Results 151 to 160 of about 93,898 (384)

Effectiveness of mepolizumab in patients with severe eosinophilic asthma: results from real-world clinical practice in Finland [PDF]

, 2022
Ville Koistinen, Paula Kauppi, J Idänpään-Heikkilä, Lauri Veijalainen, Ilona Iso‐Mustajärvi, Tero Ylisaukko‐oja, Juha Mehtälä, Arja Viinanen, Maritta Kilpeläinen   +8 more
openalex   +1 more source

Dupilumab and Systemic Hematologic Malignancies: Case Series and Literature Review

JEADV Clinical Practice, EarlyView.
ABSTRACT Background Atopic dermatitis (AD) is a chronic inflammatory skin disease affecting 15%–20% of children and 3%–10% of adults. An increased risk of systemic lymphomas – but not leukemias – has been reported in patients with AD. Dupilumab, a monoclonal IgG4 antibody targeting IL‐4 and IL‐13 signaling, is approved for moderate‐to‐severe AD and is ...
Nello Tommasino, Cataldo Patruno, Francesca di Vico, Maddalena Napolitano   +3 more
wiley   +1 more source

Recent Developments in Monoclonal-Antibody-Based Biologic Therapy for Severe Refractory Eosinophilic Asthma

Antibodies
Background: Asthma exhibits marked heterogeneity both clinically and at the molecular phenotypic level, requiring specifically targeted treatments to block the key pathways of the disease.
Garry M. Walsh
doaj   +1 more source

Using fractional exhaled nitric oxide (FeNO) to diagnose steroid-responsive disease and guide asthma management in routine care [PDF]

, 2013
Acknowledgements We thank Robin Taylor for his informative thinking and publications on FeNO, which have helped to influence and direct the thinking of the authors.
A Fuhlbrigge, A Zacharasiewicz, AD Smith, AD Smith, AD Smith, AF Gelb, American Thoracic Society / European Respiratory Society, C Delgado-Corcoran, CE Brightling, CE Brightling, D Lester, D Price, DE Shaw, DE Shaw, DN Payne, E Pizzichini, E Rosi, ED Bateman, ES Koster, G Stern, GL Piacentini, Global Initiative for Asthma, H Powell, HL Petsky, HL Petsky, I Horvath, ID Pavord, J Douwes, J Schilling, JF Donohue, JM Beck-Ripp, KW McGrath, L Grönke, L Wang, M Berry, MG Cochrane, MG Persson, MW Pijnenburg, N Pearce, NHLBI/WHO Workshop Report, P Haldar, P Haldar, RA Dweik, RA Robbins, RH Green, RH Green, RJ Green, RS Zeiger, SA Kharitonov, SJ Langley, ST Yavuz, TA Mahr, TL Frank, WJ Calhoun   +53 more
core   +1 more source

Mepolizumab, quality of life, and severe eosinophilic asthma [PDF]

The Lancet Respiratory Medicine, 2017
It is now ten years since the publication of the first clinical trial, eight years since the first key proof of concept studies in a population selected on the basis of inflammatory pattern and two years since approval of Mepolizumab as a treatment for severe eosinophilic asthma.
openaire   +3 more sources

Successful Treatment of Severe Adult Linear IgA Dermatosis Using Dupilumab

JEADV Clinical Practice, EarlyView.
ABSTRACT Linear IgA dermatosis (LAD) is a rare autoimmune subepidermal bullous dermatosis, characterised by the presence of erythematous vesiculobullous lesions arranged in rosettes or herpetiform clusters. The standard treatment involves the administration of dapsone, followed by sulfasalazine, and general corticosteroid therapy, often in combination ...
Célia Delesalle, Claire Abasq‐Thomas, Claire Bocciarelli, Amélie Bourhis, Marina Alexandre, Belen Eguia, Laurent Misery, Numa Deydier   +7 more
wiley   +1 more source

Combined biologic therapy targeting B cells and eosinophils in relapsing multiple sclerosis and severe asthma: a case report of ofatumumab and mepolizumab

Frontiers in Immunology
The management of multiple sclerosis (MS) in patients with significant comorbidities such as severe asthma presents unique therapeutic challenges. We report a case of successful combined biologic therapy with ofatumumab and mepolizumab in a patient with ...
Aurora Zanghì, Paola Sofia Di Filippo, Claudia Rutigliano, Carlo Avolio, Emanuele D’Amico   +4 more
doaj   +1 more source

Chronic rhinosinusitis with nasal polyps in older adults : clinical presentation, pathophysiology, and comorbidity

, 2019
Purpose of Review Chronic rhinosinusitis and nasal polyps (CRSwNP) is a common condition that significantly affects patients' life. This work aims to provide an up-to-date overview of CRSwNP in older adults, focusing on its aging-related clinical ...
Bachert, Claus, Lee, Ji-Hyang, Song, Woo-Jung, Won, Ha-Kyeong   +3 more
core   +2 more sources

Potential Biomarkers for Disease Stratification and Prognosis Prediction in Pediatric Asthma: LCN2, sST2 and FGF21

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Pediatric asthma is a common chronic airway inflammatory disease, where accurate assessment of disease severity and prognosis prediction is crucial for treatment decisions. Currently, there is a lack of precise and effective biomarkers.
Xu Yang, Hai Wang, Yong‐Zheng Zhang, Yan‐Yan Chen, Xin‐Xin Xing, Yi‐Cheng Ding   +5 more
wiley   +1 more source

Interleukin (IL)‐5, Eosinophils and IL‐5 Pathway Inhibitors in Eosinophilic Granulomatosis with Polyangiitis.

Arthritis &Rheumatology, Accepted Article.
Alvise Berti, Christian Pagnoux
wiley   +1 more source