Results 61 to 70 of about 20,613 (283)
Smoothing a rugged protein folding landscape by sequence-based redesign [PDF]
, 2016 The rugged folding landscapes of functional proteins puts them at risk of misfolding and aggregation. Serine protease inhibitors, or serpins, are paradigms for this delicate balance between function and misfolding.
Borg, NA +17 more
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Arginine Inhibits Serpins [PDF]
Clinical and Applied Thrombosis/Hemostasis, 2007 Serine protease inactivators (serpins) are important regulators in biochemistry. Often it is necessary to block the serpin action, that is, to stabilize the sample. The guanidine group of arginine is the ligand for the active center pocket of many serine proteases.
openaire +2 more sources
Serpins, New Therapeutic Targets for Hemophilia
Thrombosis and Haemostasis, 2020 Hemostasis is a tightly regulated process characterized by a finely tuned balance between procoagulant and anticoagulant systems. Among inherited hemostatic conditions, hemophilia is one of the most well-known bleeding disorders. Hemophilia A (HA) and B (
Karen Aymonnier +4 more
semanticscholar +1 more source
PLoS ONE, 2021 Here, we studied the expression pattern and putative function of four, previously identified serine protease inhibitors (serpins) of Myxobolus cerebralis, a pathogenic myxozoan species (Cnidaria: Myxozoa) causing whirling disease of salmonid fishes.
Edit Eszterbauer +4 more
doaj +1 more source
Inhibitory serpins. New insights into their folding, polymerization, regulation and clearance
Biochemical Journal, 2016 Peter G.W. Gettins, Steven T. Olson
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A genomic analysis and transcriptomic atlas of gene expression in Psoroptes ovis reveals feeding- and stage-specific patterns of allergen expression [PDF]
, 2019 Background: Psoroptic mange, caused by infestation with the ectoparasitic mite, Psoroptes ovis, is highly contagious, resulting in intense pruritus and represents a major welfare and economic concern for the livestock industry Worldwide.
Bartley, Kathryn +11 more
core +2 more sources
Nature, 1994 Recent structures of members of the serine proteinase inhibitor families (serpins) continue to emphasize the flexibility of the reactive loop and suggest possible 'active' conformations.
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Serpins: the uncut version [PDF]
Structure, 1994 The structure of active antithrombin, the first active serpin to be solved, sheds new light on the conformational forms of this important class of inhibitor.
E J, Goldsmith, J, Mottonen
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Proteomic analysis of the excretory-secretory products from larval stages of Ascaris suum reveals high abundance of glycosyl hydrolases [PDF]
, 2013 Background: Ascaris lumbricoides and Ascaris suum are socioeconomically important and widespread parasites of humans and pigs, respectively. The excretory-secretory (ES) molecules produced and presented at the parasite-host interface during the different
Deforce, Dieter +7 more
core +5 more sources
Agriculture, 2022 RNA interference (RNAi) induces gene silencing in order to participate in immune-related pathways. Previous studies have shown that the LmSerpin1 gene upregulates the immune responses of Locusta migratoria manilensis, and that the infection of locusts ...
Junya Wang +7 more
doaj +1 more source