Results 81 to 90 of about 2,828,019 (403)

Electrostatics in the Stability and Misfolding of the Prion Protein: Salt Bridges, Self-Energy, and Solvation [PDF]

Biochemistry and Cell Biology 2010, Volume 88, Number 2, Pages 371 - 381, 2010
Using a recently developed mesoscopic theory of protein dielectrics, we have calculated the salt bridge energies, total residue electrostatic potential energies, and transfer energies into a low dielectric amyloid-like phase for 12 species and mutants of the prion protein.
arxiv   +1 more source

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

Serum amyloid P aids complement-mediated immunity to Streptococcus pneumoniae [PDF]

, 2007
The physiological functions of the acute phase protein serum amyloid P (SAP) component are not well defined, although they are likely to be important, as no natural state of SAP deficiency has been reported.
Botto, M., Bottoms, S.E., Brown, J.S., Yuste, J.   +3 more
core  

Dysregulation of Na+/K+ ATPase by amyloid in APP+PS1 transgenic mice [PDF]

, 2005
BACKGROUND: The pathology of Alzheimer's disease (AD) is comprised of extracellular amyloid plaques, intracellular tau tangles, dystrophic neurites and neurodegeneration. The mechanisms by which these various pathological features arise are under intense
Dickey, Chad A, Freeman, Melissa J, Gordon, Marcia N, Herber, Donna L, Morgan, Dave, Wilcock, Donna M   +5 more
core   +3 more sources

“Therapies Through Gut:” Targeted Drug Delivery for Non‐Gastrointestinal Diseases by Oral Administration

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the mechanism of targeted delivery of nanoparticles including 1) paracellular, 2) endolysosomal escape, 3) receptor mediated endocytosis, and 4) M cell mediated transport for non‐GI diseases by oral administration such as atherosclerosis, cancer, diabetes, and brain diseases. Abstract Oral drug delivery is a promising approach
Subarna Ray, Shehzahdi S. Moonshi, Hang Thu Ta   +2 more
wiley   +1 more source

Herpes simplex virus interferes with amyloid precursor protein processing [PDF]

, 2005
Background The early events underlying Alzheimer's disease (AD) remain uncertain, although environmental factors may be involved. Work in this laboratory has shown that the combination of herpes simplex virus type 1 (HSV1) in brain and carriage of the
Dobson, C.B., Itzhaki, R.F., Parkin, E.T., Shipley, S.J.   +3 more
core   +4 more sources

Successful treatment of AA amyloidosis with tocilizumab, resulting in the disappearance of amyloid deposits: a case-based review

Egyptian Rheumatology and Rehabilitation
Background AA amyloidosis is a multisystem disease characterized by the deposition of serum amyloid A protein, which is secondary to chronic inflammation.
Marina Tortosa-Cabañas, José Acosta Batlle, Cristian Perna, Javier Bachiller-Corral   +3 more
doaj   +1 more source

Self-assembly of protein amyloid: a competition between amorphous and ordered aggregation [PDF]

Physical Review E 80, 031922 (2009), 2008
Protein aggregation in the form of amyloid fibrils has important biological and technological implications. Although the self-assembly process is highly efficient, aggregates not in the fibrillar form would also occur and it is important to include these disordered species when discussing the thermodynamic equilibrium behavior of the system.
arxiv   +1 more source

Systematic Comparison of Commercial Uranyl‐Alternative Stains for Negative‐ and Positive‐Staining Transmission Electron Microscopy of Organic Specimens

Advanced Healthcare Materials, EarlyView.
Negative‐ and positive‐staining TEM is essential for rapid nanometer‐resolution characterization of organic specimens ranging from nanoparticles to cells. Uranyl salts are widely used negative‐/positive‐stains but are radioactive and highly toxic to users and the environment.
Vera M. Kissling, Stephanie Eitner, Davide Bottone, Gea Cereghetti, Peter Wick   +4 more
wiley   +1 more source

Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer's disease [PDF]

, 2019
Neurofilament light chain (NfL) is a promising fluid biomarker of disease progression for various cerebral proteopathies. Here we leverage the unique characteristics of the Dominantly Inherited Alzheimer Network and ultrasensitive immunoassay technology ...
Allegri, Ricardo, Alzheimer Network, Amtashar, Fatima, Apel, Anja, Barro, Christian, Bateman, Randall, Bateman, Randall J., Benzinger, Tammie, Benzinger, Tammie L. S., Berman, Sarah, Bodge, Courtney, Brandon, Susan, Brooks, William, Buck, Jill, Buckles, Virginia, Chea, Sochenda, Chhatwal, Jasmeer, Chhatwal, Jasmeer, Chrem, Patricio, Chui, Helena, Cinco, Jake, Clifford, Jack, Cruchaga, Carlos, DiBari, Siri Houeland, Donahue, Tamara, Douglas, Jane, D’Mello, Mirelle, Edigo, Noelia, Erekin-Taner, Nilufer, Fagan, Anne, Fagan, Anne M., Farlow, Marty, Farrar, Angela, Feldman, Howard, Flynn, Gigi, Fox, Nick, Franklin, Erin, Fujii, Hisako, Gant, Cortaiga, Gardener, Samantha, Ghetti, Bernardino, Ghetti, Bernardino, Goate, Alison, Goate, Alison M., Goldman, Jill, Gordon, Brian, Gordon, Brian A., Graff-Radford, Neill, Graff-Radford, Neill R., Gray, Julia, Gräber, Susanne, Gurney, Jenny, Hassenstab, Jason, Hirohara, Mie, Holtzman, David, Hornbeck, Russ, Ikeuchi, Takeshi, Ikonomovic, Snezana, Jerome, Gina, Jucker, Mathias, Jucker, Mathias, Kaeser, Stephan A., Karch, Celeste, Kasuga, Kensaku, Kawarabayashi, Takeshi, Klunk, William, Koeppe, Robert, Kuder-Buletta, Elke, Kuder-Buletta, Elke, Kuhle, Jens, LaFougere, Christian, Laske, Christoph, Laske, Christoph, Lee, Jae-Hong, Levin, Johannes, Levin, Johannes, Marcus, Daniel, Martins, Ralph, Martins, Ralph, Mason, Neal Scott, Masters, Colin, Masters, Colin L., Maue-Dreyfus, Denise, McDade, Eric, McDade, Eric M., Montoya, Lucy, Mori, Hiroshi, Morris, John, Morris, John C., Nagamatsu, Akem, Neimeyer, Katie, Noble, James, Noble, James M., Norton, Joanne, Perrin, Richard, Preische, Oliver, Raichle, Marc, Ringman, John, Ringman, John M., Roh, Jee Hoon, Rossor, Martin N., Salloway, Stephen, Salloway, Stephen, Schofield, Peter, Schofield, Peter R., Schultz, Stephanie A., Shimada, Hiroyuki, Shiroto, Tomoyo, Shoji, Mikio, Sigurdson, Wendy, Sohrabi, Hamid, Sparks, Paige, Suzuki, Kazushi, Swisher, Laura, Taddei, Kevin, Vöglein, Jonathan, Wang, Guoqiao, Wang, Jen, Wang, Peter, Weiner, Mike, Wolfsberger, Mary, Xiong, Chengjie, Xu, Xiong   +122 more
core   +1 more source