Results 1 to 10 of about 32,723 (247)

E4 Transcription Factor 1 (E4F1) Regulates Sertoli Cell Proliferation and Fertility in Mice [PDF]

Animals, 2020
In the mammalian testes, Sertoli cells are the only somatic cells in the seminiferous tubules that provide structural, nutritional and regulatory support for developing spermatogenic cells.
Rong-Ge Yan, Qi-Lin Yang, Qi-En Yang
doaj   +2 more sources

Sertoli Cells Enhance Formation of Capillary-Like Structures in Vitro

Cell Transplantation, 2008
Sertoli cells isolated from the testis (referred to as extratesticular Sertoli cells) have been shown to facilitate allo- and xenogeneic cell transplantations.
Brian T. Golat, Don F. Cameron Ph.D.
doaj   +2 more sources

The impact of Connexin 43 deficiency on the cell shape and cytoskeleton of murine Sertoli cells: A house with ramshackle walls? [PDF]

PLoS ONE
Genetically induced loss of the gap-junction protein Connexin 43 (Cx43) in murine Sertoli cells leads to an arrest of spermatogenesis at the level of spermatogonia, highly vacuolated tubules, and intratubular cell clusters.
Mareike Ueffing, Marion Langeheine, Sarah Gniesmer, Kristina Rode, Sarah Staggenborg, Gudrun Wirth, Kerstin Rohn, Rüdiger Koch, Ines Blume, Christiane Pfarrer, Christoph Wrede, Ralph Brehm   +11 more
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RAD21L1 Is Sufficient and Effective for Reprogramming Human Sertoli Cells to Phenotypic Spermatogonial Stem Cells Through DNA Methylation and Essential for Male Fertility [PDF]

Advanced Science
It remains unknown about molecular mechanisms underlying the transition of somatic cells into male germ cells. It is observed that RAD21L1 transcript is upregulated during reprogramming of Sertoli cells into human spermatogonial stem cells (SSCs) by ...
Caimei He, Yinghong Cui, Wei Chen, Chunyun Li, Zuping He   +4 more
doaj   +2 more sources

Sertoli cell only syndrome: Status of sertoli cell maturation and function

Indian Journal of Endocrinology and Metabolism, 2012
Background of the study: Mature and functional Sertoli cells are essential for the survival of germ cells in testes. In Sertoli cell only syndrome (SCOS), there is no germ cells.
Manish Jain, Ashutosh Halder
doaj   +3 more sources

Comparative RNA-Seq analysis of differentially expressed genes in the sertoli cells of yak and cattle-yak [PDF]

BMC Veterinary Research
Background To study the problem of male sterility of cattle-yak and improve the yak crossbreeding, this study obtained the testicular Sertoli cells of yak and cattle-yak and compared the differences in transcriptome levels between the two bovine species.
Xue-Mei Chen, Ming-Xiu Wang, Peng Zhang, Ke-Min Jing, Bing-Lin Yue, Zhi-Juan Wu, Zhi-Xin Chai, Xin-Rui Liu, Jin-Cheng Zhong, Xin Cai   +9 more
doaj   +2 more sources

Long-term effects of early postnatal stress on Sertoli cells

Frontiers in Genetics, 2022
Sertoli cells are somatic cells in testis essential for spermatogenesis, that support the development, maturation, and differentiation of germ cells.
Kristina M. Thumfart, Samuel Lazzeri, Samuel Lazzeri, Samuel Lazzeri, Francesca Manuella, Isabelle M. Mansuy   +5 more
doaj   +1 more source

What Does Androgen Receptor Signaling Pathway in Sertoli Cells During Normal Spermatogenesis Tell Us?

Frontiers in Endocrinology, 2022
Androgen receptor signaling pathway is necessary to complete spermatogenesis in testes. Difference between androgen binding location in Sertoli cell classifies androgen receptor signaling pathway into classical signaling pathway and non-classical ...
Jia-Ming Wang, Zhen-Fang Li, Wan-Xi Yang
doaj   +1 more source

Updates in Sertoli Cell-Mediated Signaling During Spermatogenesis and Advances in Restoring Sertoli Cell Function

Frontiers in Endocrinology, 2022
Since their initial description by Enrico Sertoli in 1865, Sertoli cells have continued to enchant testis biologists. Testis size and germ cell carrying capacity are intimately tied to Sertoli cell number and function.
Victor A. Ruthig, Victor A. Ruthig, Dolores J. Lamb, Dolores J. Lamb   +3 more
doaj   +1 more source

Hsa-miR-100-3p Controls the Proliferation, DNA Synthesis, and Apoptosis of Human Sertoli Cells by Binding to SGK3

Frontiers in Cell and Developmental Biology, 2021
Human Sertoli cell is required for completing normal spermatogenesis, and significantly, it has important applications in reproduction and regenerative medicine because of its great plasticity.
Bang Liu, Yinghong Cui, Wei Chen, Li Du, Chunyun Li, Cailin Wan, Zuping He   +6 more
doaj   +1 more source