Results 101 to 110 of about 11,907 (228)
bioRxivAlpha-1 antitrypsin deficiency (AATD) is a rare genetic disorder caused by accumulation of misfolded α-1 antitrypsin within hepatocytes. AATD patients are prone to develop liver disease that remains undiagnosed until the late stages of the disease.
Regina A Oshins +9 more
semanticscholar +1 more source
Modified serpinA1 as risk marker for Parkinson’s disease dementia: Analysis of baseline data [PDF]
Scientific Reports, 2016 AbstractEarly detection of dementia in Parkinson disease is a prerequisite for preventive therapeutic approaches. Modified serpinA1 in cerebrospinal fluid (CSF) was suggested as an early biomarker for differentiation between Parkinson patients with (PDD) or without dementia (PD).
Halbgebauer, Steffen +12 more
openaire +5 more sources
Proteomics for rejection diagnosis in renal transplant patients: where are we now? [PDF]
, 2016 Rejection is one of the key factors that determine the long-term allograft function and survival in renal transplant patients. Reliable and timely diagnosis is important to treat rejection as early as possible.
Gwinner, Wilfried +3 more
core +1 more source
Distinct Roles of IL‐4, IL‐13, and IL‐22 in Human Skin Barrier Dysfunction and Atopic Dermatitis
Allergy, Volume 81, Issue 2, Page 480-497, February 2026.This study reports the distinct effects of IL‐4, IL‐13, and IL‐22 on bio‐stabilized human skin with intact barriers and immune cells. IL‐4, IL‐13, and IL‐22 upregulate inflammatory mediators, disrupt skin barrier integrity, and reciprocally modulate IL‐4Rα and IL‐22Rα1 receptors.
Paolo D'Avino +12 more
wiley +1 more source
Proteomic analysis of heart failure hospitalization among patients with chronic kidney disease: The Heart and Soul Study. [PDF]
, 2018 BACKGROUND:Patients with chronic kidney disease (CKD) are at increased risk for heart failure (HF). We aimed to investigate differences in proteins associated with HF hospitalizations among patients with and without CKD in the Heart and Soul Study ...
Dubin, Ruth F +5 more
core +2 more sources
Andrology, Volume 14, Issue 2, Page 555-570, February 2026.Abstract Background Predicting male fertility in farm animals remains a challenge. Seminal plasma (SP) contains a high amount of heterogeneous seminal extracellular vesicles (sEVs), believed involved in reproductive processes and maybe key to understanding male fertility.
Isabel Barranco +6 more
wiley +1 more source
SERPINA2 Is a Novel Gene with a Divergent Function from SERPINA1
PLoS ONE, 2013 Serine protease inhibitors (SERPINs) are a superfamily of highly conserved proteins that play a key role in controlling the activity of proteases in diverse biological processes. The SERPIN cluster located at the 14q32.1 region includes the gene coding for SERPINA1, and a highly homologous sequence, SERPINA2, which was originally thought to be a ...
Marques, Patrícia Isabel +8 more
openaire +5 more sources
Non melanoma skin cancer pathogenesis overview [PDF]
, 2018 (1)Background: Non-melanoma skin cancer is the most frequently diagnosed cancer in humans. The process of skin carcinogenesis is still not fully understood.
Bottoni Ugo +3 more
core +1 more source
Cancer Science, Volume 117, Issue 2, Page 566-575, February 2026.Malignant ovarian germ cell tumor subtypes exhibit distinct tumor microenvironments. Dysgerminomas harbor abundant nonexhausted T cells, with progenitor exhausted T cells present in 60% of PD‐1–positive cases. However, MHC class I expression is lost across all analyzed subtypes, suggesting that restoring class I expression in dysgerminomas may enhance ...
Miya Nakashima +13 more
wiley +1 more source
PLoS ONE, 2023 Alpha-1 antitrypsin deficiency (AATD), a relatively common autosomal recessive genetic disorder, is underdiagnosed in symptomatic individuals. We sought to compare the risk of liver transplantation associated with hepatitis C infection with AATD ...
Bryce A. Schuler +5 more
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