Results 21 to 30 of about 35,556 (271)
Interaction of subtilisins with serpins [PDF]
Protein Science, 1996 AbstractSerpins are well‐characterized inhibitors of the chymotrypsin family serine proteinases. We have investigated the interaction of two serpins with members of the subtilisin family, proteinases that possess a similar catalytic mechanism to the chymotrypsins, but a totally different scaffold.
Philip A. Pemberton +4 more
openaire +3 more sources
Serpins : form, function and dysfunction [PDF]
, 2013 The serpin superfamily of serine protease inhibitors is one of the most ubiquitous and successful classes of inhibitors in the living world. Their unique mechanism of suicide inhibition has led to much research and several important discoveries.
Cassar, Nicholas J., Hunter, Gary J.
core +1 more source
Serpins Are Getting Hotter [PDF]
Structure, 2003 AbstractProtease inhibitors of the serpin family require thermodynamic instability for their mechanism of inhibition, and a recent paper from Irving and colleagues demonstrates the structural basis for how a serpin from a bacterial thermophile deals with life at elevated temperature.
Guy S. Salvesen, Fiona L. Scott
openaire +2 more sources
Serine Protease Inhibitors Restrict Host Susceptibility to SARS-CoV-2 Infections
mBio, 2022 The coronavirus disease 2019, COVID-19, is a complex disease with a wide range of symptoms from asymptomatic infections to severe acute respiratory syndrome with lethal outcome. Individual factors such as age, sex, and comorbidities increase the risk for
Ebba Rosendal +14 more
doaj +1 more source
Deciphering the phylogenetic history of neuroserpin orthologs across metazoans by analysis of synteny and rare genomic characters [PDF]
, 2008 The superfamily of serine proteinase inhibitors (serpins) is involved in wide arrays of fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesis, inflammation and tumor suppression. The average protein
Abhishek Kumar, Hermann Ragg
core +2 more sources
An antibody raised against a pathogenic serpin variant induces mutant-like behaviour in the wild-type protein. [PDF]
, 2015 A monoclonal antibody (mAb) that binds to a transient intermediate may act as a catalyst for the corresponding reaction; here we show this principle can extend on a macro-molecular scale to the induction of mutant-like oligomerisation in a wild-type ...
Faull, SV +7 more
core +4 more sources
JACC: Basic to Translational Science, 2017 Low-density lipoprotein receptor–related protein-1 (LRP1) is a ubiquitous membrane receptor functioning as a scavenger and regulatory receptor, inducing anti-inflammatory and prosurvival signals. Based on the known structure–activity of the LRP1 receptor
Stefano Toldo, PhD +9 more
doaj +1 more source
Inhibition of melanization by serpin-5 and serpin-9 promotes baculovirus infection in cotton bollworm Helicoverpa armigera. [PDF]
PLoS Pathogens, 2017 Melanization, an important insect defense mechanism, is mediated by clip-domain serine protease (cSP) cascades and is regulated by serpins. Here we show that proteolytic activation of prophenoloxidase (PPO) and PO-catalyzed melanization kill the ...
Chuanfei Yuan +7 more
doaj +1 more source
Delving into Vertebrate Serpins for Understanding their Evolution [PDF]
, 2009 The superfamily of serine proteinase inhibitors (serpins) is involved in an array of fundamental biological processes such as blood coagulation, cell differentiation, cell migration, complement activation, embryo implantation, fibrinolysis, angiogenesis,
Abhishek Kumar
core +2 more sources
Frontiers in Microbiology, 2017 During parasite infection, serine protease inhibitors secreted by parasites play important roles in suppressing host defenses. However, the mechanism of immune regulation is unclear.
Ning Xu +9 more
doaj +1 more source