Results 21 to 30 of about 3,446,938 (405)

Treating severe asthma: Targeting the IL‐5 pathway

Clinical and Experimental Allergy, 2021
Severe asthma is a heterogeneous disease with different phenotypes based on clinical, functional or inflammatory parameters. In particular, the eosinophilic phenotype is associated with type 2 inflammation and increased levels of interleukin (IL)‐4, IL‐5
S. Principe, C. Porsbjerg, Sisse Bolm Ditlev, Ditte Kjaersgaard Klein, Korneliusz Golebski, N. Dyhre-Petersen, Yoni E. van Dijk, J. V. van Bragt, Lente H. M. Dankelman, S. Dahlén, C. Brightling, S. Vijverberg, A. H. Maitland‐van der Zee   +12 more
semanticscholar   +1 more source

Severe Asthma in a General Population Study: Prevalence and Clinical Characteristics

Journal of Asthma and Allergy, 2021
Purpose Current guidelines primarily use medication levels to distinguish severe asthma from other types of asthma. In addition, severe asthma must also be uncontrolled at high-intensity treatment or become uncontrolled if treatment level is decreased ...
Lina Rönnebjerg, Malin Axelsson, H. Kankaanranta, H. Backman, M. Rådinger, B. Lundbäck, L. Ekerljung   +6 more
semanticscholar   +1 more source

Dupilumab modulates specific IgE mite responses at the molecular level in severe T2-high atopic dermatitis: A real-world experience

Frontiers in Medicine, 2022
BackgroundAtopic dermatitis (AD) is regarded as a chronic systemic disease which is characterized by a robust overexpression of type 2 related cytokines, with increased total IgE levels and a concomitant sensitization to common allergens.
Ruperto González-Pérez, Ruperto González-Pérez, Paloma Poza-Guedes, Paloma Poza-Guedes, Elena Mederos-Luis, Inmaculada Sánchez-Machín   +5 more
doaj   +1 more source

EAACI Biologicals Guidelines—Recommendations for severe asthma

Allergy. European Journal of Allergy and Clinical Immunology, 2020
Severe asthma imposes a significant burden on patients, families and healthcare systems. Management is difficult, due to disease heterogeneity, co‐morbidities, complexity in care pathways and differences between national or regional healthcare systems ...
I. Agache, C. Akdis, M. Akdiş, G. Canonica, T. Casale, T. Chivato, J. Corren, D. Chu, S. D. Del Giacco, T. Eiwegger, B. Flood, D. Firinu, J. Gern, E. Hamelmann, N. Hanania, I. Hernández-Martín, R. Knibb, M. Mäkelä, Parameswaran Nair, L. O' Mahony, N. Papadopoulos, A. Papi, Hae‐Sim Park, L. A. Pérez de Llano, O. Pfaar, S. Quirce, J. Sastre, M. Shamji, J. Schwarze, Ó. Palomares, M. Jutel   +30 more
semanticscholar   +1 more source

Severe Eosinophilic Asthma [PDF]

Journal of Clinical Medicine, 2019
Asthma is a heterogeneous disease with varying severity. Severe asthma is a subject of constant research because it greatly affects patients’ quality of life, and patients with severe asthma experience symptoms, exacerbations, and medication side effects.
Agamemnon Bakakos, Stelios Loukides, Petros Bakakos   +2 more
openaire   +2 more sources

Mepolizumab effectiveness and identification of super-responders in severe asthma

European Respiratory Journal, 2020
Severe asthma is a high-burden disease. Real-world data on mepolizumab in patients with severe eosinophilic asthma is needed to assess whether the data from randomised controlled trials are applicable in a broader population.
E. Harvey, D. Langton, C. Katelaris, S. Stevens, C. Farah, A. Gillman, J. Harrington, M. Hew, V. Kritikos, N. Radhakrishna, P. Bardin, M. Peters, P. Reynolds, J. Upham, M. Baraket, S. Bowler, J. Bowden, Jimmy Chien, L. Chung, C. Grainge, C. Jenkins, G. Katsoulotos, Joy Lee, V. McDonald, H. Reddel, J. Rimmer, P. Wark, P. Gibson   +27 more
semanticscholar   +1 more source

Obesity, Inflammation, and Severe Asthma: an Update

Current Allergy and Asthma Reports, 2021
Obesity-associated difficult asthma continues to be a substantial problem and, despite a move to address treatable traits affecting asthma morbidity and mortality, it remains poorly understood with limited phenotype-specific treatments.
Varun Sharma, D. Cowan
semanticscholar   +1 more source

Does asthma impair wealth accumulation or does wealth protect against asthma? [PDF]

, 2016
OBJECTIVE: We investigate the association between adult asthma and wealth, testing whether the disease impairs wealth accumulation (social selection model) or if wealth protects against asthma (social causation model).
Smith, Patricia K., Zagorsky, Jay L.
core   +1 more source

Imaging for precision medicine: can V‐P SPECT measure mepolizumab response in asthma?

Respirology Case Reports, 2021
Monoclonal antibody therapies are effective for many but not all people with severe asthma. Precision medicine guides treatment selection using biomarkers to select patients most likely to respond according to their inflammatory endotypes.
Vanessa M. McDonald, Paola D. Urroz, Marika Bajc, Natalie Rutherford, Bree Brooker, Peter G. Gibson   +5 more
doaj   +1 more source

Biomarkers in Severe Asthma [PDF]

Immunology and Allergy Clinics of North America, 2016
Biomarkers have been critical for studies of disease pathogenesis and the development of new therapies in severe asthma. In particular, biomarkers of type 2 inflammation have proven valuable for endotyping and targeting new biological agents. Because of these successes in understanding and marking type 2 inflammation, lack of knowledge regarding non ...
Wan, Xiao Chloe, Woodruff, Prescott G
openaire   +5 more sources