Results 1 to 10 of about 15,960 (130)

Sarsasapogenin Preserves Podocyte Integrity and Attenuates Renal Injury in Experimental IgA Nephropathy. [PDF]

FASEB J
Experimental IgA nephropathy leads to renal inflammation, fibrosis, podocyte injury, and impaired renal function. Sarsasapogenin treatment attenuated inflammatory and profibrotic signaling, reduced extracellular matrix accumulation, preserved nephrin and podocin expression, improved podocyte ultrastructure, and ameliorated renal histopathological ...
Kumaş M, Canlar Akar D, Gül M, Karadaş E, Kum Özşengezer S, Kulualp K, Yavuz O, Yilmaz O.   +7 more
europepmc   +2 more sources

S100A1 Promotes MDM2-Mediated KLF15 Ubiquitination to Regulate ID1-Driven Tubular Injury in Diabetic Kidney Disease. [PDF]

FASEB J
High glucose upregulates S100A1, enhancing MDM2–KLF15 interaction and K48‐linked ubiquitination of KLF15. Degradation of KLF15 relieves ID1 repression, promoting ID1 upregulation, inflammation, fibrosis, tubular injury, and DKD progression. ABSTRACT Diabetic kidney disease (DKD) is the leading cause of end‐stage renal disease globally.
Zeng Z, Shang J, Chai S, Zhang X, Lv X, Han X, Xu Y, Ma B, Lv Z, Wang R.   +9 more
europepmc   +2 more sources

ANGPTL4 Exacerbates Renal Injury in Diabetic Kidney Disease by Impairing Podocyte Lipophagy via Compromised Lysosomal Degradative Function. [PDF]

Adv Sci (Weinh)
In diabetic kidney disease, elevated podocyte ANGPTL4 is linked to reduced TFEB nuclear localization and compromised lysosomal degradative function. These changes impair podocyte lipophagy and promote lipid‐droplet accumulation and podocyte injury, which may contribute to renal injury progression.
Liu X, Jiang S, Yang Z, Shang S, Li J, Zou G, Zhou C, Li W.   +7 more
europepmc   +2 more sources

Sodium Butyrate Attenuates Renal Fibrosis by Regulating Glycolysis and Histone H4K12 Lactylation in Diabetic Kidney Disease. [PDF]

Diabetes Obes Metab
ABSTRACT Background The role of histone lactylation in diabetes associated renal fibrosis remains poorly defined. In this study, we investigated the contribution of histone H4 lysine 12 lactylation (H4K12la) to abnormal glycolysis and renal fibrogenesis in diabetic kidney disease (DKD) and evaluated sodium butyrate (NaB) as a potential therapeutic ...
He P, Wang M, Mei H, Liu Y, Wang M, Sun H, Peng Y, Ban X, Wang Y, Tang X, Fan Q.   +10 more
europepmc   +2 more sources

Chinese Herbal Formula Shenyi Improves Kidney Injury and Inhibits the Activation of the Alternative Complement Pathway in a Mouse Model of Lupus Nephritis [PDF]

Zhongguo quanke yixue, 2022
Background Lupus nephritis (LN) is one of the serious complications of systemic lupus erythematosus. Relevant studies have shown that the traditional Chinese herbal formula Shenyi (SY) can regulate the body's immunity and inhibit renal fibrosis.
Keng CHEN, Yiyao DENG, Shunlai SHANG, Qinggang LI, Xiangmei CHEN
doaj   +1 more source

Qishen Yiqi Dripping Pill Protects Against Diabetic Nephropathy by Inhibiting the Wnt/β-Catenin and Transforming Growth Factor-β/Smad Signaling Pathways in Rats

Frontiers in Physiology, 2021
Diabetic nephropathy is a severe microvascular complication of diabetes. Qishen Yiqi dripping pill (QYDP) has been reported to be a renal protective drug. However, the mechanisms remain unclear. This study was performed to investigate the mechanisms.
Qian Zhang, Xinhua Xiao, Jia Zheng, Ming Li, Miao Yu, Fan Ping, Tong Wang, Xiaojing Wang   +7 more
doaj   +1 more source

Iron Chelator Deferoxamine Alleviates Progression of Diabetic Nephropathy by Relieving Inflammation and Fibrosis in Rats

Biomolecules, 2023
Diabetic nephropathy (DN) is one of the most devastating diabetic microvascular complications. It has previously been observed that iron metabolism levels are abnormal in diabetic patients. However, the mechanism by which iron metabolism levels affect DN
Yunfei Feng, Li Jia, Wan Ma, Chenying Tian, Huahua Du   +4 more
doaj   +1 more source

Activated Alpha 2-Macroglobulin Is a Novel Mediator of Mesangial Cell Profibrotic Signaling in Diabetic Kidney Disease

Biomedicines, 2021
Diabetic kidney disease (DKD) is caused by the overproduction of extracellular matrix proteins (ECM) by glomerular mesangial cells (MCs). We previously showed that high glucose (HG) induces cell surface translocation of GRP78 (csGRP78), mediating PI3K ...
Jackie Trink, Renzhong Li, Yaseelan Palarasah, Stéphan Troyanov, Thomas E. Andersen, Johannes J. Sidelmann, Mark D. Inman, Salvatore V. Pizzo, Bo Gao, Joan C. Krepinsky   +9 more
doaj   +1 more source

Administration of mesenchymal stem cells in diabetic kidney disease: a systematic review and meta-analysis

Stem Cell Research & Therapy, 2021
Background Mesenchymal stem cell (MSC) therapy shows great promise for diabetic kidney disease (DKD) patients. Research has been carried out on this topic in recent years.
Wenshan Lin, Hong-Yan Li, Qian Yang, Guangyong Chen, Shujun Lin, Chunling Liao, Tianbiao Zhou   +6 more
doaj   +1 more source

Histone lysine-specific demethylase 1 induced renal fibrosis via decreasing sirtuin 3 expression and activating TGF-β1/Smad3 pathway in diabetic nephropathy

Diabetology & Metabolic Syndrome, 2022
Objective Diabetic nephropathy (DN) is the leading cause of end-stage renal disease. Histone lysine-specific demethylase 1 (LSD1) is a flavin-containing amino oxidase that can repress or activate transcription.
Lina Dong, Lei Yu, Jin Zhong
doaj   +1 more source