Results 31 to 40 of about 45,012 (247)

Investigation of Known Genetic Mutations of Arabian Horses in Egyptian Arabian Foals with Juvenile Idiopathic Epilepsy. [PDF]

, 2017
BackgroundThe carrier status of lavender foal syndrome (LFS), cerebellar abiotrophy (CA), severe combined immunodeficiency (SCID), and occipitoatlantoaxial malformation (OAAM1) in foals with juvenile idiopathic epilepsy (JIE) is unknown.Hypothesis ...
Aleman, M, Finno, CJ, Penedo, MCT, Weich, K   +3 more
core   +1 more source

Novel Engraftment and T Cell Differentiation of Human Hematopoietic Cells in ART−/−IL2RG−/Y SCID Pigs

Frontiers in Immunology, 2020
Pigs with severe combined immunodeficiency (SCID) are an emerging biomedical animal model. Swine are anatomically and physiologically more similar to humans than mice, making them an invaluable tool for preclinical regenerative medicine and cancer ...
Adeline N. Boettcher, Yunsheng Li, Amanda P. Ahrens, Matti Kiupel, Kristen A. Byrne, Crystal L. Loving, A. Giselle Cino-Ozuna, Jayne E. Wiarda, Jayne E. Wiarda, Jayne E. Wiarda, Malavika Adur, Blythe Schultz, Jack J. Swanson, Elizabeth M. Snella, Chak-Sum (Sam) Ho, Sara E. Charley, Zoe E. Kiefer, Joan E. Cunnick, Ellie J. Putz, Giuseppe Dell'Anna, Jackie Jens, Swanand Sathe, Frederick Goldman, Erik R. Westin, Jack C. M. Dekkers, Jason W. Ross, Christopher K. Tuggle   +26 more
doaj   +1 more source

Regulated progression of B lymphocyte differentiation from cultured fetal liver. [PDF]

, 1987
Lymphoid fetal liver cultures (LFLC) are long-term, nontransformed cultures of early B lymphoid lineage cells which appear developmentally blocked at the pre-B stage in vitro.
Denis, KA, Dorshkind, K, Witte, ON
core   +2 more sources

CD3ε+ Cells in Pigs With Severe Combined Immunodeficiency Due to Defects in ARTEMIS

Frontiers in Immunology, 2020
Severe combined immunodeficiency (SCID) is described as the lack of functional T and B cells. In some cases, mutant genes encoding proteins involved in the process of VDJ recombination retain partial activity and are classified as hypomorphs. Hypomorphic
Adeline N. Boettcher, A. Giselle Cino-Ozuna, Yash Solanki, Jayne E. Wiarda, Jayne E. Wiarda, Jayne E. Wiarda, Ellie Putz, Jeana L. Owens, Sara A. Crane, Amanda P. Ahrens, Crystal L. Loving, Joan. E. Cunnick, Raymond R. R. Rowland, Sara E. Charley, Jack C. M. Dekkers, Christopher K. Tuggle   +15 more
doaj   +1 more source

Establishing Newborn Screening for SCID in the USA: Experience in California

International Journal of Neonatal Screening, 2021
Newborn screening for severe combined immunodeficiency (SCID) has developed from the realization that infants affected with SCID require prompt diagnosis and treatment to avoid fatal infectious complications.
Jennifer M. Puck, Andrew R. Gennery
doaj   +1 more source

Validation of the SCID-hu Thy/Liv mouse model with four classes of licensed antiretrovirals. [PDF]

, 2007
BackgroundThe SCID-hu Thy/Liv mouse model of HIV-1 infection is a useful platform for the preclinical evaluation of antiviral efficacy in vivo.
A Adachi, A Valentin, April N. Kinkade, Barbara Sloan, BD Jamieson, BD Jamieson, BK Berges, BS Robinson, CA Stoddart, CA Stoddart, CA Stoddart, Cheryl A. Bales, Cheryl A. Stoddart, E De Clercq, ED Miller, EJ Freireich, ES Withers-Ward, G Kovalev, George Chkhenkeli, GM Aldrovandi, GM Aldrovandi, GM Aldrovandi, H Kaneshima, H Kaneshima, J McCune, J Mordenti, Jennifer C. Bare, JF Krowka, JM McCune, JM McCune, JM McCune, JM McCune, JM Strizki, José M. Rivera, JY Feng, L Rabin, L Su, L Su, L Zhang, Linqi Zhang, LT Rimsky, M Markowitz, Mary E. Moreno, ME Keir, MG Manz, ML Bonyhadi, ML Greenberg, Paul L. Black, PS Koka, R Datema, R Namikawa, R Namikawa, RC Bast, RD Berkowitz, RD Berkowitz, RD Berkowitz, RD Berkowitz, RG Amado, Rollie E. Ronquillo, S Baenziger, S Gartner, S Gorantla, SD Young, SG Kitchen, SG Kitchen, SK Stanley, Sofiya A. Galkina, Z Sun   +67 more
core   +4 more sources

Generation and Characterization of Severe Combined Immunodeficiency Rats

Cell Reports, 2012
Severe combined immunodeficiency (SCID) mice, the most widely used animal model of DNA-PKcs (Prkdc) deficiency, have contributed enormously to our understanding of immunodeficiency, lymphocyte development, and DNA-repair mechanisms, and they are ideal ...
Tomoji Mashimo, Akiko Takizawa, Junya Kobayashi, Yayoi Kunihiro, Kazuto Yoshimi, Saeko Ishida, Koji Tanabe, Ami Yanagi, Asato Tachibana, Jun Hirose, Jun-ichiro Yomoda, Shiho Morimoto, Takashi Kuramoto, Birger Voigt, Takeshi Watanabe, Hiroshi Hiai, Chise Tateno, Kenshi Komatsu, Tadao Serikawa   +18 more
doaj   +1 more source

Overview of 15-year severe combined immunodeficiency in the Netherlands: towards newborn blood spot screening [PDF]

, 2015
Severe combined immune deficiency (SCID) is a fatal primary immunodeficiency usually presenting in the first months of life with (opportunistic) infections, diarrhea, and failure to thrive. Hematopoietic stem cell transplantation (HSCT) and gene therapy (
Bredius, R.G.M. (Robbert), Burg, M. (Mirjam) van der, Driessen, G.J.A. (Gertjan), Kuijpers, T.W. (Taco W.), Montfrans, J.M. (Joris) van, Pagter, A.P.J. (Anne) de, Tramper, J. (Jelco)   +6 more
core   +1 more source

RAG-1 Mutations Associated with B-Cell-Negative SCID Dissociate the Nicking and Transesterification Steps of V(D)J Recombination [PDF]

, 2001
Some patients with B-cell-negative severe combined immune deficiency (SCID) carry mutations in RAG-1 or RAG-2 that impair V(D)J recombination. Two recessive RAG-1 mutations responsible for B-cell-negative SCID, R621H and E719K, impair V(D)J recombination
Chang, Fu-Chung, Desiderio, Stephen, Li, Wenhui   +2 more
core   +2 more sources

Immunodeficiency in DiGeorge Syndrome and Options for Treating Cases with Complete Athymia. [PDF]

, 2013
The commonest association of thymic stromal deficiency resulting in T-cell immunodeficiency is the DiGeorge syndrome (DGS). This results from abnormal development of the third and fourth pharyngeal arches and is most commonly associated with a ...
Davies, EG
core   +5 more sources