Results 51 to 60 of about 61,654 (265)

(1S,3R,8R,11S)-2,2,11-Tribromo-10-bromomethyl-3,7,7-trimethyltricyclo[6.4.0.01,3]dodec-9-ene

IUCrData, 2016
The title compound, C16H22Br4, was synthesized in two steps from β-himachalene, which was isolated from essential oil of the Atlas cedar (cedrus atlantica).
Abdoullah Bimoussa, Aziz Auhmani, My Youssef Ait Itto, Jean-Claude Daran, Abdelwahed Auhmani   +4 more
doaj   +1 more source

Directed enzyme evolution: climbing fitness peaks one amino acid at a time [PDF]

, 2009
Directed evolution can generate a remarkable range of new enzyme properties. Alternate substrate specificities and reaction selectivities are readily accessible in enzymes from families that are naturally functionally diverse.
Arnold, Frances H., Tracewell, Cara A.
core   +2 more sources

Multimodal AI‐Driven Identification of Dehydrocostus Lactone as a Potent Renal Fibrosis Attenuator Targeting IQGAP1

Advanced Science, EarlyView.
Renal fibrosis, a hallmark of CKD, lacks effective treatments. Herein, we developed a multimodal AI model (TCM‐SPred) to identify anti‐fibrotic agents and found that dehydrocostus lactone (DCL) targets IQGAP1 to inhibit Wnt signaling, blocking the interaction between IQGAP1 and CCT3, demonstrating potent anti‐fibrotic activity in vitro and in vivo ...
Weijiang Lin, Wenzhuo Xu, Kang Liu, Ping Wang, Zhenzhen Zhu, Wenyu Lu, Zhe Zheng, Xiaoqian Peng, Xunkai Yin, Shulan Mei, An Pan, Jian Liu, Lihong Hu   +12 more
wiley   +1 more source

Neosuberitenone, a New Sesterterpenoid Carbon Skeleton; New Suberitenones; and Bioactivity against Respiratory Syncytial Virus, from the Antarctic Sponge Suberites sp.

Marine Drugs, 2023
Respiratory syncytial virus (RSV) is a highly contagious human pathogen that poses a significant threat to children under the age of two, and there is a current need for new small molecule treatments. The Antarctic sponge Suberites sp.
Joe Bracegirdle, Stine S. H. Olsen, Michael N. Teng, Kim C. Tran, Charles D. Amsler, James B. McClintock, Bill J. Baker   +6 more
doaj   +1 more source

Functional characterization of the cytochrome P450 monooxygenase CYP71AU87 indicates a role in marrubiin biosynthesis in the medicinal plant Marrubium vulgare. [PDF]

, 2019
BackgroundHorehound (Marrubium vulgare) is a medicinal plant whose signature bioactive compounds, marrubiin and related furanoid diterpenoid lactones, have potential applications for the treatment of cardiovascular diseases and type II diabetes.
Addison, J Bennett, Dhanota, Puja, Fiehn, Oliver, Karunanithi, Prema S, Tong, Shen, Zerbe, Philipp   +5 more
core   +6 more sources

Structural Revision of the C16 Sesquiterpene Hegelenether and the Mechanism of C6‐Methylation in Terpene Biosynthesis

Angewandte Chemie International Edition, EarlyView.
The structure of the non‐canonical C16 sesquiterpene named hegelenether was revised to the structure of marxdiol, and its absolute configuration was assigned. Isotopic labeling experiments revealed the stereochemical course of the methyltransferase involved in its biosynthesis.
Heng Li, Gregor Schnakenburg, Michael Groll, Jeroen S. Dickschat   +3 more
wiley   +1 more source

Secondary Organic Aerosol Formation from Healthy and Aphid-Stressed Scots Pine Emissions. [PDF]

, 2019
One barrier to predicting biogenic secondary organic aerosol (SOA) formation in a changing climate can be attributed to the complex nature of plant volatile emissions.
Buchholz, Angela, Faiola, Celia L, Holopainen, Jarmo K, Kari, Eetu, Khalaj, Farzaneh, Kivimäenpää, Minna, Miettinen, Pasi, Pullinen, Iida, Schobesberger, Siegfried, Virtanen, Annele, Yli-Juuti, Taina, Ylisirniö, Arttu   +11 more
core  

Chemical investigation of a biologically active schinus molle L. leaf extract [PDF]

, 2019
The pepper tree Schinus molle L. is an evergreen ornamental plant belonging to the Anacardiaceae family, native to South America and widespread throughout the world. It has biological activities and is used in folk medicine. This paper aims to contribute
Garzoli, S., Masci, V. L., Ovidi, E., Tiezzi, A., Turchetti, G., Zago, D.   +5 more
core   +1 more source

Valorization of the peel and husk of guaraná (Paullinia cupana): oil extraction, chemical composition, cytotoxicity, and antitumor potential

Biofuels, Bioproducts and Biorefining, EarlyView.
Abstract Guaraná (Paullinia cupana) is a fruit native to the Amazon region. Due to its widespread use, primarily in beverages, its production has grown over the years. The seed is the only commercially valuable part of the fruit so the guaraná production chain generates byproducts, including peel, husk, and spent seed.
Leiliane do Socorro Sodré de Souza, Guilherme Teixeira de Azevedo, Eduardo Leonarski, Giovana Lima de Souza, Rafael Lopes e Oliveira, Sérgio Duvoisin Junior, Karina Cesca, Débora de Oliveira, Anderson Mathias Pereira, Ariane Mendonça Kluczkovski   +9 more
wiley   +1 more source

Genomic Analysis of Terpene Synthase Family and Functional Characterization of Seven Sesquiterpene Synthases from Citrus sinensis

Frontiers in Plant Science, 2017
Citrus aroma and flavor, chief traits of fruit quality, are derived from their high content in essential oils of most plant tissues, including leaves, stems, flowers, and fruits.
Berta Alquézar, Berta Alquézar, Ana Rodríguez, Ana Rodríguez, Marcos de la Peña, Leandro Peña, Leandro Peña   +6 more
doaj   +1 more source