Results 111 to 120 of about 3,688,287 (401)

Prevalence and management of severe asthma in primary care: an observational cohort study in Sweden (PACEHR)

Respiratory Research, 2018
Background Severe and uncontrolled asthma is associated with increased risk of exacerbations and death. A substantial proportion of asthma patients have poor asthma control, and a concurrent COPD diagnosis often increases disease burden. The objective of
Kjell Larsson, Björn Ställberg, Karin Lisspers, Gunilla Telg, Gunnar Johansson, Marcus Thuresson, Christer Janson   +6 more
doaj   +1 more source

The Correlation between Atopy Level and Asthma Manifestation in Children 3-10 Years of Age at The Pulmonary Community Health Center (Bbkpm) Surakarta, Central Java [PDF]

, 2018
Background: Asthma is a chronic inflammation of the airways that involves many cells and their elements. In Indonesia, the incidence of asthma in children ranges from 2 to 30% and it causes the loss of child’s school days.
Rahayuningrum, I. O. (Indriyati), Sari, R. (Riana), Supraba, R. D. (Rosinta)   +2 more
core   +1 more source

Interleukin-5 in the Pathophysiology of Severe Asthma

Frontiers in Physiology, 2019
Interleukin-5 (IL-5) exerts a central pathogenic role in differentiation, recruitment, survival, and degranulation of eosinophils. Indeed, during the last years, significant advances have been made in our understanding of the cellular and molecular ...
C. Pelaia, G. Paoletti, F. Puggioni, F. Racca, G. Pelaia, G. Canonica, E. Heffler   +6 more
semanticscholar   +1 more source

Population‐Based Multi‐Omics and Cohort Study Identifying Predictive Biomarkers and Therapeutic Targets for Psoriatic Disease

Advanced Science, EarlyView.
Psoriatic disease (PsD) is a chronic skin disease, with challenges in early risk stratification and drug development. Through gene‐level causal inference framework and expression level validation, combined with longitudinal cohort study, CDSN and PRSS8 have been identified as candidate biomarkers and therapeutic targets for PsD.
Tianxing Wu, Jialiang Luo, Haoyuan Qiu, Weijie Shao, Yueyang Lu, Meixuan Luo, Zhaofeng Lin, Yan Zhang, Libo Zhang, Hong Wang, Jia Zhou, Guangfeng Ruan, Peihua Cao, Daming Zuo   +13 more
wiley   +1 more source

Reliability, Satisfaction and Effectiveness of Benralizumab Home Self-Administration in Patients with Severe Eosinophilic Asthma in Real-World Practice: The Auto-Benra Study

Journal of Asthma and Allergy, 2022
Ismael García-Moguel,1,2 Ana Rosado,3 Aída Gómez-Cardeñosa,4,5 Mar Gandolfo-Cano,6,7 Teresa Robledo Echarren,8 Maria del Mar Moro Moro,9 Mª del Mar Reaño Martos,10 Rafael Pineda-Pineda,11 Marcela Valverde-Monge,4,5 Cristina Martin-Arriscado Arroba,12 ...
García-Moguel I, Rosado A, Gómez-Cardeñosa A, Gandolfo-Cano M, Robledo Echarren T, Moro Moro MDM, Reaño Martos MDM, Pineda-Pineda R, Valverde-Monge M, Martin-Arriscado Arroba C, Domínguez-Ortega J   +10 more
doaj  

Severe asthma in children: Evaluation and management

Allergology International, 2019
Severe asthma in children is associated with significant morbidity. Children with severe asthma are at increased risk for adverse outcomes including medication-related side effects, life-threatening exacerbations, and impaired quality of life.
Mehtap Haktanir Abul, Wanda Phipatanakul
doaj   +1 more source

Metalloproteinases and their Inhibitors under the Course of Immunostimulation by CPG-ODN and Specific Antigen Inhalation in Equine Asthma [PDF]

, 2019
Objectives. Inhalation of immunostimulatory bacterial DNA segments (cytosine-phosphate-guanosine-oligodeoxynucleotides, CpG-ODN) normalizes clinical and cytologic parameters in severe equine asthma.
Barton, Ann Kristin, Einspanier, Ralf, Gehlen, Heidrun, Geis, Sabine, Klier, John, Shety, Tarek   +5 more
core   +1 more source

IL‐4/STAT6‐signaling Influences Local Inflammation and Regeneration Processes During Acute Pancreatitis and Promotes Fibrosis by a Direct Activation of Pancreatic Fibroblasts During Chronic Pancreatitis

Advanced Science, EarlyView.
IL‐4/IL‐13/STAT6 signaling plays a crucial for the suppression of pro‐inflammation during acute pancreatitis and supports acinar cell regeneration but has only minor impact on fibrogenesis during chronic form of the disease. IL‐4/IL‐13 induce the expression of certain collagens directly in pancreatic fibroblasts via STAT6 activation, whereas ...
ElSheikh H, Salvers A, Piesker J, Buchholz S, Lange R, Ameling S, Steil L, Hammer E, Homuth G, Völker U, Bröker BM, Weiss FU, Sendler M, Glaubitz J   +13 more
wiley   +1 more source

Gender aspects and influence of hormones on bronchial asthma – Secondary publication and update

World Allergy Organization Journal, 2017
There is good evidence for gender-specific differences in asthma regarding all affected areas, from intra- to extra-cellular mediators to the whole organ structure und functioning of the lung.
Iris Koper, Karin Hufnagl, Rainer Ehmann
doaj   +1 more source

Asthma diagnosis and treatment - 1012. The efficacy of budesonide in the treatmetn of acute asthma in children: a double-blind, randomized, controlled trial. [PDF]

, 2013
Background Current evidence suggests that inhaled glucocorticoids (IGC) have a more profound topical none genomic effect on bronchial airways as compared to systemic glucocorticoids.
Al-Ghamdi, N, Al-Tamimi, S, Al-Tannir, M, Alangari, AA, Malhis, N, Mubasher, M, Riaz, M, Umetsu, D   +7 more
core   +1 more source