Results 21 to 30 of about 16,115 (161)

The mutability of staphyloccal biofilms [PDF]

, 2010
In their natural environment, bacteria are often found as sessile populations, known as biofilms, typified by surface adherence and extracellular matrix production.
Ryder, Victoria Joanne
core   +6 more sources

Transplantation of human fetal pancreatic progenitor cells ameliorates renal injury in streptozotocin-induced diabetic nephropathy

Journal of Translational Medicine, 2017
Background Diabetic nephropathy (DN) is a severe complication of diabetes mellitus (DM). Pancreas or islet transplantation has been reported to prevent the development of DN lesions and ameliorate or reverse existing glomerular lesions in animal models ...
Yongwei Jiang, Wenjian Zhang, Shiqing Xu, Hua Lin, Weiguo Sui, Honglin Liu, Liang Peng, Qing Fang, Li Chen, Jinning Lou   +9 more
doaj   +1 more source

Pathophysiology of Antigen 85 in Patients With Active Tuberculosis: Antigen 85 Circulates As Complexes With Fibronectin and Immunoglobulin G

, 1999
Antigen 85 (Ag85) complex proteins are major secretory products of Mycobacterium tuberculosis and induce strong cellular and humoral immune responses in infected experimental animals and human beings. We have previously shown that nanogram doses of these
Huygen, K., Newman, T., Godfrey, Henry P., Bentley-Hibbert, S., Quan, X.   +4 more
core   +2 more sources

Fufang Zhenzhu Tiaozhi capsule attenuates renal damage by restoring Th17/Treg balance in diabetic db/db mice

Journal of Holistic Integrative Pharmacy, 2022
Objective: To explore the renal protection effect and mechanism of Fufang Zhenzhu Tiaozhi capsule (FTZ) in diabetic db/db mice in vivo and in vitro. Methods: Male db/m mice were considered as control group, and male db/db mice were considered as diabetic
Yiqi YANG, Haibo TAN, Xiaoyu ZHANG, Minyi HUANG, Weijian BEI, Jiao GUO   +5 more
doaj   +1 more source

Polydatin ameliorates renal fibrosis in a streptozotocin–induced rat model of diabetic nephropathy by inhibiting TLR4/NF-κB signaling [PDF]

, 2021
Purpose: To determine the effects of polydatin (PD) on a streptozotocin (STZ)-induced rat model of diabetic nephropathy (DN) and NRK-52E cells treated with high glucose (HG). Methods: Sprague Dawley rats received 65 mM STZ to model DN in vivo.
Li, Gang, Qiao, Yanhong, Niu, Huimin, Wang, Feng   +3 more
core   +1 more source

Antifibrotic effect of Parthenolide on unilateral ureteric obstruction induced‑kidney injury in rats: the role of mTOR/PI3K/Akt and NF-κB Signaling Pathways [PDF]

Zagazig University Medical Journal
Background: Renal fibrosis (RF) represents advanced stage of kidney injury, characterized by tubulointerstitial inflammation that promotes fibrotic tissue accumulation.
Eman Ahmed Ibrahim, Soad L. Kabil, Ebtsam A Ahmed, Alaa Mohamed El-Sayed El-Ebyary   +3 more
doaj   +1 more source

Clinicopathologic Features and Outcomes in Fibronectin Glomerulopathy: A Case Series of 19 Patients

Frontiers in Medicine, 2020
Aims: To describe the characteristics and prognosis of 19 patients with fibronectin glomerulopathy (FNG) and evaluate prognostic factors associated with poor renal outcomes.Methods: Included in this retrospective study was 19 FNG patients in Nanjing ...
Ti Zhang, Wei Zhang, Ke Zuo, Zhen Cheng
doaj   +1 more source

Rhein Inhibits Proliferation, Extracellular Matrix Deposition, and Inflammation in Mesangial Cells via ROS/Akt Signaling Pathway

Natural Product Communications, 2022
It has been reported that rhein, a Chinese herbal compound, has a potent anti-inflammatory effect on various diseases. However, it remains elusive whether rhein has a protective effect on chronic kidney disease (CKD) and what its underlying mechanism may
Rongbing Xiong, Xiaodi Hu, Shuangyan Hu, Minqi Yao, Xiaojun Fu   +4 more
doaj   +1 more source

Hyperglycemia and Hyperlipidemia Act Synergistically to Induce Renal Disease in LDL Receptor-Deficient BALB Mice [PDF]

, 2004
Diabetic nephropathy is the leading cause of end-stage renal disease in Western countries, but only a portion of diabetic patients develop diabetic nephropathy.
Segerer, Stephan, Spencer, Min W., Mühlfeld, Anja S., Alpers, Charles E., Hudkins, Kelly L., LeBoeuf, Renée C., Kirk, Elizabeth, Mühlfeld, Anja Susanne   +7 more
core   +1 more source

Therapeutic Potential of Thrombomodulin in Renal Fibrosis of Nephrotoxic Serum Nephritis in Wistar-Kyoto Rats

Kidney & Blood Pressure Research, 2020
Background: Recombinant human soluble thrombomodulin (rhTM) was approved in 2008 and has been used for treatment of disseminated intravascular coagulation in Japan.
Nobuhiro Kanazawa, Masayuki Iyoda, Shohei Tachibana, Kei Matsumoto, Yukihiro Wada, Taihei Suzuki, Ken Iseri, Takanori Shibata   +7 more
doaj   +1 more source