Results 81 to 90 of about 251,718 (205)

Can Short Peptides Be Inhibitors of Serum Amyloid a Protein Aggregation?

Proceedings, 2019
One of the approaches in the design of anti-amyloid drugs is to find compounds that are able to hamper self-association of amyloidogenic protein molecules. [...]
Sandra Skibiszewska, Elzbieta Jankowska
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Pharmacological removal of serum amyloid P component from intracerebral plaques and cerebrovascular Aβ amyloid deposits in vivo [PDF]

Open Biology, 2016
Human amyloid deposits always contain the normal plasma protein serum amyloid P component (SAP), owing to its avid but reversible binding to all amyloid fibrils, including the amyloid β (Aβ) fibrils in the cerebral parenchyma plaques and cerebrovascular ...
Raya Al-Shawi, Glenys A. Tennent, David J. Millar, Angela Richard-Londt, Sebastian Brandner, David J. Werring, J. Paul Simons, Mark B. Pepys   +7 more
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Co-populated Conformational Ensembles of β(2)-Microglobulin Uncovered Quantitatively by Electrospray Ionization Mass Spectrometry [PDF]

, 2004
Ordered assembly of monomeric human β(2)-microglobulin (β(2)m) into amyloid fibrils is associated with the disorder hemodialysis-related amyloidosis. Previously, we have shown that under acidic conditions (pH
Bjorkman, Cech, Chiti, Chiti, Chowdhury, Dobo, Dobson, Esposito, Felitsyn, Fenn, Fenn, Floege, Ganem, Gejyo, Gejyo, Gorevic, Goto, Grandori, Grandori, Hill, Hoshino, Jones, Kad, Kad, Kaltashov, Karlsson, Katou, Khan, Konermann, Konermann, Kraulis, Mayer, McParland, McParland, Mirza, Morgan, Ohashi, Pitkanen, Robinson, Samalikova, Samalikova, Saper, Selkoe, Siuzdak, Smith, Wanker, Yamaguchi   +46 more
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SErum Amyloid a Protein in Amyloidosis, Rheumatic, and Neoplastic Diseases [PDF]

Arthritis & Rheumatism, 1979
AbstractSerum levels of amyloid protein A (SAA) have been shown to be elevated in different types of amyloidosis and in rheumatic diseases by radioimmunoassay using 125 iodine labeled AA and anti‐AA. SAA levels were elevated in both primary and secondary amyloidosis, but there were highly significant differences between these levels.
M D, Benson, A S, Cohen
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The prevalence and distribution of the amyloidogenic transthyretin (TTR) V122I allele in Africa [PDF]

, 2016
Transthyretin (TTR) pV142I (rs76992529-A) is one of the 113 variants in the human TTR gene associated with systemic amyloidosis. It results from a G to A transition at a CG dinucleotide in the codon for amino acid 122 of the mature protein (TTR V122I ...
Alexander, Alice A, Buxbaum, Joel N., Garvey, W. T, Jacobson, Daniel R, Kalidi, Issa, Modiano, David, Sirima, Sodiomon B, Tagoe, Clement, Tishkoff, Sara, Toure, Amadou, Williams, Scott M   +10 more
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Genetic Effects on Serum Concentrations of Serum Amyloid A Protein [PDF]

Clinical Chemistry, 2004
MacGregor et al. (1) reported a twin-study of the genetic contribution to baseline serum concentrations of two acute-phase proteins, C-reactive protein and serum amyloid A protein (SAA). In their discussion, they stated that no studies had been reported of associations between particular isoforms and different baseline values of SAA.
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Serum Amyloid a Protein in Patients with Acute Myocardial Infarction

Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 1995
The concentrations of four acute phase proteins were measured in sera of 40 patients with acute myocardial infarction (AMI) to evaluate their behaviour from day-to-day and to find out if they can serve for early prediction of postinfarction complications and mortality rate.
Časl, Martin, Šurina, Branka, Glojnarić, Ines, Pape, Ervin, Jagrinec, Nada, Kranjčević, Stjepan   +5 more
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Neonatal-onset multisystem inflammatory disease responsive to interleukin-1 beta inhibition [PDF]

, 2006
BACKGROUND:Neonatal-onset multisystem inflammatory disease is characterized by fever, urticarial rash, aseptic meningitis, deforming arthropathy, hearing loss, and mental retardation.
Adams, BS, Aksentijevich, I, Beitz, LO, Brewer, C, Butman, JA, Canna, SW, Cole, JL, Dailey, NJ, Fuhlbrigge, RC, Gardner, G, Gelabert, A, Goldbach-Mansky, R, Hannan, WP, Haverkamp, MH, Hawkins, PN, Hill, S, Hoffmann, SC, Holland, SM, Horn, W, Jarvis, JN, Jones, J, Karp, BI, Kastner, DL, Kim, HJ, Moore, TL, O'Neil, K, Paul, SM, Penzak, SR, Pham, TH, Pucino, F, Rubin, BI, Shaham, B, Snyder, C, Stein, L, Turner, ML, Vehe, RK, Warren, RW, Wesley, RA, Wiggs, E, Zalewski, C   +39 more
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A Novel Genetic Screen Identifies Modifiers of Age-Dependent Amyloid β Toxicity in the Drosophila Brain [PDF]

, 2017
The accumulation of amyloid β peptide (Aβ) in the brain of Alzheimer's disease (AD) patients begins many years before clinical onset. Such process has been proposed to be pathogenic through the toxicity of Aβ soluble oligomers leading to synaptic ...
Belfiori Carrasco, Lautaro Francisco, Bocai, Nadia Irina, Castaño, Eduardo Miguel, Ceriani, Maria Fernanda, Marcora, Maria Silvina, Morelli, Laura   +5 more
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C-reactive protein and serum amyloid A levels in discriminating malignant from non-malignant pleural effusion

Egyptian Journal of Chest Disease and Tuberculosis, 2015
Introduction: Distinction between malignant and non-malignant pleural effusion is of great importance in the patient management. The aim: We examined the diagnostic value of C-reactive protein (CRP) and serum amyloid A (SAA) in distinguishing different ...
Hala Mohamed Shalaby Samaha, Amany Ragab Elsaid, Rasha Elzehery, Rania Elhelaly   +3 more
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