Results 251 to 260 of about 327,068 (394)

Additional file 2 of Efficacy of benralizumab for patients with severe eosinophilic asthma: a retrospective, real-life study

, 2020
Takanori Numata, Hanae Miyagawa, Saiko Nishioka, Keitaro Okuda, Hirofumi Utsumi, Mitsuo Hashimoto, Shunsuke Minagawa, Takeo Ishikawa, Hiromichi Hara, Jun Araya, Kazuyoshi Kuwano   +10 more
openalex   +2 more sources

Mepolizumab for severe eosinophilic asthma – A one-year real life Portuguese study

, 2021
Rita Brás, Marisa Paulino, Cláudia Varandas, C. Coutinho, Maria Silva, Rita Limão, Célia Costa, E. Alonso, Elisa Pedro, Ana Mendes   +9 more
openalex   +1 more source

Complementary Analysis of Local and Systemic Effects of Dupilumab in Paediatric AD Using Tape Strips and Serum

Clinical &Experimental Allergy, EarlyView.
ABSTRACT Objective This study investigates local and systemic immune‐related proteins in tape strips and serum of paediatric atopic dermatitis (AD) patients treated with dupilumab, and explores their correlation with clinical severity. Methods Twenty paediatric AD patients (< 18 years) starting dupilumab treatment were included.
Lisa P. van der Rijst, Edward F. Knol, Nicolaas P. A. Zuithoff, Constance F. den Hartog Jager, Femke van Wijk, Marjolein S. de Bruin‐Weller, Marlies de Graaf   +6 more
wiley   +1 more source

Advancing Remission in Severe Asthma With Benralizumab: Latest Findings, Current Perspectives and Future Direction

Clinical &Experimental Allergy, EarlyView.
ABSTRACT The introduction of biologics, such as benralizumab (an anti‐IL‐5 receptor α humanised monoclonal antibody), has made remission a feasible goal for patients with severe eosinophilic asthma (SEA). However, there are remaining research gaps and no clear consensus on the definition of remission.
Renaud Louis, Marek Lommatzsch, David J. Jackson, Andrew Menzies‐Gow, Anat Shavit, David Cohen, Flavia C. L. Hoyte, Stephanie Korn   +7 more
wiley   +1 more source

Severe Relapsing Eosinophilic Chronic Rhinosinusitis with Asthma Treated Consecutively with Inhaled Corticosteroids Exhaled through the Nose, Followed by Mepolizumab and Dupilumab

, 2021
Eriko Ogino, Hirotaka Yasuba
openalex   +2 more sources

Dupilumab and Blood Eosinophilia: A Disease‐Specific Phenomenon?

Allergy, EarlyView.
Andrea Portacci, Remo Poto, Gilda Varricchi, Giovanna Elisiana Carpagnano   +3 more
wiley   +1 more source

Deficiency of Aging‐Related Gene Chitinase‐Like 4 Impairs Olfactory Epithelium Homeostasis

Cell Proliferation, EarlyView.
Deficiency of Chil4 impairs OE homeostasis through loss of sustentacular cells and a specific type of immature sensory neuron, cell cycle arrest in globose basal cells, and inflammatory activation in microglia‐like cells. ABSTRACT Mammalian olfactory epithelium (OE) undergoes consistent self‐renewal throughout life.
Tingting Wu, Weihao Li, Liujing Zhuang, Jinxia Liu, Ping Wang, Ye Gu, Yongliang Liu, Yiqun Yu   +7 more
wiley   +1 more source

Pathogenic variants in chromatin‐related genes: Linking immune dysregulation to neuroregression and acute neuropsychiatric disorders

Developmental Medicine &Child Neurology, EarlyView.
Chromatin machinery influences how DNA is ‘wrapped’ around histones in the nucleosome of immune and brain cells. Plain language summary: https://onlinelibrary.wiley.com/doi/10.1111/dmcn.16299 Abstract We report eight children with de novo pathogenic DNA variants in chromatin‐related genes: MORC2, CHD7, KANSL1, KMT2D, ZMYND11, HIST1HIE, EP300, and KMT2B.
Russell C. Dale, Shekeeb Mohammad, Velda X. Han, Hiroya Nishida, Himanshu Goel, Stuart G. Tangye, Georgina Hollway, Esther Tantsis, Deepak Gill, Shrujna Patel, Chromatin Immune‐Brain Group, Michael Lonergan, Melanie Wong, Kavitha Kothur, Erica Tsang   +14 more
wiley   +1 more source

Efficacy and Safety of Mepolizumab in the Management of Severe Eosinophilic Asthma: A Systematic Review. [PDF]

Cureus, 2023
Dighriri IM, Alnughaythir AI, Albesisi AA, Alhuwaimel DI, Alotaibi AS, Alghowaidi LA, Almalki FH, Al-Bukhari JN, Alshammari TR, Alwathnani FH, Alghamdi AA, Alghamdi AA, Alshehri SD, Mahnashi NY, Abu Jamilah HA.   +14 more
europepmc   +1 more source

S119 Effect of tezepelumab in patients with severe, uncontrolled asthma by age of onset, allergic status, and eosinophilic phenotype [PDF]

, 2023
Mathur Sk, JL Hill, CS Ambrose, N. Martin, J-P Llanos, Nicolas Martin, Gene Colice   +6 more
openalex   +1 more source