Results 141 to 150 of about 327,068 (394)

Stratification of eosinophilic asthma patients treated with reslizumab and GINA Step 4 or 5 therapy [PDF]

, 2017
Reslizumab, an anti-interleukin-5 monoclonal antibody, significantly reduces exacerbation frequency and improves lung function, asthma control and quality of life in adults with severe eosinophilic asthma, as demonstrated in Phase III studies.
Brusselle, Guy, Buhl, Roland, Canvin, Janice, Sun, Shawn X, Weiss, Sivan   +4 more
core   +3 more sources

Analysis of Differentially Expressed Proteins Involved in Shrimp and Crab Allergies

Journal of Clinical Laboratory Analysis, EarlyView.
Using proteomics techniques, we identified 90 differentially expressed proteins in children with shrimp and crab allergies compared to normal controls, with 82 upregulated and 8 downregulated proteins. Validation of MRC2 upregulation by ELISA in allergic patients highlights the potential role of this protein in the allergic response.
Ruhong Tan, Xiwen Wei, Jiacheng Zhong, Yuanbin Wang, Qing Yu   +4 more
wiley   +1 more source

Eosinophilic Asthma: Pathophysiology and Therapeutic Horizons

Cells
Asthma is a prevalent chronic non-communicable disease, affecting approximately 300 million people worldwide. It is characterized by significant airway inflammation, hyperresponsiveness, obstruction, and remodeling.
Musaddique Hussain, Gang Liu
doaj   +1 more source

Eosinophils Instance Object Segmentation on Whole Slide Imaging Using Multi-label Circle Representation [PDF]

arXiv, 2023
Eosinophilic esophagitis (EoE) is a chronic and relapsing disease characterized by esophageal inflammation. Symptoms of EoE include difficulty swallowing, food impaction, and chest pain which significantly impact the quality of life, resulting in nutritional impairments, social limitations, and psychological distress.
arxiv  

Indication‐Specific Dosing and Dose‐Evaluation Strategies in New Indications for Non‐Oncology Monoclonal Antibodies

The Journal of Clinical Pharmacology, EarlyView.
Abstract Compared to traditional small molecule drugs, monoclonal antibodies (mAbs) often display more complex pharmacokinetic (PK) and pharmacodynamic (PD) properties that may be impacted by disease‐specific factors. For mAbs in non‐oncology indications, where the same drug might be used for conditions involving different organ systems and/or having ...
Sherouk M. Tawfik, Fei Tang
wiley   +1 more source

Asthma control and sputum eosinophils in adult patients: a cross-sectional study in southern Brazil

Scientific Reports, 2023
Asthma control and health related quality of life are an important goal of asthma management, but their association with sputum eosinophilic inflammation has been less firmly established.
Vanessa Albano Barcellos, Vanessa Cristina Hartmann dos Santos, Maria Ângela Fontoura Moreira, Paulo de Tarso Roth Dalcin   +3 more
doaj   +1 more source

Severe bronchial asthma in children with exercise-induced bronchospasm [PDF]

, 2017
Based on a complex examination 46 of schoolchildren suffering from severe asthma, we established that greater proportion of schoolchildren with exercise-induced asthma was with symptoms of mucospin hypereosinophilia (average content of eosinophilic ...
Basіuk, N.V., Garas, M.N., Lekhkun, H.V., Lysenko, V.V.   +3 more
core  

A new formulation of oral viscous budesonide in treating of paediatric eosinophilic oesophagitis: a pilot study [PDF]

, 2017
OBJECTIVES: Oral viscous budesonide is a recent therapeutic option for eosinophilic oesophagitis (EoE) compared with dietary restriction and inhaled steroids.
Amil, D. J., Cucchiara, S., Isoldi, S., Lucarelli, S., Oliva, S., Papoff, P., Rossetti, D., Rossi, P., Tiberti, A.   +8 more
core   +1 more source

Oral Administration of Trichosanthes Kirilowii Fruit Extract Ameliorates Airway Inflammation and Suppresses Th2 Cell Activities in Ovalbumin‐Sensitized Mice

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Trichosanthes kirilowii is a plant used in traditional Chinese medicine. Its fruits, seeds, and roots can all be used medicinally. The fruit of T. kirilowii has a moistening effect on the lung for arresting cough. However, there is no scientific research to prove that the fruit of T. kirilowii can improve asthma. Herein, we evaluated whether T.
Ting‐Chi Lin, Wen‐Chung Huang, Chwan‐Fwu Lin, Wan‐Ting Chi, Shu‐Chen Cheng, Nai‐Chun Ting, Chian‐Jiun Liou   +6 more
wiley   +1 more source

Nasal Mucosa Regeneration After Reboot Surgery: Electron Microscopy and Histology Insights in CRSwNP

The Laryngoscope, EarlyView.
CRSwNP often requires multiple treatments, with monoclonal antibodies (mAbs) and endoscopic sinus surgeries used to manage resistant cases. This study focused on five patients undergoing reboot surgery, analyzing mucosal regeneration through biopsies and clinical outcomes over 24 months. It revealed complete non‐scarred regeneration of the nasal mucosa,
Francesca Pirola, Elena Vezzoli, Andrea Falqui, Francesco Giombi, Enrico Heffler, Giuseppe Mercante, Giuseppe Spriano, Fabio Grizzi, Luca Malvezzi   +8 more
wiley   +1 more source