Results 51 to 60 of about 3,688,287 (401)

Management of severe asthma: a European Respiratory Society/American Thoracic Society guideline

European Respiratory Journal, 2019
This document provides clinical recommendations for the management of severe asthma. Comprehensive evidence syntheses, including meta-analyses, were performed to summarise all available evidence relevant to the European Respiratory Society/American ...
F. Holguin, J. Cardet, K. Chung, S. Diver, D. S. Ferreira, A. Fitzpatrick, M. Gaga, Liz Kellermeyer, S. Khurana, Shandra L. Knight, V. McDonald, R. Morgan, V. Ortega, D. Rigau, P. Subbarao, T. Tonia, I. Adcock, E. Bleecker, C. Brightling, L. Boulet, M. Cabana, M. Castro, P. Chanez, A. Custovic, R. Djukanović, U. Frey, B. Frankemölle, P. Gibson, D. Hamerlijnck, N. Jarjour, S. Konno, Huahao Shen, C. Vitary, A. Bush   +33 more
semanticscholar   +1 more source

Characterisation of patients with severe asthma in the UK Severe Asthma Registry in the biologic era

Thorax, 2020
Background The UK Severe Asthma Registry (UKSAR) is the world’s largest national severe asthma registry collecting standardised data on referrals to UK specialist services.
D. Jackson, J. Busby, P. Pfeffer, A. Menzies-Gow, T. Brown, R. Gore, M. Doherty, A. Mansur, S. Message, R. Niven, M. Patel, L. Heaney   +11 more
semanticscholar   +1 more source

Efficacy and safety of treatment with biologicals (benralizumab, dupilumab, mepolizumab, omalizumab and reslizumab) for severe eosinophilic asthma. A systematic review for the EAACI Guidelines ‐ recommendations on the use of biologicals in severe asthma

Allergy. European Journal of Allergy and Clinical Immunology, 2020
Five biologicals have been approved for severe eosinophilic asthma, a well‐recognized phenotype. Systematic reviews (SR) evaluated the efficacy and safety of benralizumab, dupilumab, mepolizumab, omalizumab and reslizumab (alphabetical order) compared to
I. Agache, Jessica Beltran, C. Akdis, M. Akdiş, C. Canelo-Aybar, W. Canonica, T. Casale, T. Chivato, J. Corren, S. D. Del Giacco, T. Eiwegger, D. Firinu, J. Gern, E. Hamelmann, N. Hanania, M. Mäkelä, I. H. Martín, Parameswaran Nair, L. O’Mahony, N. Papadopoulos, A. Papi, Hae‐Sim Park, L. A. Pérez de Llano, M. Posso, Claudio Rocha, S. Quirce, J. Sastre, M. Shamji, Yang Song, Corinna Steiner, J. Schwarze, P. Alonso-Coello, Ó. Palomares, M. Jutel   +33 more
semanticscholar   +1 more source

Tezepelumab in Adults and Adolescents with Severe, Uncontrolled Asthma.

New England Journal of Medicine, 2021
BACKGROUND Tezepelumab is a human monoclonal antibody that blocks thymic stromal lymphopoietin, an epithelial-cell-derived cytokine implicated in the pathogenesis of asthma.
A. Menzies-Gow, J. Corren, A. Bourdin, G. Chupp, E. Israel, M. Wechsler, C. Brightling, J. Griffiths, A. Hellqvist, K. Bowen, P. Kaur, G. Almqvist, S. Ponnarambil, G. Colice   +13 more
semanticscholar   +1 more source

Recovery of smell sense loss by mepolizumab in a patient allergic to dermatophagoides and affected by chronic rhinosinusitis with nasal polyps [PDF]

, 2019
Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) frequently presents with dysfunction or loss of the sense of smell, resulting in a signifcant impairment in quality of life.
Cavaliere, Carlo, Ciotti, Mario, de Vincentiis, Marco, Frati, Franco, Greco, Antonio, Incorvaia, Cristoforo, Masieri, Simonetta, Messineo, Daniela   +7 more
core   +1 more source

Clinical utility of fractional exhaled nitric oxide in severe asthma management

European Respiratory Journal, 2020
Asthma is a chronic inflammatory disease of the airways, affecting over 350 million people worldwide and placing a significant burden on healthcare providers and wider society.
A. Menzies-Gow, A. Mansur, C. Brightling
semanticscholar   +1 more source

Severe Paediatric Asthma Collaborative in Europe (SPACE):protocol for a European registry [PDF]

, 2018
The development of new asthma biologics and receptor blockers for the treatment of paediatric severe asthma raises challenges. It is unclear whether there are sufficient children in Europe to recruit into randomised placebo-controlled trials to establish
Carlsen, Karin C.L., Chalmers, James D., Coleman, Courtney, Cunningham, Steve, Fernandes, Ricardo M., Fleming, Louise J., Gappa, Monika, Grigg, Jonathan, Karadag, Bülent, Liu, Norrice M., Midulla, Fabio, Pijnenburg, Marielle W.H., Rusconi, Franca, Rutjes, Niels W., van Aalderen, Wim   +14 more
core   +10 more sources

Experience with mepolizumab in adults with severe eosinophilic asthma: a case series from India

Respirology Case Reports, 2021
Severe asthma can be associated with eosinophilic or allergic phenotypes or both. Eosinophilic inflammation is associated with exacerbations and disease severity due to biological activity of interleukin‐5 (IL‐5).
Venkata Nagarjuna Maturu, Priti Meshram, Soumya Das, Ashok Kumar Rajput, Arun Chowdary Kotaru, Bhavesh Kotak, Neeraj Markandeywar, Simran Chhatwal   +7 more
doaj   +1 more source

The Portuguese Severe Asthma Registry: Development, Features, and Data Sharing Policies [PDF]

, 2018
The Portuguese Severe Asthma Registry (Registo de Asma Grave Portugal, RAG) was developed by an open collaborative network of asthma specialists. RAG collects data from adults and pediatric severe asthma patients that despite treatment optimization and ...
Arrobas, A, Costa, A, Costa, C, et al., Costa, T, Drummond, M, Farinha, P, Fernandes, B, Ferreira, A, Fonseca, JA, Longo, C, Loureiro, C, Mendes, A, Pardal, C, Pereira, AM, Rocha, P, Soares, J, Sokolova, A, Sá-Sousa A1, A, Todo-Bom, A, Videira, W   +19 more
core   +1 more source

Clinical characteristics of complete responders versus non-complete responders to omalizumab, benralizumab and mepolizumab in patients with severe asthma: a long-term retrospective analysis

Annals of Medicine
Background Some patients with severe asthma may benefit from treatment with biologics, but evidence has been mostly collected from randomized controlled trials (RCTs), in which patients’ characteristics are different from those encountered in asthma ...
Maria Basagaña, Carlos Martínez-Rivera, Clara Padró, Ignasi Garcia-Olivé, Mimar Martínez-Colls, Juan Navarro, Laura Pardo, Paula Cruz, Gloria Cardona Peitx, Lídia Carabias, Albert Roger, Jorge Abad, Antoni Rosell   +12 more
doaj   +1 more source