Results 71 to 80 of about 24,818 (268)
Scientific Reports, 2023 As a leading cause of chronic kidney disease, diabetic kidney disease (DKD) involves insidious but progressive impairments of renal tubules, and is associated with premature renal aging. The underlying pathomechanisms remain elusive. Post hoc analyses of
Bo Han Chen +3 more
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Ecotin: A versatile protease inhibitor of bacteria and eukaryotes
Frontiers in Microbiology, 2023 Serine protease inhibitors are a large family of proteins involved in important pathways and processes, such as inflammatory responses and blood clotting.
Frédéric De Meyer +2 more
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Complexity of the Ruminococcus flavefaciens FD-1 cellulosome reflects an expansion of family-related protein-protein interactions [PDF]
, 2017 This work was supported in part by the European Union, Area NMP.2013.1.1–2: Self-assembly of naturally occurring nanosystems: CellulosomePlus Project number: 604530, and by the EU Seventh Framework Programme (FP7 2007–2013) under the WallTraC project ...
Alves, Victor D +17 more
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Viral SERPINS—A Family of Highly Potent Immune-Modulating Therapeutic Proteins
Biomolecules, 2023 Serine protease inhibitors, SERPINS, are a highly conserved family of proteins that regulate serine proteases in the central coagulation and immune pathways, representing 2–10% of circulating proteins in the blood.
Kyle Varkoly +5 more
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Control of granzymes by serpins [PDF]
Cell Death & Differentiation, 2009 Although proteolysis mediated by granzymes has an important role in the immune response to infection or tumours, unrestrained granzyme activity may damage normal cells. In this review, we discuss the role of serpins within the immune system, as specific regulators of granzymes. The well-characterised human granzyme B-SERPINB9 interaction highlights the
Phillip I. Bird, Dion Kaiserman
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Inflammation-Involved Proteins in Blood Serum of Cataract Patients—A Preliminary Study
Biomedicines, 2023 Approximately 50% of all global blindness is caused by cataract in adults aged ≥50 years. The mechanisms of the disease are most arguably related to a redox imbalance and inflammation; therefore, the aim of the study was to evaluate the processes ...
Paweł Sutkowy +3 more
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Design and characterization of an APC-specific serpin for the treatment of hemophilia.
Blood, 2017 Hemophilia is a bleeding disorder caused by deficiency in factors VIII or IX, the two components of the intrinsic Xase complex. Treatment with replacement factor can lead to the development of inhibitory antibodies, requiring the use of bypassing agents ...
S. Polderdijk +5 more
semanticscholar +1 more source
Pharmaceutics, 2023 The incidence of empyema is increasing and associated with a mortality rate of 20% in patients older than 65 years. Since 30% of patients with advanced empyema have contraindications to surgical treatment, novel, low-dose, pharmacological treatments are ...
Galina Florova +10 more
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Molecular identification, characterization, and expression analysis of a serine protease inhibitor gene from cotton bollworm, Helicoverpa armigera (Lepidoptera: Noctuidae) [PDF]
Brazilian Journal of Biology, 2020 Serine protease inhibitors (serpins), a superfamily of protease inhibitors, are known to be involved in several physiological processes, such as development, metamorphosis, and innate immunity.
Muhammad Shakeel
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Structural aspects of serpin inhibition [PDF]
FEBS Letters, 1994 The essential roles of proteins of the serpin family in many physiological processes, along with new discoveries of their unique folding properties, have attracted intense interest in recent years. Many serpins display unusual mobile behavior attributed to rearrangements of α‐helical or β‐sheet domains, whereby large scale transitions accompany a ...
Andreas Schulze +3 more
openaire +3 more sources