Results 31 to 40 of about 16,115 (161)

Urinary and serum type II collagen: markers of renal fibrosis

, 1997
Background. The progression of chronic renal failure is characterized by the progressive fibrosis of the kidneys. Such fibrosis reflects the increased deposition of collagens (I, III, and IV) as well as fibronectin within scarred kidneys.
Wild, G., MacNeil, S., El Nahas, A., Brown, C., Dalley, A., Milford-Ward, A., Soylemezoglu, O.   +6 more
core   +1 more source

Inter-α-Inhibitor Impairs TSG-6-Induced Hyaluronan Cross-Linking [PDF]

, 2013
Under inflammatory conditions and in the matrix of the cumulus-oocyte complex (COC), the polysaccharide hyaluronan (HA) becomes decorated covalently with heavy chains (HCs) of the serum glycoprotein inter-α-inhibitor (IαI).
Briggs, David C., Richter, Ralf P., Day, Anthony J., Ralf P. Richter, Baranova, Natalia, Viranga Tilakaratna, Day, Anthony J.; id_orcid, David C. Briggs, Natalia S. Baranova, Tilakaratna, Viranga, Enghild, Jan J., Caroline M. Milner, Baranova, Natalia S., Jan J. Enghild, Milner, Caroline M., Foulcer, Simon J., Simon J. Foulcer, Anthony J. Day   +17 more
core   +1 more source

TGF-beta 1-induced epithelial-to-mesenchymal transition and therapeutic intervention in diabetic nephropathy [PDF]

, 2010
Background/Aims: Epithelial-to-mesenchymal cell transformation (EMT) is the trans-differentiation of tubular epithelial cells into myofibroblasts, an event underlying progressive chronic kidney disease in diabetes, resulting in fibrosis.
Hills, Claire E., Squires, Paul E.
core   +1 more source

Defect‐Engineered BiO2‐X Nanosheets Mediate Sono‐Thermomechanical ECM Remodeling for Hepatocellular Carcinoma Immunotherapy

Advanced Science, EarlyView.
Herein, an ultrasound‐responsive BiO2‐X/siFn1 nanoplatform is developed to overcome anti‐PD‐1 resistance in hepatocellular carcinoma. Upon ultrasound irradiation, the platform downregulates fibronectin expression, while its sonothermal effect softens the dense extracellular matrix and activates antitumor immunity in the tumor microenvironment, thereby ...
Huimin Tian, Shen Zhang, Bolin Wu, Yichi Chen, Haitao Shang, Haoyan Tan, Chunyue Wang, Weichen Xu, Huixiong Xu, Haohao Yin, Wen Cheng   +10 more
wiley   +1 more source

SIRT5‐Mediated Desuccinylation of ACAA2 Protects Against Calcium Oxalate‐Induced Kidney Injury by Regulating Fatty Acid Oxidation to Suppress Mitochondrial Oxidative Injury and Ferroptosis

Advanced Science, EarlyView.
The SIRT5/ACAA2 axis maintains lipid metabolic homeostasis in RTECs by promoting ACAA2 desuccinylation and preserving its stability and enzymatic activity, thereby sustaining FAO and limiting PUFA and PUFA‐containing phospholipid accumulation. Under CaOx stress, SIRT5 downregulation impairs FAO, promotes oxidative stress and ferroptosis, and enhances ...
Qinhong Jiang, Caitao Dong, Yuchen Liu, Yuanquan Lou, Wenlong Lin, Sheng Li, Ziqi He   +6 more
wiley   +1 more source

Antidiabetic and Nephroprotective Effects of Polysaccharide Extract from the Seaweed Caulerpa racemosa in High Fructose-Streptozotocin Induced Diabetic Nephropathy

Diabetes, Metabolic Syndrome and Obesity, 2021
Meng Cao,1 Yan Li,1 Ademola C Famurewa,2 Opeyemi Joshua Olatunji3 1Department of Endocrinology, The First Affiliated Hospital of Xinxiang Medical College, Xinxiang, Henan Province, People’s Republic of China; 2Department of Medical Biochemistry ...
Cao M, Li Y, Famurewa AC, Olatunji OJ
doaj  

Integrated Clinical and Proteomic Profiling of CD19 Chimeric Antigen Receptor T Cell Therapy in Progressive Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Objective To characterize the clinical, immunologic, and proteomic changes associated with CD19 chimeric antigen receptor T cell therapy in patients with progressive systemic sclerosis (SSc). Methods Patients with progressive SSc received CD19 chimeric antigen receptor (CAR)‐T cell therapy and were observed longitudinally for safety, clinical efficacy,
Chenhan Jia, Wanyi Lin, Zhangyi Zhao, Fenglin Wu, Chaoyu Gu, Yuankai Sun, Zhe Ding, Chang Wei, Xinyu Li, Cuiwei Xie, Peng Xia, Zhen Xia, Xuesong Liu, Shaoying Yang, Chunyan Zhang, Hanlin Yin, Liangjing Lu   +16 more
wiley   +1 more source

Methods of prediction and prevention of pre-eclampsia: systematic reviews of accuracy and effectiveness literature with economic modelling [PDF]

, 2008
OBJECTIVES: To investigate the accuracy of predictive tests for pre-eclampsia and the effectiveness of preventative interventions for pre-eclampsia.
Meads, C., P Barton, Mol, BW, C Meads, L Duley, T Roberts, C Hyde, Leeflang, MM, Barton, Pelham, Hyde, CJ, G ter Riet, van der Post, JA, ter Riet, G, Meher, S., M Leeflang, Meher, S, Juarez-Garcia, A, Mol, B. W., Juarez-Garcia, A., Cnossen, JS, van der Post, J., Gupta, Janesh, Duley, L, Leeflang, M., Mol, B., Roberts, T. E., B Mol, J van der Post, Gupta, JK, Cnossen, J., J Cnossen, Barton, P. M., Meads, C. A., Meads, Catherine, Leeflang, M. M., Gupta, J. K., Barton, P., Roberts, T., Gupta, J., Hyde, C., Roberts, Tracy, Duley, L., Hyde, Christopher, Khan, Khalid, Khan, KS, van der Post, J. A., Roberts, TE, Barton, PM, Khan, K. S., A Juarez-Garcia, Cnossen, J. S., ter Riet, G., Kahn, K., S Meher, K Khan, Hyde, C. J., J Gupta, Meads, C A, Cnossen, J S, et al   +59 more
core   +1 more source

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

Dietary Potassium Supplementation Reduces Chronic Kidney Lesions Independent of Blood Pressure in Deoxycorticosterone-Acetate and High Sodium Chloride-Treated Mice

, 2023
We have previously shown that an excess of deoxycorticosterone acetate and high sodium chloride intake (DOCA/salt) in one-renin gene mice induces a high urinary Na/K ratio, hypokalemia, and cardiac and renal hypertrophy in the absence of hypertension ...
Haefliger, J.A., Marc P. Maillard, HAEFLIGER, J.-A., Stephan C. Schäfer, WANG, Q., MAILLARD, M.P., Florian Alonso, SCHÄFER, S.C., Jacques-Antoine Haefliger, ALONSO, F., Qing Wang   +10 more
core   +1 more source