Results 91 to 100 of about 11,907 (228)

Structural characterization and conformational dynamics of alpha-1 antitrypsin pathogenic variants causing alpha-1-antitrypsin deficiency

Frontiers in Molecular Biosciences, 2022
Background: Alpha-1 antitrypsin deficiency (A1ATD) is a progressive lung disease caused by inherited pathogenic variants in the SERPINA1 gene. However, their actual role in maintenance of structural and functional characteristics of the corresponding α-1
Noor Ahmad Shaik, Noor Ahmad Shaik, Najla Bint Saud Al-Saud, Thamer Abdulhamid Aljuhani, Kaiser Jamil, Huda Alnuman, Deema Aljeaid, Nasreen Sultana, Ashraf AbdulRahman El-Harouni, Zuhier Ahmed Awan, Zuhier Ahmed Awan, Ramu Elango, Ramu Elango, Babajan Banaganapalli, Babajan Banaganapalli   +14 more
doaj   +1 more source

Membralin Assembles a MAN1B1–VCP Complex to Target Foreign Glycoproteins from the Endoplasmic Reticulum to Lysosomes for Degradation

Advanced Science, Volume 13, Issue 9, 13 February 2026.
This study identifies Membralin as an ER‐phagy receptor that recruits MAN1B1 and VCP to form a selective ERLAD complex. By sensing dense N‐glycan clusters on viral fusion glycoproteins, this ubiquitin‐independent pathway directs SARS‐CoV‐2 spike, Ebola GP, influenza HA, and HIV‐1 Env to lysosomal degradation, thereby limiting viral infectivity ...
Jing Zhang, Xiaoran Lu, Sunan Li, Tao Wang, Iqbal Ahmad, Yong‐Hui Zheng   +5 more
wiley   +1 more source

Influence of SERPINA1 Gene Polymorphisms on Anemia and Chronic Obstructive Pulmonary Disease

Journal of the Renin-Angiotensin-Aldosterone System, 2022
Background. Anemia is one of the predominant hematological conditions, whereas chronic obstructive pulmonary disease (COPD) is a predominant respiratory disease. These two diseases were found to be interlinked, but the physiological pathways are still unclear. Aim.
Thangavelu Sangeetha, Tajuddin Nargis Begum, Balasubramanian Balamuralikrishnan, Meyyazhagan Arun, Kannan R. R. Rengasamy, Natchiappan Senthilkumar, Shanmugam Velayuthaprabhu, Muthukrishnan Saradhadevi, Palanisamy Sampathkumar, Arumugam Vijaya Anand   +9 more
openaire   +2 more sources

An antibody that prevents serpin polymerisation acts by inducing a novel allosteric behavior [PDF]

, 2016
Serpins are important regulators of proteolytic pathways with an antiprotease activity that involves a conformational transition from a metastable to a hyperstable state. Certain mutations permit the transition to occur in the absence of a protease; when
Faull, Sarah V., Haq, Imran, Heyer Chauhan, Narinder, Irving, James A., Jagger, Alistair M., Kay, Christopher W. M., Liedtke, Maximilian, Lomas, David A., MIRANDA BANOS, MARIA ELENA, Motamedi Shad, Neda, Nanda, Arjun Scott, Ordóñez, Adriana, Perez, Juan, Salvadori, Enrico, Wort, Joshua L.   +14 more
core   +1 more source

Genetic variants underlying precancerous conditions of hepatocellular carcinoma

International Journal of Cancer, Volume 158, Issue 3, Page 488-502, 1 February 2026.
Abstract Hepatocellular carcinoma (HCC) is the most common form of liver cancer, accounting for 80% of cases worldwide. While chronic hepatitis B and C infections remain primary risk factors, emerging evidence highlights the increasing contributions of metabolic dysfunction‐associated steatotic liver disease (MASLD) and alcohol‐associated liver disease
Jonathan Jaime G. Guerrero, Paolo C. Encarnacion, Mark Angelo S. del Rosario, Matthew Aldren S. Ora, Jiayan Zhou, Kin Israel Notarte, Wan‐Chun Li, Ching‐Wen Chang   +7 more
wiley   +1 more source

Diagnosing Alpha-1-Antitrypsin Deficiency Using A PCR/Luminescence-Based Technology

International Journal of COPD, 2019
Martina Veith,1 Andreas Klemmer,1 Iker Anton,2 Rachid El Hamss,2 Noelia Rapun,2 Sabina Janciauskiene,3 Viktor Kotke,1 Christian Herr,4 Robert Bals,4 Claus Franz Vogelmeier,1 Timm Greulich1 1Department of Medicine, Pulmonary and Critical Care Medicine ...
Veith M, Klemmer A, Anton I, El Hamss R, Rapun N, Janciauskiene S, Kotke V, Herr C, Bals R, Vogelmeier CF, Greulich T   +10 more
doaj  

Innate immune response is differentially dysregulated between bipolar disease and schizophrenia [PDF]

, 2015
Articles in PressSchizophrenia (SZ) and bipolar disorder (BD) are severe psychiatric conditions with a neurodevelopmental component. Genetic findings indicate the existence of an overlap in genetic susceptibility across the disorders. Also, image studies
Barreta, Luiz André Nardin, Baumont, Angelica de, Belmonte-de-Abreu, Paulo, Brentani, Helena, Carraro, Dirce Maria, Filho, Carlos Alberto Moreira, Fiorini, Alex, Lima, Leandro, Maschietto, Mariana, Olivieri, Eloisa Helena, Palha, Joana Almeida   +10 more
core   +1 more source

Tissue‐Derived Extracellular Vesicles Define Diagnostic Biomarkers for Renal Cell Carcinoma

Journal of Extracellular Vesicles, Volume 15, Issue 2, February 2026.
Tissue‐derived EVs reveal renal cell carcinoma subtype biomarkers (NDUFA4L2/VEGFA/APOC1). Validated in urinary EVs (AUC 0.92), these markers originate from cancer cells and tumour‐associated macrophages via scRNA‐seq, enabling non‐invasive diagnosis and mechanistic insights into RCC progression.
Xinrui Wu, Jiale Zhou, Chen Jiang, Wenjin Chen, Zehong Peng, Tianyang Wu, Yang Ge, Xinxing Du, Cong Hu, Xiaorong Wu, Jiwei Huang, Jin Zhang, Xingang Cui, Wei Xue, Yonghui Chen, Liang Dong   +15 more
wiley   +1 more source

Development and characterization of a new human hepatic cell line [PDF]

, 2015
The increasing demand and hampered use of primary human hepatocytes for research purposes have urged scientists to search for alternative cell sources, such as immortalized hepatic cell lines.
Berx, Geert, De Craene, Bram, De Kock, Joey, Ramboer, Eva, Rogiers, Vera, Vanhaecke, Tamara, Vinken, Mathieu   +6 more
core   +3 more sources

Increased Risk of Cholesteatoma in Individuals With Alpha‐1 Antitrypsin Deficiency: A Cohort Study

The Laryngoscope, Volume 136, Issue 2, Page 955-960, February 2026.
Patients with AATD had a 3.6‐fold increased risk of cholesteatoma surgery (HR: 3.62) compared to controls. These findings suggest that AATD may contribute to the development of cholesteatoma. ABSTRACT Objective To estimate the risk of cholesteatoma in patients with alpha‐1 antitrypsin deficiency (AATD) compared to the general population using time‐to ...
Abdulla Ali, Helene Andresen Ravn, Morten Dahl, Bjarki Ditlev Djurhuus   +3 more
wiley   +1 more source