Results 31 to 40 of about 43,231 (331)
Toxins, 2021 Hemostatic disorders are caused either by platelet-related dysfunctions, defective blood coagulation, or by a combination of both, leading to an increased susceptibility to cardiovascular diseases (CVD) and other related illnesses. The unique specificity
Hajer Aounallah +8 more
doaj +1 more source
Molecular Biology and Evolution, 2002 Members of the serpin (serine proteinase inhibitor) superfamily have been identified in higher multicellular eukaryotes (plants and animals) and viruses but not in bacteria, archaea, or fungi. Thus, the ancestral serpin and the origin of the serpin inhibitory mechanism remain obscure.
James A, Irving +5 more
openaire +2 more sources
A Comprehensive Phylogenetic Analysis of the Serpin Superfamily
bioRxiv, 2020 Serine protease inhibitors (serpins) are found in all kingdoms of life and play essential roles in multiple physiological processes. Owing to the diversity of the superfamily, phylogenetic analysis is challenging and prokaryotic serpins have been ...
M. Spence +4 more
semanticscholar +1 more source
Inflammasomes: caspase-1-activating platforms with critical roles in host defense [PDF]
, 2011 Activation of the inflammatory cysteine protease caspase-1 in inflammasome complexes plays a critical role in the host response to microbial infections.
Lieselotte eVande Walle +3 more
core +2 more sources
JACC: Basic to Translational Science, 2017 Low-density lipoprotein receptor–related protein-1 (LRP1) is a ubiquitous membrane receptor functioning as a scavenger and regulatory receptor, inducing anti-inflammatory and prosurvival signals. Based on the known structure–activity of the LRP1 receptor
Stefano Toldo, PhD +9 more
doaj +1 more source
Multiple origins of green coloration in frogs mediated by a novel biliverdin-binding serpin
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance Green coloration of vertebrates is normally attributed to pigments and structural components inside skin chromatophores cells. However, these components do not account for the vivid blue-green colors of hundreds of species of frogs with ...
C. Taboada +12 more
semanticscholar +1 more source
An antibody that prevents serpin polymerisation acts by inducing a novel allosteric behavior [PDF]
, 2016 Serpins are important regulators of proteolytic pathways with an antiprotease activity that involves a conformational transition from a metastable to a hyperstable state. Certain mutations permit the transition to occur in the absence of a protease; when
Faull, Sarah V. +14 more
core +1 more source
Delving into Vertebrate Serpins for Understanding their Evolution [PDF]
, 2009 The superfamily of serine proteinase inhibitors (serpins) is involved in an array of fundamental biological processes such as blood coagulation, cell differentiation, cell migration, complement activation, embryo implantation, fibrinolysis, angiogenesis,
Abhishek Kumar
core +2 more sources
Frontiers in Microbiology, 2017 During parasite infection, serine protease inhibitors secreted by parasites play important roles in suppressing host defenses. However, the mechanism of immune regulation is unclear.
Ning Xu +9 more
doaj +1 more source
Expression of SERPINA3s in cattle: focus on bovSERPINA3-7 reveals specific involvement in skeletal muscle [PDF]
Open Biology, 2015 α1-Antichymotrypsin is encoded by the unique SERPINA3 gene in humans, while it is encoded by a cluster of eight closely related genes in cattle. BovSERPINA3 proteins present a high degree of similarity and significant divergences in the reactive centre ...
Antoine Péré-Brissaud +9 more
doaj +1 more source