Results 41 to 50 of about 14,423 (252)
Immunology, 2020 Serpins are evolutionarily conserved serine protease inhibitors that are widely distributed in animals, plants and microbes. In this study, we reported the cloning and functional characterizations of two novel serpin genes, HlSerpin‐a and HlSerpin‐b ...
F. Wang +6 more
semanticscholar +1 more source
Agriculture, 2022 RNA interference (RNAi) induces gene silencing in order to participate in immune-related pathways. Previous studies have shown that the LmSerpin1 gene upregulates the immune responses of Locusta migratoria manilensis, and that the infection of locusts ...
Junya Wang +7 more
doaj +1 more source
Serpins, New Therapeutic Targets for Hemophilia
Thrombosis and Haemostasis, 2020 Hemostasis is a tightly regulated process characterized by a finely tuned balance between procoagulant and anticoagulant systems. Among inherited hemostatic conditions, hemophilia is one of the most well-known bleeding disorders. Hemophilia A (HA) and B (
Karen Aymonnier +4 more
semanticscholar +1 more source
Arginine Inhibits Serpins [PDF]
Clinical and Applied Thrombosis/Hemostasis, 2007 Serine protease inactivators (serpins) are important regulators in biochemistry. Often it is necessary to block the serpin action, that is, to stabilize the sample. The guanidine group of arginine is the ligand for the active center pocket of many serine proteases.
openaire +3 more sources
Control of granzymes by serpins [PDF]
Cell Death & Differentiation, 2010 Although proteolysis mediated by granzymes has an important role in the immune response to infection or tumours, unrestrained granzyme activity may damage normal cells. In this review, we discuss the role of serpins within the immune system, as specific regulators of granzymes. The well-characterised human granzyme B-SERPINB9 interaction highlights the
D. Kaiserman, P. Bird
semanticscholar +4 more sources
PLoS ONE, 2021 Here, we studied the expression pattern and putative function of four, previously identified serine protease inhibitors (serpins) of Myxobolus cerebralis, a pathogenic myxozoan species (Cnidaria: Myxozoa) causing whirling disease of salmonid fishes.
Edit Eszterbauer +4 more
doaj +1 more source
Annals of Medicine, 2023 Objective To explore potential biomarkers indicating endometriosis (EM).Materials and methods A proteomics method and combined quantitative transcriptomics were adopted to highlight markers in the EM.
Xiao-yan Li +5 more
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An overview of the serpin superfamily.
Genome biology, 2006 Serpins are a broadly distributed family of protease inhibitors that use a conformational change to inhibit target enzymes. They are central in controlling many important proteolytic cascades, including the mammalian coagulation pathways. Serpins are conformationally labile and many of the disease-linked mutations of serpins result in misfolding or in ...
James C. Whisstock +11 more
openaire +3 more sources
BMC Genomics, 2009 Background The Drosophila melanogaster genome contains 29 serpin genes, 12 as single transcripts and 17 within 6 gene clusters. Many of these serpins have a conserved "hinge" motif characteristic of active proteinase inhibitors.
Micklem Gos +4 more
doaj +1 more source
Identification and in-silico characterization of Serpin genes in legumes genomes
The Indian Journal of Agricultural Sciences, 2020 Serine protease inhibitors (serpins) are a unique family of protease inhibitor containing mobile reactive center loop. The availability of genome sequences of pigeonpea, soybean, commanbean, cowpea, mungbean and adzuki bean provided an opportunity to ...
PAWAN S MAINKAR +5 more
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