Results 111 to 120 of about 72,366 (294)

MCL‐1 inhibition triggers a largely reversible cardiac stress signature in a humanised mouse model

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Myeloid cell leukaemia‐1 (MCL‐1) is an essential anti‐apoptotic protein and a promising therapeutic target in oncology. Early clinical studies of MCL‐1 inhibitors reported unexpected elevations in cardiac troponin, raising concerns about potential cardiotoxicity.
Markus B. Heckmann, Zsanett Papdi, Nils J. Strauch, Daniel Finke, Marc‐Steffen Raab, Antje Blank, Norbert Frey, Lorenz H. Lehmann   +7 more
wiley   +1 more source

Rifaximin ameliorates memory impairment and Alzheimer's pathological changes in APP/PS1 mice associated with changes in the gut microbiome–bile acids–serum metabolites networks

British Journal of Pharmacology, EarlyView.
Background and Purpose Modifying the brain–gut–microbiota axis has emerged as a promising therapeutic strategy against Alzheimer's disease (AD). Whether rifaximin, a non‐absorbed and non‐systemic antibiotic, can be applied to the treatment of AD remains unexplored.
Di Wu, Mei‐Tong Nie, Jixian Lin, Yang Liu, Yong Wang, Min Chu, Lan Zheng, Jing Zhao   +7 more
wiley   +1 more source

Cionus wittei Kirsch 1881

, 2007
Cionus wittei Kirsch 1881 Material: 3 specimens examined: 26.06. 1989, Saricakaya­Eskisehir (Turkey), O. SERT. Genital spicule oval shape at posterior, slightly expanded from proximal to apical; arms of eighth sternite jointed at apex resemble to ...
Sert, Osman
core   +1 more source

The c‐Src inhibitor eCF506 diminishes opioid tolerance and reduces β‐arrestin2 recruitment

British Journal of Pharmacology, EarlyView.
Morphine activation of μ receptors causes tolerance through c‐Src activation and β‐arrestin2 recruitment. c‐Src inhibition or degradation reduces β‐arrestin2 recruitment, μ receptor endocytosis, while causing receptor upregulation, all likely contributing to reduced morphine tolerance.
Samuel Singleton, Fraser Nunn, Erika Lace, Álvaro Lorente‐Macías, Rachel Toth, Asier Unciti‐Broceta, Tim G. Hales   +6 more
wiley   +1 more source

Selective excitatory effects of γ‐glutamyl‐glycine, a glutathione metabolite, on GluN1 NMDA and mGlu5 receptors impacting synaptic plasticity

British Journal of Pharmacology, EarlyView.
Background and Purpose Gamma‐glutamyl dipeptides are essentially produced after glutathione (GSH) degradation. While several γ‐glutamyl dipeptides have been detected in different organs and body fluids, their biological activity remains elusive. This is the case for γ‐Glutamyl‐Glycine (γ‐Glu‐Gly) which has been found in different brain areas.
Sandro Andreu, Victoria Gizzi, Ugo Pasco, Fatiha Sebih, Yattou Zitouni, Pablo Jimenez, Valérie Rolland, Alain Chavanieu, Sébastien Estaran, Matthieu Rousset, Thierry Cens, Guillaume Cazals, Pierre Charnet, Janique Guiramand, Catherine Cohen‐Solal, Claudine Ménard, Marie‐Céleste de Jésus Ferreira, Nathalie Chevallier, Sonia Cantel, Michel Vignes, Julien Roussel   +20 more
wiley   +1 more source

Sert y Giedion.

DC Papers. Revista de crítica i teoria de l'arquitectura, 2005
Peer ...
openaire   +3 more sources

Sert maden uçlar

, 1984
62
openaire   +2 more sources

Inhibition of the NR4A1‐mediated cell cycle checkpoint enhances hyperplastic adipogenesis and glucose homeostasis in obesity

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose The nuclear receptor NR4A1 is a critical node in transcriptional circuits for metabolic adaptation, yet its role in adipocyte progenitor (AP) fate and proliferation is unclear. We sought to define how NR4A1 governs early adipogenesis and adipose tissue plasticity.
Wanning Qiao, Cun Ku, G. V. Naveen Kumar, Jonathan D. Brown, Manni Wu, Chenhang Li, Jiyu Xie, Huicui Meng, Litao Sun, Tao Zhou, Dong Liang, Yiwei Li, Matthew L. Steinhauser, Yang Zhang   +13 more
wiley   +1 more source

Sert, propuesto doctor “honoris causa”

, 1980
Universitat Politècnica. Sert, propuesto doctor “honoris causa”.

core  

Gene Sert e risposta agli SSRI: è clinicamente utile?

Il gene del trasportatore della serotonina (SERT, 5-HTT, SLC6A4) può influenzare la risposta agli SSRI e gli effetti collaterali, in particolare negli uomini caucasici più anziani.
Mercedes Guaia Memita Guaia
core   +1 more source