Results 61 to 70 of about 16,115 (161)
Kidney International ReportsIntroduction: A US Food and Drug Administration–approved new bromodomain (BRD) and extraterminal (BET) bromine domain antagonist called apabetalone, which targets BRD4, has been shown to increase prebeta-1 high-density lipoprotein (HDL) particles ...
Min Wang +5 more
doaj +1 more source
Cell Proliferation, EarlyView.Renal IRI induces tubular EMT and fibrosis. CD11c+AREG+ DCs mediate the process via AREG‐EGFR axis, serving as promising therapeutic targets. ABSTRACT Renal ischemia–reperfusion injury (RIRI) is a major cause of acute tubular damage and a key driver of maladaptive repair and fibrosis.
Xin Luo +14 more
wiley +1 more source
Serum Level of Metalloproteinase in Patients Infected with Helicobacter Pylori in Ardabil [PDF]
Background & Objectives: Matrix Metalloproteinases (MMPs), a member of photolytic enzyme family, degrade the extra cellular matrix. MMPs have very important roles in physiological and pathological processes.
اتحاد, غلامحسین +3 more
core
Potential Urinary Protein Biomarker Candidates for the Accurate Detection of Prostate Cancer among Benign Prostatic Hyperplasia Patients [PDF]
, 2014 Globally, Prostate cancer (PCa) is the most frequently occurring non-cutaneous cancer, and is the second highest cause of cancer mortality in men. Serum prostate specific antigen (PSA) has been the standard in PCa screening since its approval by the ...
Haj-Ahmad, Yousef
core +1 more source
Therapies for Cardiovascular‐Kidney‐Liver‐Metabolic Syndrome: Reappraisal of Fibrates
Diabetes, Obesity and Metabolism, EarlyView.ABSTRACT Cardiovascular disease, chronic kidney disease (CKD), type 2 diabetes mellitus (T2DM), obesity and metabolic dysfunction‐associated steatohepatitis (MASH) frequently coexist and share overlapping pathophysiology, forming the proposed cardiovascular‐kidney‐liver‐metabolic (CKLM) syndrome.
Virginia Anagnostopoulou +5 more
wiley +1 more source
Autoimmunity and Periodontitis
Journal of Periodontal Research, EarlyView.In a microbe‐driven inflammatory environment, peptidyl‐arginine deiminase (PAD) enzymes from neutrophils and Porphyromonas gingivalis citrullinate both microbial and self‐antigens. B cell presentation of citrullinated or self‐mimicking epitopes activates T cells that assist B cells in antibody isotype switching, affinity maturation, epitope spreading ...
Massimo Costalonga +2 more
wiley +1 more source
The measurement of glomerular basement membrane components and glycated albumin as improved markers of incipient diabetic nephropathy. [PDF]
, 2010 Thesis (M.Sc.)-University of KwaZulu-Natal, Westville, 2010.Diabetes causes early structural changes to the glomerular basement membrane (GBM), which alters its function and leads to loss of protein in urine.
Naidoo, Anban.
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BMC NephrologyBackground Acute kidney injury (AKI) and renal fibrosis are clinical conditions associated with high morbidity and mortality. Renal ischemia–reperfusion (I/R) injury is a major cause of AKI.
Yifei Wang, Qiao Tang, Qian Sun
doaj +1 more source
Linchuang shenzangbing zazhi, 2022 ObjectiveTo explore whether or not mulberry leaf alkaloids can inhibit renal interstitial fibrosis in diabetic nephropathy （DN） rats.MethodsDN rat model was established by a high-fat diet and a tail vein injection of streptozotocin （STZ） in 50 Sprague ...
Feng Wu, Li Wei
doaj
Ion Channel Dysfunction and Therapeutic Targeting in Salivary Gland Disorders
Oral Diseases, EarlyView.ABSTRACT Objective Salivary gland hypofunction and xerostomia represent major clinical complications of radiation therapy, autoimmune disorders such as Sjögren's disease, and inherited epithelial ion transport defects. This review integrates current knowledge on ion channel dysfunction as a central mechanistic driver of salivary gland pathology and ...
Tarek Mohamed Abd El‐Aziz +6 more
wiley +1 more source