Results 61 to 70 of about 20,002 (295)

Heparin Blocks the Inhibition of Tissue Kallikrein 1 by Kallistatin through Electrostatic Repulsion

Biomolecules, 2020
Kallistatin, also known as SERPINA4, has been implicated in the regulation of blood pressure and angiogenesis, due to its specific inhibition of tissue kallikrein 1 (KLK1) and/or by its heparin binding ability.
Lina Ma, Jiawei Wu, Ying Zheng, Zimei Shu, Zhenquan Wei, Yinbiao Sun, Robin W. Carrell, Aiwu Zhou   +7 more
doaj   +1 more source

An overview of the serpin superfamily.

Genome biology, 2006
Serpins are a broadly distributed family of protease inhibitors that use a conformational change to inhibit target enzymes. They are central in controlling many important proteolytic cascades, including the mammalian coagulation pathways. Serpins are conformationally labile and many of the disease-linked mutations of serpins result in misfolding or in ...
James C. Whisstock, James C. Whisstock, Qingwei Zhang, Sheena McGowan, Robert N. Pike, Gary A. Silverman, Christopher G. Langendorf, Phillip I. Bird, Wilson Wong, Ruby H. P. Law, Carlos J. Rosado, Ashley M. Buckle   +11 more
openaire   +3 more sources

Smoothing a rugged protein folding landscape by sequence-based redesign [PDF]

, 2016
The rugged folding landscapes of functional proteins puts them at risk of misfolding and aggregation. Serine protease inhibitors, or serpins, are paradigms for this delicate balance between function and misfolding.
Borg, NA, Bottomley, SP, Buckle, AM, Costa, MGS, Dai, W, Hoke, DE, Hollins, JJ, Irving, JA, Kass, I, Keleher, S, Marijanovic, EM, McGowan, S, Nickson, AA, Pearce, MA, Porebski, BT, Webb, GI, Whisstock, JC, Zhu, L   +17 more
core   +4 more sources

Feeding dsSerpin1 Enhanced Metarhizium anisopliae Insecticidal Efficiency against Locusta migratoria manilensis

Agriculture, 2022
RNA interference (RNAi) induces gene silencing in order to participate in immune-related pathways. Previous studies have shown that the LmSerpin1 gene upregulates the immune responses of Locusta migratoria manilensis, and that the infection of locusts ...
Junya Wang, Hongmei Li, Yumeng Cheng, Guangjun Wang, Xiangqun Nong, Belinda Luke, Undarmaa Davaasambuu, Guocai Zhang   +7 more
doaj   +1 more source

A genomic analysis and transcriptomic atlas of gene expression in Psoroptes ovis reveals feeding- and stage-specific patterns of allergen expression [PDF]

, 2019
Background: Psoroptic mange, caused by infestation with the ectoparasitic mite, Psoroptes ovis, is highly contagious, resulting in intense pruritus and represents a major welfare and economic concern for the livestock industry Worldwide.
Bartley, Kathryn, Burgess, Stewart TG, Down, Rachel E, Dunn, Jackie, Marr, Edward J, Nisbet, Alasdair J, Nunn, Francesca G, Prickett, Jessica C, Rombauts, Stephane, Van de Peer, Yves, Van Leeuwen, Thomas, Weaver, Robert J   +11 more
core   +2 more sources

Mechanistic behaviour and molecular interactions of heat shock protein 47 (HSP47) [PDF]

, 2012
This project involves the study of heat shock protein 47 (HSP47), which is a molecular chaperone crucial for collagen biosynthesis. It exhibits a high degree of sequence homology with members of the serine protease inhibitor (serpin) superfamily, though ...
Abdul Wahab, Mohd Firdaus, Abdul Wahab, Mohd Firdaus   +1 more
core   +1 more source

Identification and in-silico characterization of Serpin genes in legumes genomes

The Indian Journal of Agricultural Sciences, 2020
Serine protease inhibitors (serpins) are a unique family of protease inhibitor containing mobile reactive center loop. The availability of genome sequences of pigeonpea, soybean, commanbean, cowpea, mungbean and adzuki bean provided an opportunity to ...
PAWAN S MAINKAR, MANOJ M L, DEEPANSHU JAYASWAL, YAMINI AGARWAL, RAKESH K PRAJAPAT, REKHA KANSAL   +5 more
doaj   +1 more source

Proteomic analysis of the excretory-secretory products from larval stages of Ascaris suum reveals high abundance of glycosyl hydrolases [PDF]

, 2013
Background: Ascaris lumbricoides and Ascaris suum are socioeconomically important and widespread parasites of humans and pigs, respectively. The excretory-secretory (ES) molecules produced and presented at the parasite-host interface during the different
Deforce, Dieter, Dhaenens, Maarten, Gasser, Robin B, Geldhof, Peter, Jex, Aaron R, Van Steendam, Katleen, Vlaminck, Johnny, Wang, Tao   +7 more
core   +5 more sources

Structural aspects of serpin inhibition [PDF]

FEBS Letters, 1994
The essential roles of proteins of the serpin family in many physiological processes, along with new discoveries of their unique folding properties, have attracted intense interest in recent years. Many serpins display unusual mobile behavior attributed to rearrangements of α‐helical or β‐sheet domains, whereby large scale transitions accompany a ...
Andreas Schulze, Richard A. Engh, Robert Huber, Wolfram Bode   +3 more
openaire   +3 more sources

Escaping Antiangiogenic Therapy: Strategies Employed by Cancer Cells [PDF]

, 2016
Indexación: Web of ScienceTumor angiogenesis is widely recognized as one of the hallmarks of cancer. Consequently, during the last decades the development and testing of commercial angiogenic inhibitors has been a central focus for both basic and ...
Carrasco-Avino, G, Corvalan, AH, Owen, GI, Pinto, MP, Sotomayor, P   +4 more
core   +1 more source