Results 101 to 110 of about 10,821 (196)
SERPINA2 Is a Novel Gene with a Divergent Function from SERPINA1
PLoS ONE, 2013 Serine protease inhibitors (SERPINs) are a superfamily of highly conserved proteins that play a key role in controlling the activity of proteases in diverse biological processes. The SERPIN cluster located at the 14q32.1 region includes the gene coding for SERPINA1, and a highly homologous sequence, SERPINA2, which was originally thought to be a ...
Marques, Patrícia Isabel +8 more
openaire +5 more sources
Proteomic analysis of heart failure hospitalization among patients with chronic kidney disease: The Heart and Soul Study. [PDF]
, 2018 BACKGROUND:Patients with chronic kidney disease (CKD) are at increased risk for heart failure (HF). We aimed to investigate differences in proteins associated with HF hospitalizations among patients with and without CKD in the Heart and Soul Study ...
Dubin, Ruth F +5 more
core +2 more sources
FASEB BioAdvances, Volume 8, Issue 3, March 2026.We enrolled a pediatric sepsis cohort at acute and recovery phases for plasma proteomics analysis. Abundantly expressed proteins in sepsis were identified and subjected to machine learning. In addition, the data was compared to adult sepsis and sterile inflammation.
Fahd Alhamdan +7 more
wiley +1 more source
Identification of Novel Short C-Terminal Transcripts of Human SERPINA1 Gene
PLOS ONE, 2017 Human SERPINA1 gene is located on chromosome 14q31-32.3 and is organized into three (IA, IB, and IC) non-coding and four (II, III, IV, V) coding exons. This gene produces α1-antitrypsin (A1AT), a prototypical member of the serpin superfamily of proteins.
Nerea Matamala +10 more
openaire +8 more sources
, 2014 Why only 20% of smokers develop clinically relevant chronic obstructive pulmonary disease (COPD) was a puzzle for many years. Now, epidemiologic studies point clearly toward a large heritable component.
Lomas, David A, Marciniak, Stefan J
core +1 more source
Advanced Science, Volume 13, Issue 9, 13 February 2026.This study identifies Membralin as an ER‐phagy receptor that recruits MAN1B1 and VCP to form a selective ERLAD complex. By sensing dense N‐glycan clusters on viral fusion glycoproteins, this ubiquitin‐independent pathway directs SARS‐CoV‐2 spike, Ebola GP, influenza HA, and HIV‐1 Env to lysosomal degradation, thereby limiting viral infectivity ...
Jing Zhang +5 more
wiley +1 more source
Network analysis of quantitative proteomics on asthmatic bronchi: effects of inhaled glucocorticoid treatment [PDF]
, 2011 Background Proteomic studies of respiratory disorders have the potential to identify protein biomarkers for diagnosis and disease monitoring. Utilisation of sensitive quantitative proteomic methods creates opportunities to determine individual patient ...
Serena E O'Neil +9 more
core +1 more source
Genetic variants underlying precancerous conditions of hepatocellular carcinoma
International Journal of Cancer, Volume 158, Issue 3, Page 488-502, 1 February 2026.Abstract Hepatocellular carcinoma (HCC) is the most common form of liver cancer, accounting for 80% of cases worldwide. While chronic hepatitis B and C infections remain primary risk factors, emerging evidence highlights the increasing contributions of metabolic dysfunction‐associated steatotic liver disease (MASLD) and alcohol‐associated liver disease
Jonathan Jaime G. Guerrero +7 more
wiley +1 more source
PLoS ONE, 2023 Alpha-1 antitrypsin deficiency (AATD), a relatively common autosomal recessive genetic disorder, is underdiagnosed in symptomatic individuals. We sought to compare the risk of liver transplantation associated with hepatitis C infection with AATD ...
Bryce A. Schuler +5 more
doaj
Molecular Targets of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) within the Zebrafish Ovary: Insights into TCDD-induced Endocrine Disruption and Reproductive Toxicity [PDF]
, 2008 TCDD is a reproductive toxicant and endocrine disruptor, yet the mechanisms by which it causes these reproductive alterations are not fully understood.
Carvan, Michael J., III +5 more
core +1 more source