Results 111 to 120 of about 11,907 (228)
, 2014 Why only 20% of smokers develop clinically relevant chronic obstructive pulmonary disease (COPD) was a puzzle for many years. Now, epidemiologic studies point clearly toward a large heritable component.
Lomas, David A, Marciniak, Stefan J
core +1 more source
Advanced Science, Volume 13, Issue 4, 19 January 2026.This study provides a multi‐omics landscape of treatment‐naïve colorectal liver metastasis and reveals dysregulated molecules and cellular pathways. SHMT1 and NDRG1 Ser330 phosphorylation are demonstrated to display crucial roles in tumorigenesis and liver metastasis. Two proteomics subtypes (metabolism and RNA function) with distinct clinical outcomes
Wensi Zhao +20 more
wiley +1 more source
Molecular Targets of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) within the Zebrafish Ovary: Insights into TCDD-induced Endocrine Disruption and Reproductive Toxicity [PDF]
, 2008 TCDD is a reproductive toxicant and endocrine disruptor, yet the mechanisms by which it causes these reproductive alterations are not fully understood.
Carvan, Michael J., III +5 more
core +1 more source
An antibody raised against a pathogenic serpin variant induces mutant-like behaviour in the wild-type protein. [PDF]
, 2015 A monoclonal antibody (mAb) that binds to a transient intermediate may act as a catalyst for the corresponding reaction; here we show this principle can extend on a macro-molecular scale to the induction of mutant-like oligomerisation in a wild-type ...
Faull, SV +7 more
core +1 more source
Migrasomes in Ischemic Stroke: Molecular Landscape and Pathophysiological Impact
Advanced Science, Volume 13, Issue 6, 30 January 2026.Multi‐omics profiling of stroke patients exposes systemic molecular fingerprints of immune activation, oxidative stress and metabolic collapse. Complement and coagulation cascade, and cholesterol metabolism emerge as shared functional hallmarks of plasma migrasomes in stroke patients and migrasomes isolated from experimental stroke mice.
Huifen Zhou +16 more
wiley +1 more source
Postural Changes in Blood Pressure Associated with Interactions between Candidate Genes for Chronic Respiratory Diseases and Exposure to Particulate Matter [PDF]
, 2009 BACKGROUND. Fine particulate matter [aerodynamic diameter ≤ 2.5 μm (PM2.5)] has been associated with autonomic dysregulation. OBJECTIVE. We hypothesized that PM2.5 influences postural changes in systolic blood pressure (ΔSBP) and in diastolic blood ...
Andrea Baccarelli +13 more
core +3 more sources
Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.Abstract INTRODUCTION Alzheimer's disease (AD) study participants may present with cognitive impairment who do not have brain amyloid deposits (Aβ−). Identifying predictive biomarkers for non‐amyloid‐related CI may provide better screening tests for trials seeking only CI Aβ+ participants and new therapy targets.
Richard C. Mohs +11 more
wiley +1 more source
The pathological Trento variant of alpha-1-antitrypsin (E75V) shows non-classical behaviour during polymerization [PDF]
, 2017 Severe alpha-1-antitrypsin deficiency (AATD) is most frequently associated with the alpha-1-antitrypsin (AAT) Z variant (E342K). ZZ homozygotes exhibit accumulation of AAT as polymers in the endoplasmic reticulum of hepatocytes.
Bodker +50 more
core +2 more sources
Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.Abstract INTRODUCTION Proteins interacting with amyloid beta (Aβ) fibrils could be key to plaque formation in Alzheimer's disease (AD) and represent potential biomarkers and therapeutic targets. Previous proteomic studies using microdissected plaques might have captured non‐specific components rather than true Aβ interactors.
Ana Montero‐Calle +10 more
wiley +1 more source
Associations between SNPs and immune-related circulating proteins in schizophrenia [PDF]
, 2017 Genome-wide association studies (GWAS) and proteomic studies have provided convincing evidence implicating alterations in immune/inflammatory processes in schizophrenia.
Bahn, S +8 more
core +2 more sources