Results 11 to 20 of about 23,896 (206)

Eosinophilic inflammation: An Appealing Target for Pharmacologic Treatments in Severe Asthma [PDF]

Biomedicines, 2022
Severe asthma is characterized by different endotypes driven by complex pathologic mechanisms. In most patients with both allergic and non-allergic asthma, predominant eosinophilic airway inflammation is present.
Alessandro Vatrella, Angelantonio Maglio, Corrado Pelaia, Luigi Ciampo, Giulia Pelaia, Carolina Vitale   +5 more
doaj   +2 more sources

Eosinophilic bioactivities in severe asthma [PDF]

World Allergy Organization Journal, 2016
Asthma is clearly related to airway or blood eosinophilia, and asthmatics with significant eosinophilia are at higher risk for more severe disease. Eosinophils actively contribute to innate and adaptive immune responses and inflammatory cascades through ...
Tara F. Carr, Sergejs Berdnikovs, Hans-Uwe Simon, Bruce S. Bochner, Lanny J. Rosenwasser   +4 more
doaj   +4 more sources

Primary care of asthma: new options for severe eosinophilic asthma [PDF]

Current Medical Research and Opinion, 2019
Objective: Asthma is a common heterogeneous disease characterized by airway inflammation and bronchoconstriction. Current treatment guidelines provide recommendations for categorizing disease severity, asthma control and management. This paper reviews asthma assessment in primary care and describes the pathophysiology, clinical characteristics and new ...
NEIL SKOLNIK, Sean P. Carnahan
openalex   +3 more sources

Efficacy of Benralizumab in Reducing FeNO in Severe Eosinophilic Asthma: The Role of CRSwNP [PDF]

Journal of Asthma and Allergy
Juan Luis Garcia-Rivero,1,2 Beatriz Abascal-Bolado,1 Nieves Aranda Sobrino,2 Cristina Ghadban Garrido2 1Respiratory Department, Marqués de Valdecilla University Hospital, Santander, Spain; 2Valdecilla Research Institute (IDIVAL), Santander ...
Garcia-Rivero JL, Abascal-Bolado B, Aranda Sobrino N, Ghadban Garrido C   +3 more
doaj   +2 more sources

Efficacy and safety of mepolizumab in severe eosinophilic asthma: a systematic review and meta-analysis. [PDF]

J Thorac Dis
Li Y, Li J, Yang H, Wu L.
europepmc   +2 more sources

Benralizumab, an add-on treatment for severe eosinophilic asthma: evaluation of exacerbations, emergency department visits, lung function, and oral corticosteroid use

Therapeutics and Clinical Risk Management, 2018
Diego Jose Maselli,1 Linda Rogers,2 Jay I Peters1 1Division of Pulmonary Diseases and Critical Care, University of Texas Health, San Antonio, TX, USA; 2Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine Mount Sinai &ndash ...
Maselli DJ, Rogers L, Peters JI
doaj   +3 more sources

Challenges With the Intolerance of Biologics in Severe Eosinophilic Asthma: The Risk of Exacerbations Is Time-Dependent With the Rise of Eosinophils. [PDF]

Cureus
Cortes-Telles A, Pou-Aguilar YN, Figueroa-Hurtado E, Vazquez-Lopez S, Ortiz DL.   +4 more
europepmc   +3 more sources

Construction of Severe Eosinophilic Asthma Related Competing Endogenous RNA Network by Weighted Gene Co-Expression Network Analysis

Frontiers in Pharmacology, 2022
Background: Currently, disease control in patients with severe eosinophilic asthma is not optimistic. Competing endogenous RNA (ceRNA) networks have been found to play a key role in asthma in recent years.
Haixia Wang, Zeyi Zhang, Yu Ma, Yuanmin Jia, Bin Ma, Junlian Gu, Ou Chen, Ou Chen, Shouwei Yue, Shouwei Yue   +9 more
doaj   +1 more source

Two years follow-up of relapsing eosinophilic pneumonia with concomitant severe asthma successfully treated with benralizumab: A case report and brief review of the literature

Respiratory Medicine Case Reports, 2023
Relapsing eosinophilic pneumonia and severe eosinophilic asthma are rare and disabling diseases, which share common inflammatory backgrounds and often require long-term systemic steroid therapy.
G. Angeletti, M. Mazzolini, A. Rocca
doaj   +1 more source

Severe Eosinophilic Asthma [PDF]

Journal of Clinical Medicine, 2019
Asthma is a heterogeneous disease with varying severity. Severe asthma is a subject of constant research because it greatly affects patients’ quality of life, and patients with severe asthma experience symptoms, exacerbations, and medication side effects.
Bakakos, A., Loukides, S., Bakakos, P.
openaire   +3 more sources