Results 71 to 80 of about 43,231 (331)

Inhibition of yes-associated protein suppresses brain metastasis of human lung adenocarcinoma in a murine model. [PDF]

, 2018
Yes-associated protein (YAP) is a main mediator of the Hippo pathway and promotes cancer development and progression in human lung cancer. We sought to determine whether inhibition of YAP suppresses metastasis of human lung adenocarcinoma in a murine ...
Chan, Geraldine, Dai, Yuyuan, Hsu, Ping-Chih, Huang, Zhen, Jablons, David M, Liu, Shu, Miao, Jinbai, Urisman, Anatoly, Xu, Zhidong, Yang, Cheng-Ta, Yang, Yi-Lin, Yeh, Che-Chung, You, Joanna, You, Liang   +13 more
core   +1 more source

Investigation of a Serine Protease Inhibitor Active in the Infectious Stage of the Human Liver Fluke Opisthorchis viverrini

Pathogens
Serine protease inhibitors (serpins) participate in the regulation of inflammation, blood coagulation, and complement activation in humans. This research aimed to identify and characterize such inhibitors of the human liver fluke Opisthorchis viverrini ...
Rosnanee Salang, Wansika Phadungsil, Amornrat Geadkaew-Krenc, Rudi Grams   +3 more
doaj   +1 more source

Characterization and functional analysis of the serpin-10 gene from oak silkworm, Antheraea pernyi (Lepidoptera: Saturniidae)

European Journal of Entomology, 2017
Serpin is a broadly distributed superfamily of proteins that have a crucial role in regulating various immune reactions. Herein we identified a serpin-10 gene from Antheraea pernyi that encodes a 1557 amino acid residue protein with a predicted molecular
Saima KAUSAR, Cen QIAN, Muhammad Nadeem ABBAS, Bao-Jian ZHU, Ya LIU, Lei WANG, Guo-Qing WEI, Yu SUN, Chao-Liang LIU   +8 more
doaj   +1 more source

Serpin E1 mediates the induction of renal tubular degeneration and premature senescence upon diabetic insult

Scientific Reports, 2023
As a leading cause of chronic kidney disease, diabetic kidney disease (DKD) involves insidious but progressive impairments of renal tubules, and is associated with premature renal aging. The underlying pathomechanisms remain elusive. Post hoc analyses of
Bo Han Chen, Xiao Qing Lu, Xian Hui Liang, Pei Wang   +3 more
doaj   +1 more source

Angiotensinogen and the Modulation of Blood Pressure

Frontiers in Cardiovascular Medicine, 2021
The angiotensin peptides that control blood pressure are released from the non-inhibitory plasma serpin, angiotensinogen, on cleavage of its extended N-terminal tail by the specific aspartyl-protease, renin. Angiotensinogen had previously been assumed to
Zimei Shu, Jiahui Wan, Randy J. Read, Robin W. Carrell, Aiwu Zhou   +4 more
doaj   +1 more source

A Mussel‐Inspired Bioadhesive Patch to Selectively Kill Glioblastoma Cells

Advanced Science, EarlyView.
An innovative mussel‐inspired bioadhesive patch has been developed for post‐surgical glioblastoma treatment. The patch, which adheres strongly in biological environments, releases a localized treatment. This treatment, acting via reactive oxygen species, shows specific toxicity to glioblastoma cells.
Jose Bolaños‐Cardet, Sara Pugliese, Jordi Bruna, Daniel Ruiz‐Molina, Salvio Suárez‐García, Victor J. Yuste   +5 more
wiley   +1 more source

Targeting the PAI-1 Mechanism with a Small Peptide Increases the Efficacy of Alteplase in a Rabbit Model of Chronic Empyema

Pharmaceutics, 2023
The incidence of empyema is increasing and associated with a mortality rate of 20% in patients older than 65 years. Since 30% of patients with advanced empyema have contraindications to surgical treatment, novel, low-dose, pharmacological treatments are ...
Galina Florova, Christian J. De Vera, Rebekah L. Emerine, René A. Girard, Ali O. Azghani, Krishna Sarva, Jincy Jacob, Danna E. Morris, Mignote Chamiso, Steven Idell, Andrey A. Komissarov   +10 more
doaj   +1 more source

Serpin functions in host-pathogen interactions

PeerJ, 2018
Serpins are a broadly distributed superfamily of protease inhibitors that are present in all kingdoms of life. The acronym, serpin, is derived from their function as potent serine proteases inhibitors.
J. Bao, G. Pan, M. Poncz, Junhong Wei, Maoshuang Ran, Zeyang Zhou   +5 more
semanticscholar   +1 more source

Gene expression patterns following unilateral traumatic brain injury reveals a local pro-inflammatory and remote anti-inflammatory response. [PDF]

, 2013
BackgroundTraumatic brain injury (TBI) results in irreversible damage at the site of impact and initiates cellular and molecular processes that lead to secondary neural injury in the surrounding tissue.
Ford, Byron D, Ford, Gregory D, Gates, Alicia S, Laplaca, Michelle C, Surles-Zeigler, Monique C, White, Todd E   +5 more
core   +2 more sources

Increased Blood Flow and Tendon Swelling Precedes Vascular Expansion and Tissue Matrix Changes In Early Human Tendinopathy: A Potential Window for Superior Treatment Response

Advanced Science, EarlyView.
Human participants with early‐ or chronic‐stage tendinopathy and healthy controls are investigated using ultrasound Doppler, 3T and 7T MRI, and tendon biopsies. Tendon swelling and hyperperfusion are evident early, while vascular growth and extracellular matrix changes are most pronounced in chronic tendinopathy. Early intervention may provide superior
Max F. R. Merkel, Nikolaj M. Malmgaard‐Clausen, Marius Lendal, Hartwig R. Siebner, René B. Svensson, Stephanie G. Dakin, Marcus Krüger, Luisa Schmidt, Jakob Agergaard, Ching‐Yan Chloé Yeung, S. Peter Magnusson, Michael Kjaer   +11 more
wiley   +1 more source