Results 61 to 70 of about 45,777 (283)

Natural killer (NK) cells are present in mice with severe combined immunodeficiency (scid).

Journal of Immunology, 1985
Spleen cells from C.B- 17 scid mice with severe combined immunodeficiency disease exhibit natural killer cell (NK) activity against YAC lymphoma targets in a standard 4-hr 51Cr release assay.
K. Dorshkind, S. Pollack, M. Bosma, R. A. Phillips   +3 more
semanticscholar   +1 more source

Clinical heterogeneity can hamper the diagnosis of patients with ZAP70 deficiency [PDF]

, 2008
One of the severe combined immunodeficiencies (SCIDs), which is caused by a genetic defect in the signal transduction pathways involved in T-cell activation, is the ZAP70 deficiency.
A Fischer, B Mazer, Barbara H. Barendregt, C Cunningham-Rundles, CM Roifman, E Arpaia, F Rieux-Laucat, FD Goldman, Hasibe Artac, Ilhan Tezcan, Ismail Reisli, Jacques J. M. van Dongen, K Katamura, K Masternak, LA Miosge, MC Zelm van, ME Elder, ME Elder, ME Elder, Mirjam van der Burg, N Noraz, O Calle-Martin de la, Ozden Sanal, RH Buckley, RH Buckley, RS Geha, S Matsuda, S Toyabe, Sandra de Bruin-Versteeg, Tuba Turul   +29 more
core   +5 more sources

Newborn Screening for Severe Combined Immunodeficiency in Israel

International Journal of Neonatal Screening, 2017
Newborn screening (NBS) programs for severe combined immunodeficiency (SCID), the most severe type of primary immunodeficiency, are being implemented in more and more countries with every passing year.
Erez Rechavi, Atar Lev, Talia Saraf-Levy, Amos Etzioni, Shlomo Almashanu, Raz Somech   +5 more
doaj   +1 more source

Pulmonary Radiological Manifestations of Humoral and Combined Immunodeficiencies in a Tertiary Pediatric Center

Iranian Journal of Allergy, Asthma and Immunology, 2021
Respiratory diseases are considered as significant causes of morbidity and mortality in primary immunodeficiencies. This study aimed to reveal the radiologic patterns of thoracic involvement in these disorders.
Mitra Khalili, Hossein Farzi, Sepideh Darougar, Fatemeh Hajijoo, Mehrnaz Mesdaghi, Mahboubeh Mansouri, Delara Babaie, Amir Hashemitari, Narges Eslami, Zahra Chavoshzadeh   +9 more
doaj   +1 more source

Induced Pluripotent Stem Cell Meets Severe Combined Immunodeficiency [PDF]

Cell Journal, 2020
Severe combined immunodeficiency (SCID) is classified as a primary immunodeficiency, which is characterized by impaired T-lymphocytes differentiation. IL2RG, IL7Ralpha, JAK3, ADA, RAG1/RAG2, and DCLE1C (Artemis) are the most defective genes in SCID.
Reza Kouchaki, Bahareh Abd-Nikfarjam, Amirhosein Maali, Saeid Abroun, Farshad Foroughi, Sasan Ghaffari, Mehdi Azad   +6 more
doaj   +1 more source

Absence of ZAP-70 prevents signaling through the antigen receptor on peripheral blood T cells but not on thymocytes. [PDF]

, 1995
Recently, a severe combined immunodeficiency syndrome with a deficiency of CD8+ peripheral T cells and a TCR signal transduction defect in peripheral CD4+ T cells was associated with mutations in ZAP-70.
Gelfand, EW, Kadlecek, TA, Mazer, BD, Weinberg, K, Weiss, A   +4 more
core   +2 more sources

LDLR-Gene therapy for familial hypercholesterolaemia: Problems, progress, and perspectives [PDF]

, 2010
Coronary artery diseases (CAD) inflict a heavy economical and social burden on most populations and contribute significantly to their morbidity and mortality rates.
Al-Allaf, FA, Coutelle, C, David, A, Harbottle, R, Themis, M, Waddington, SN   +5 more
core   +3 more sources

Severe Combined Immunodeficiency Disorder due to a Novel Mutation in Recombination Activation Gene 2: About 2 Cases

Case Reports in Immunology, 2021
Severe combined immunodeficiency (SCID) comprises a heterogeneous group of inherited immunologic disorders with profound defects in cellular and humoral immunity. SCID is the most severe PID and constitutes a pediatric emergency.
Ibtihal Benhsaien, Fatima Ailal, Khadija Elazhary, Jalila El bakkouri, Abdallah Badou, Ahmed Aziz Bousfiha   +5 more
doaj   +1 more source

Case Report: Rotavirus Vaccination and Severe Combined Immunodeficiency in Japan

Frontiers in Immunology, 2022
Severe combined immunodeficiency (SCID) is an inborn error of immunity that occurs in approximately 1 in 50,000 births, mainly due to impaired lymphocyte differentiation.
Kay Tanita, Yoshiki Kawamura, Hiroki Miura, Noriko Mitsuiki, Takahiro Tomoda, Kento Inoue, Akihiro Iguchi, Akihiro Iguchi, Masafumi Yamada, Taro Yoshida, Hideki Muramatsu, Norimasa Tada, Toshihiro Matsui, Motohiro Kato, Katsuhide Eguchi, Masataka Ishimura, Shouichi Ohga, Kohsuke Imai, Tomohiro Morio, Tetsushi Yoshikawa, Hirokazu Kanegane   +20 more
doaj   +1 more source

Facilitated engraftment of human hematopoietic cells in severe combined immunodeficient mice following a single injection of Cl²MDP liposomes [PDF]

, 1997
Transplantation of normal and malignant human hematopoietic cells into severe combined immunodeficient (SCID) mice allows for evaluation of long-term growth abilities of these cells and provides a preclinical model for therapeutic interventions. However,
Bos, K van den, Leenen, P.J.M., Loenen, W.A.M., Löwenberg, B., Prins, A., Rooijen, N. van, Terpstra, W., Verstegen, M.M.A., Wagemaker, G., Wielenga, J.J., Wijngaardt, S. van, Wognum, A.W.   +11 more
core   +3 more sources