E4 Transcription Factor 1 (E4F1) Regulates Sertoli Cell Proliferation and Fertility in Mice [PDF]
Animals, 2020 In the mammalian testes, Sertoli cells are the only somatic cells in the seminiferous tubules that provide structural, nutritional and regulatory support for developing spermatogenic cells.
Rong-Ge Yan, Qi-Lin Yang, Qi-En Yang
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Sertoli Cells Enhance Formation of Capillary-Like Structures in Vitro
Cell Transplantation, 2008 Sertoli cells isolated from the testis (referred to as extratesticular Sertoli cells) have been shown to facilitate allo- and xenogeneic cell transplantations.
Brian T. Golat, Don F. Cameron Ph.D.
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The impact of Connexin 43 deficiency on the cell shape and cytoskeleton of murine Sertoli cells: A house with ramshackle walls? [PDF]
PLoS ONEGenetically induced loss of the gap-junction protein Connexin 43 (Cx43) in murine Sertoli cells leads to an arrest of spermatogenesis at the level of spermatogonia, highly vacuolated tubules, and intratubular cell clusters.
Mareike Ueffing +11 more
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RAD21L1 Is Sufficient and Effective for Reprogramming Human Sertoli Cells to Phenotypic Spermatogonial Stem Cells Through DNA Methylation and Essential for Male Fertility [PDF]
Advanced ScienceIt remains unknown about molecular mechanisms underlying the transition of somatic cells into male germ cells. It is observed that RAD21L1 transcript is upregulated during reprogramming of Sertoli cells into human spermatogonial stem cells (SSCs) by ...
Caimei He +4 more
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Molecular Mechanisms and Signaling Pathways Involved in Sertoli Cell Proliferation
Frontiers in Endocrinology, 2019 Sertoli cells are somatic cells present in seminiferous tubules which have essential roles in regulating spermatogenesis. Considering that each Sertoli cell is able to support a limited number of germ cells, the final number of Sertoli cells reached ...
Meroni Sb +2 more
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Sertoli cell only syndrome: Status of sertoli cell maturation and function
Indian Journal of Endocrinology and Metabolism, 2012 Background of the study: Mature and functional Sertoli cells are essential for the survival of germ cells in testes. In Sertoli cell only syndrome (SCOS), there is no germ cells.
Manish Jain, Ashutosh Halder
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Comparative RNA-Seq analysis of differentially expressed genes in the sertoli cells of yak and cattle-yak [PDF]
BMC Veterinary ResearchBackground To study the problem of male sterility of cattle-yak and improve the yak crossbreeding, this study obtained the testicular Sertoli cells of yak and cattle-yak and compared the differences in transcriptome levels between the two bovine species.
Xue-Mei Chen +9 more
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Unveiling the roles of Sertoli cells lineage differentiation in reproductive development and disorders: a review [PDF]
Frontiers in EndocrinologyIn mammals, gonadal somatic cell lineage differentiation determines the development of the bipotential gonad into either the ovary or testis. Sertoli cells, the only somatic cells in the spermatogenic tubules, support spermatogenesis during gonadal ...
Yang Gao +12 more
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Long-term effects of early postnatal stress on Sertoli cells
Frontiers in Genetics, 2022 Sertoli cells are somatic cells in testis essential for spermatogenesis, that support the development, maturation, and differentiation of germ cells.
Kristina M. Thumfart +5 more
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Frontiers in Endocrinology, 2022 Androgen receptor signaling pathway is necessary to complete spermatogenesis in testes. Difference between androgen binding location in Sertoli cell classifies androgen receptor signaling pathway into classical signaling pathway and non-classical ...
Jia-Ming Wang, Zhen-Fang Li, Wan-Xi Yang
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