Results 51 to 60 of about 6,360 (195)

Effects of different phosphate lowering strategies in patients with CKD on laboratory outcomes: A systematic review and NMA.

PLoS ONE, 2017
BackgroundChronic kidney disease-mineral and bone disorder (CKD-MBD), a complication of chronic kidney disease, has been linked to reduced quality and length of life. High serum phosphate levels that result from CKD-MBD require phosphate-lowering agents,
Nigar Sekercioglu, Argie Angeliki Veroniki, Lehana Thabane, Jason W Busse, Noori Akhtar-Danesh, Alfonso Iorio, Luciane Cruz Lopes, Gordon H Guyatt   +7 more
doaj   +1 more source

The Effect of Sevelamer on Serum Levels of Gut-Derived Uremic Toxins: Results from In Vitro Experiments and A Multicenter, Double-Blind, Placebo-Controlled, Randomized Clinical Trial

Toxins, 2019
High serum levels of gut-derived uremic toxins, especially p-cresyl sulfate (pCS), indoxyl sulfate (IS) and indole acetic acid (IAA), have been linked to adverse outcomes in patients with chronic kidney disease (CKD).
Youssef Bennis, Yan Cluet, Dimitri Titeca-Beauport, Najeh El Esper, Pablo Ureña, Sandra Bodeau, Christian Combe, Bertrand Dussol, Denis Fouque, Gabriel Choukroun, Sophie Liabeuf   +10 more
doaj   +1 more source

Sevelamer Use in End-Stage Kidney Disease (ESKD) Patients Associates with Poor Vitamin K Status and High Levels of Gut-Derived Uremic Toxins: A Drug–Bug Interaction?

Toxins, 2020
Gut microbial metabolism is not only an important source of uremic toxins but may also help to maintain the vitamin K stores of the host. We hypothesized that sevelamer therapy, a commonly used phosphate binder in patients with end-stage kidney disease ...
Lu Dai, Björn K. Meijers, Bert Bammens, Henriette de Loor, Leon J. Schurgers, Abdul Rashid Qureshi, Peter Stenvinkel, Pieter Evenepoel   +7 more
doaj   +1 more source

Genetic Determinants of Phosphate Response in Drosophila [PDF]

, 2012
Phosphate is required for many important cellular processes and having too little phosphate or too much can cause disease and reduce life span in humans.
A Bevington, A Friedman, A Kaffman, A Martin, Adam Friedman, Arunachalam Vinayagam, Bonnie Berger, C Bergwitz, C Bergwitz, C Bergwitz, Charles DeRobertis, Clemens Bergwitz, D Baldridge, D Nair, DA Mason, E Hesse, E Ito, E Laplantine, E Moallem, E Sprecher, F Rossi, Fanis Missirlis, G Huang, GM Chertow, GR Beck Jr, H Steller, HS Tenenhouse, HT Gazda, HW Zhao, IC Lopez-Mejia, IT Flockhart, J Tower, JA Dow, JJ Tong, Joanne Huang, Jonathan Cohen, JR Stubbs, JT Eppig, K Engel, K Mansfield, K Morishita, LA Perkins, Lawrence B. Mensah, Lizabeth A. Perkins, M Dinur, M Julien, M Mizobuchi, M Nechama, M Nechama, M Ohnishi, M Ohnishi, M Yamazaki, Mark J. Wee, MB Eisen, ME Kraus, ME Lenburg, Meghana Kulkarni, Michael Schnall-Levin, MS Razzaque, MY Zhang, Norbert Perrimon, OJ Dunn, OM Gutierrez, P Ferrigno, PR Gardner, R Kilav, R Lyne, RD Page, RK Smith, RS Edgecomb, S Jan De Beur, S Khoshniat, S Yanagawa, SC Hou, SE McGuire, SH Chang, Stephanie E. Mohr, Sumi Sinha, TM Schroeder, VI Perez, VI Perez, VR Chintapalli, W Huang da, Y Hu, Y Oshima, Y Yoshiko, Yanhui Hu   +86 more
core   +4 more sources

Calciphylaxis Post‐Renal Transplantation: Two Cases and a Literature Review

Organ Medicine, Volume 2, Issue 4, Page 153-159, December 2025.
Calciphylaxis post‐renal transplant is a life‐threatening vasculopathy with high mortality. We report two cases managed successfully via early histopathological diagnosis and intravenous sodium thiosulfate therapy. Early diagnosis and intervention, along with renal function recovery, positively impact prognosis, highlighting the clinical relevance of ...
Luhao Liu, Rongxin Chen, Yuhe Guo, Ziqing Guo, Peng Zhang, Wei Yin, Guanghui Li, Jiali Fang, Zheng Chen   +8 more
wiley   +1 more source

Sevelamer, a phosphate-binding resin with beneficial effect in diabetic kidney disease; a modern paradigm shift [PDF]

, 2014
The proportion of individuals diagnosed with diabetes mellitus is increasing throughout the world, which sequentially drives upward the global frequency of diabetic kidney disease (1, 2). Diabetes is a costly and deadly disease.
Baradaran, Azar., Beladi Mousavi, Seyed seifollah., Mardani, Saeed., Shahbazian, Heshmatollah., Tamadon, Mohammad Reza.   +4 more
core  

Single Center, Open‐Label, Randomized Crossover Trial on Drug–Drug Interactions of Levothyroxine/Magnesium‐Citrate and Levothyroxine/Magnesium‐Aspartate in Healthy Subjects—The ThyroMag Trial

Clinical and Translational Science, Volume 18, Issue 11, November 2025.
ABSTRACT Divalent cations such as calcium and ferrous sulfate interfere with the absorption of levothyroxine due to complexing. To our knowledge, the effects of magnesium on levothyroxine absorption have never been studied. The open‐label cross‐over pharmacokinetic study was conducted in 15 healthy, euthyroid adults.
Martin Christian Attinger, Stefanie von Felten, Claudia Lourenço Rodrigues, Jan Krützfeldt, Lorenz Risch, Jérôme Bonzon   +5 more
wiley   +1 more source

Comparison of efficacy of the phosphate binders nicotinic acid and sevelamer hydrochloride in hemodialysis patients

Saudi Journal of Kidney Diseases and Transplantation, 2012
Hyperphosphatemia is a significant risk factor for the development of ectopic calcification and coronary artery diseases in patients on hemodialysis (HD), and must be controlled with the use of phosphate binders.
Farrokhlagha Ahmadi, Fatemeh Shamekhi, Mahbob Lessan-Pezeshki, Mohammad Reza Khatami   +3 more
doaj   +1 more source

Development of Deferoxamine‐Functionalized Cyclodextrin Polymer for Targeted Iron Chelation

ChemistryOpen, Volume 14, Issue 10, October 2025.
The cyclodextrin polymer is conjugated with 35 deferoxamine units and can form iron(III) complexes. The polymer exhibits significantly lower antiproliferative activity than free deferoxamine. The cyclodextrin polymer with multiple deferoxamine units may present a promising strategy for improving the efficacy of iron chelation therapies.
Roberta Panebianco, Maurizio Viale, Graziella Vecchio   +2 more
wiley   +1 more source

A comparative study of phosphate binders in patients with end stage kidney disease undergoing hemodialysis

Saudi Journal of Kidney Diseases and Transplantation, 2014
In the present study, a comparative evaluation of the effects of calcium acetate, calcium carbonate, sevelamer hydrochloride and lanthanum carbonate was carried out in 120 patients with end stage kidney disease (ESKD) undergoing hemodialysis. Biochemical
Viken A Prajapati, Varsha J Galani, Pankaj R Shah   +2 more
doaj   +1 more source