Results 111 to 120 of about 3,446,938 (405)

Siblings, asthma, rhinoconjunctivitis and eczema: a worldwide perspective from the International Study of Asthma and Allergies in Childhood. [PDF]

, 2014
BACKGROUND: Associations of larger families with lower prevalences of hay fever, eczema and objective markers of allergic sensitization have been found fairly consistently in affluent countries, but little is known about these relationships in less ...
Aït-Khaled, N, Foliaki, S, ISAAC Phase Three Study Group, Mallol, J, Odhiambo, J, Pearce, N, Strachan, DP, Williams, HC   +7 more
core   +2 more sources

Targeting treatable traits in severe asthma: a randomised controlled trial

European Respiratory Journal, 2019
Rationale Treatable traits have been proposed as a new paradigm for airway disease management. Objectives To characterise treatable traits in a severe asthma population and to determine the efficacy of targeting treatments to these treatable traits in ...
V. McDonald, Vanessa L. Clark, Laura Cordova-Rivera, P. Wark, K. Baines, P. Gibson   +5 more
semanticscholar   +1 more source

MiR‐221‐3p Attenuates IL‐33‐Induced Mast Cell Cytokine Expression by Targeting KIT

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Mast cells (MCs) are involved in type 2 inflammation in chronic rhinosinusitis with nasal polyps (CRSwNP), which depends on interleukin (IL)‐33 stimulation. MiR‐221 is reported to be an important regulator of MCs, and miR‐221‐3p can be expressed in CRSwNP. However, the role of miR‐221‐3p in CRSwNP is unclear. Methods Ethmoid tissues
Ruowu Liu, Jiao Zhou, Jing Zhou, Feng Liu, Yafeng Liu, Juan Meng, Luo Ba, Hengyi Xiao, Shixi Liu, Nan Zhang, Claus Bachert, Jintao Du   +11 more
wiley   +1 more source

Increasing prevalence of asthma diagnosis and symptoms in children is confined to mild symptoms [PDF]

, 2001
BACKGROUND: The prevalence of childhood asthma is increasing but few studies have investigated trends in asthma severity. We investigated trends in asthma diagnosis and symptom morbidity between an eight year time period in a paired prevalence study.
Billings, C., Das, C., Duggan, R., Ng Man Kwong, G., Powell, C.V.E., Primhak, R.A., Proctor, A., Whyte, M.K.B.   +7 more
core   +2 more sources

Prevalence and management of severe asthma in primary care: an observational cohort study in Sweden (PACEHR)

Respiratory Research, 2018
Background Severe and uncontrolled asthma is associated with increased risk of exacerbations and death. A substantial proportion of asthma patients have poor asthma control, and a concurrent COPD diagnosis often increases disease burden. The objective of
Kjell Larsson, Björn Ställberg, Karin Lisspers, Gunilla Telg, Gunnar Johansson, Marcus Thuresson, Christer Janson   +6 more
doaj   +1 more source

Superior Benefits of Combining Mepolizumab With Sinus Surgery Compared to Mepolizumab Alone: Results From a Randomised 6‐Month Trial

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis with nasal polyps (CRSwNP) significantly impacts patients’ quality of life (QoL). Standard treatments include nasal irrigations, nasal steroids, systemic corticosteroids, and functional endoscopic sinus surgery (FESS).
Anne‐Sophie Homøe, Kasper Aanæs, Jens Even Tidemandsen, Haase Christiane Holbaek, Rubek Niclas, Samuelsen Grethe Badsberg, Larsen Bent Ivan Holmegaard, Vibeke Backer   +7 more
wiley   +1 more source

RETRACTED: Artificial intelligence for emergency medical care

Health Care Science, EarlyView., 2023
‘Applications of artificial intelligence in emergency medical service’. Abstract There is increasing research into the potential benefits of incorporating artificial intelligence (AI) and machine learning algorithms into emergency medical services. AI is finding new applications across a wide range of sectors, one of which is healthcare, where it is ...
Shivam Rajput, Pramod Kumar Sharma, Rishabha Malviya   +2 more
wiley   +1 more source

Gender aspects and influence of hormones on bronchial asthma – Secondary publication and update

World Allergy Organization Journal, 2017
There is good evidence for gender-specific differences in asthma regarding all affected areas, from intra- to extra-cellular mediators to the whole organ structure und functioning of the lung.
Iris Koper, Karin Hufnagl, Rainer Ehmann
doaj   +1 more source

Interleukin-5 in the Pathophysiology of Severe Asthma

Frontiers in Physiology, 2019
Interleukin-5 (IL-5) exerts a central pathogenic role in differentiation, recruitment, survival, and degranulation of eosinophils. Indeed, during the last years, significant advances have been made in our understanding of the cellular and molecular ...
C. Pelaia, G. Paoletti, F. Puggioni, F. Racca, G. Pelaia, G. Canonica, E. Heffler   +6 more
semanticscholar   +1 more source

Differential Immune Cell Infiltration in Eosinophilic and Non‐Eosinophilic CRS: Correlations With Clinical, Endoscopic, and Radiological Findings

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background The pathogenesis of inflammation in eosinophilic chronic rhinosinusitis (ECRS) and non‐eosinophilic chronic rhinosinusitis (NECRS) remains poorly understood. This study aimed to assess immune cell infiltration within the sinonasal microenvironment in these conditions.
Katarzyna Czerwaty, Katarzyna Piszczatowska, Mirosław J. Szczepański, Natalia Jermakow, Nils Ludwig, Karolina Dżaman   +5 more
wiley   +1 more source