Results 1 to 10 of about 23,896 (206)

Mepolizumab Treatment in Patients with Severe Eosinophilic Asthma [PDF]

New England Journal of Medicine, 2014
Some patients with severe asthma have frequent exacerbations associated with persistent eosinophilic inflammation despite continuous treatment with high-dose inhaled glucocorticoids with or without oral glucocorticoids.In this randomized, double-blind, double-dummy study, we assigned 576 patients with recurrent asthma exacerbations and evidence of ...
Ortega, Hector G, Liu, Mark C, Pavord, Ian D, Brusselle, Guy G, Fitzgerald, J. Mark, Chetta, Alfredo, Humbert, Marc, Katz, Lynn E, Keene, Oliver N, Yancey, Steven W, Chanez, Pascal, CANONICA, GIORGIO   +11 more
openaire   +5 more sources

Severe asthma: adding new evidence – Latin American Thoracic Society

ERJ Open Research, 2021
This document constitutes a summary of the clinical practice guidelines (CPGs) prepared at the initiative of the Latin American Thoracic Society (ALAT). Due to new evidence in the treatment of severe asthma, it was agreed to select six clinical questions,
Gabriel García, Miguel Bergna, Juan C. Vásquez, Maria C. Cano Salas, José L. Miguel, Carlos Celis Preciado, Agustin Acuña Izcaray, Manuel Barros Monge, Natalia García Batista, Ignacio Zabert, José L. Mayorga, Renato Casanova Mendoza, Martha Gutierrez, Maria F. Montero Arias, Luzcenelia Urtecho Perez, Miguel Antúnez, Victoria Williams Derby, Alejandra Villatoro Azméquita, Luis Motiño, M. Alenita De Oliveira, Diana Rey Sanchez, Marisol Arroyo, Mario Rodriguez   +22 more
doaj   +1 more source

Successful treatment with dupilumab for mucus plugs in severe asthma

Respirology Case Reports, 2023
A 29‐year‐old man presented to our hospital with severe eosinophilic asthma. He needed a short OCS burst for exacerbation of asthma once every 1 or 2 months, although he used a high dose of inhaled corticosteroids and a long‐acting beta‐2 agonists. Chest
Moriyasu Anai, Chieko Yoshida, Hiroki Izumi, Kei Muramoto, Koichi Saruwatari, Yusuke Tomita, Hidenori Ichiyasu, Takuro Sakagami   +7 more
doaj   +1 more source

Personalized and Precision Medicine in Asthma and Eosinophilic Esophagitis: The Role of T2 Target Therapy

Pharmaceutics, 2023
The role of type 2 inflammation has been progressively associated with many diseases, including severe asthma, atopic dermatitis, nasal polyposis, eosinophilic granulomatosis with polyangiitis, and, recently, eosinophilic esophagitis.
Diego Bagnasco, Edoardo Vincenzo Savarino, Mona-Rita Yacoub, Fulvio Braido, Maria Giulia Candeliere, Edoardo Giannini, Giovanni Passalacqua, Elisa Marabotto   +7 more
doaj   +1 more source

Severe eosinophilic bronchial asthma: new therapeutic options

Медицинский совет, 2018
Eosinophilic asthma is a common phenotype of severe asthma, occurring in at least half of patients. In recent years, there have been significant changes in the approaches to the treatment of severe bronchial asthma and, above all, eosinophilic asthma ...
N. M. Nenasheva
doaj   +1 more source

Identification of distinct phenotypes related to benralizumab responsiveness in patients with severe eosinophilic asthma.

PLoS ONE, 2021
PurposeTo characterize the clinical phenotypes of severe eosinophilic asthma based on early responsiveness to benralizumab in terms of forced expiratory volume in 1 second (FEV1) improvement.Patients and methodsSixty-four participants diagnosed with ...
Hideyasu Yamada, Masayuki Nakajima, Masashi Matsuyama, Yuko Morishima, Naoki Arai, Norihito Hida, Taisuke Nakaizumi, Hironori Masuko, Yohei Yatagai, Takefumi Saito, Nobuyuki Hizawa   +10 more
doaj   +1 more source

Benralizumab in severe eosinophilic asthma

Signa Vitae

openalex   +2 more sources

Utility of serum periostin in combination with exhaled nitric oxide in the management of asthma

Allergology International, 2017
Type-2/eosinophilic inflammation plays a pivotal role in asthma. The identification of severe type-2/eosinophilic asthma is important for improving the management of patients with asthma.
Tadao Nagasaki, Hisako Matsumoto, Kenji Izuhara, Yoshihiro Kanemitsu, Yuji Tohda, Takahiko Horiguchi, Hideo Kita, Keisuke Tomii, Masaki Fujimura, Akihito Yokoyama, Yasutaka Nakano, Soichiro Hozawa, Isao Ito, Tsuyoshi Oguma, Yumi Izuhara, Tomoko Tajiri, Toshiyuki Iwata, Tetsuji Yokoyama, Akio Niimi, Michiaki Mishima   +19 more
doaj   +1 more source

Management of Severe Asthma in Eosinophilic Granulomatosis with Polyangiitis with Interleukin-5-Targeted Therapies: Current Status and Report of Two Cases

Applied Sciences, 2022
Eosinophilic granulomatosis with polyangiitis (EGPA) is a systemic disorder characterized by peripheral eosinophilia, severe eosinophilic asthma, sinusitis, transient pulmonary infiltrates, and features of medium/small-vessel vasculitis.
Ciro Romano, Domenico Cozzolino, Ausilia Sellitto, Luca Rinaldi   +3 more
doaj   +1 more source

Treating Acute Severe Eosinophilic Asthma with IL-5 Inhibitors in ICU

Case Reports in Pulmonology, 2022
Introduction. About 10% of the 300 million people worldwide who suffer from asthma have a severe disease that is uncontrolled despite treatment with inhaled corticosteroids and long-acting beta agonists.
Nicolas Barbarot, Emmanuelle Nourry, Nicolas Massart, François Legay, Matthieu Debarre, Pierre Fillatre, Eric Magalhaes, Arnaud Mari, Julien Wallois, Eric Briens, Stéphane Jouneau   +10 more
doaj   +1 more source