutant-like behaviour in the wild-type protein. [PDF]
, 2015 A monoclonal antibody (mAb) that binds to a transient intermediate may act as a catalyst for the corresponding reaction; here we show this principle can extend on a macro-molecular scale to the induction of mutant-like oligomerisation in a wild-type ...
Faull, SV +7 more
core +4 more sources
RNAi-mediated knockdown of serine protease inhibitor genes increases the mortality of Plutella xylostella challenged by destruxin A. [PDF]
PLoS ONE, 2014 Destruxin A is a mycotoxin that is secreted by entomopathogenic fungi which has a broad-spectrum insecticidal effect. Previous transcript and protein profiling analysis showed that destruxin A has significant effects on the expression of serine protease ...
Pengfei Han +6 more
doaj +1 more source
Molecular identification, characterization, and expression analysis of a serine protease inhibitor gene from cotton bollworm, Helicoverpa armigera (Lepidoptera: Noctuidae) [PDF]
Brazilian Journal of Biology, 2020 Serine protease inhibitors (serpins), a superfamily of protease inhibitors, are known to be involved in several physiological processes, such as development, metamorphosis, and innate immunity.
Muhammad Shakeel
doaj +1 more source
Overview of serpin B9 and its roles in cancer (Review).
Oncology Report, 2021 Serine proteinase inhibitor B9 (serpin B9) is a member of the serine protease inhibitor superfamily, which is widely found in animals, plants and microorganisms.
Wenjun Wang +5 more
semanticscholar +1 more source
Pre-clinical evaluation of antiproteases as potential candidates for HIV-1 pre-exposure prophylaxis
Frontiers in Reproductive Health, 2022 Previous studies on highly HIV-1-exposed, yet persistently seronegative women from the Punwami Sex Worker cohort in Kenya, have shed light on putative protective mechanisms, suggesting that mucosal immunological factors, such as antiproteases, could be ...
Carolina Herrera +7 more
doaj +1 more source
Lentinan improved the efficacy of vaccine against Trichinella spiralis in an NLRP3 dependent manner.
PLoS Neglected Tropical Diseases, 2020 There is an urgent need for the development of new, improved vaccine adjuvants against T. spiralis infection. Polysaccharides are effective, safe, and biodegradable as adjuvant.
Xuemin Jin +7 more
doaj +1 more source