Results 21 to 30 of about 23,896 (206)

Experience with mepolizumab in adults with severe eosinophilic asthma: a case series from India

Respirology Case Reports, 2021
Severe asthma can be associated with eosinophilic or allergic phenotypes or both. Eosinophilic inflammation is associated with exacerbations and disease severity due to biological activity of interleukin‐5 (IL‐5).
Venkata Nagarjuna Maturu, Priti Meshram, Soumya Das, Ashok Kumar Rajput, Arun Chowdary Kotaru, Bhavesh Kotak, Neeraj Markandeywar, Simran Chhatwal   +7 more
doaj   +1 more source

Biomarkers for severe eosinophilic asthma [PDF]

Journal of Allergy and Clinical Immunology, 2017
The last decade has seen the approval of several new biologics for the treatment of severe asthma-targeting specific endotypes and phenotypes. This review will examine how evidence generated from the mepolizumab clinical development program showed that blood eosinophil counts, rather than sputum or tissue eosinophil counts, evolved as a pharmacodynamic
Yancey, S, Keene, O, Albers, F, Ortega, H, Bates, S, Bleecker, E, Pavord, I   +6 more
openaire   +3 more sources

Identifying clinical and demographic characteristic differences between eosinophilic and non-eosinophilic asthma and detecting predictors of eosinophilic asthma among Egyptian asthmatic patients

The Egyptian Journal of Bronchology, 2022
Introduction Asthma is a heterogenous disease with various phenotypes that is characterized by airway limitation due to bronchospasm and airway inflammation associated with excessive mucus secretion.
Maged Mohamed Refaat, Riham Hazem Raafat, Heba Eid AbuAlia, Dina Sayed Sheha   +3 more
doaj   +1 more source

Neutrophils and Asthma

Diagnostics, 2022
Although eosinophilic inflammation is characteristic of asthma pathogenesis, neutrophilic inflammation is also marked, and eosinophils and neutrophils can coexist in some cases. Based on the proportion of sputum cell differentiation, asthma is classified
Akira Yamasaki, Ryota Okazaki, Tomoya Harada   +2 more
doaj   +1 more source

Severe eosinophilic asthma [PDF]

European respiratory journal, 2017
A task force has identified key consensus issues for defining, diagnosing and treating severe eosinophilic asthmahttp://ow.ly ...
Buhl, Roland, Humbert, Marc, Bjermer, Leif, Chanez, Pascal, Heaney, Liam G., Pavord, Ian, Quirce, Santiago, Virchow, Johann C., Holgate, Stephen, Djukanovic, Ratko, Chung, Kian Fan, Canonica, Walter, Papi, Alberto, Brightling, Chris, Horváth, Ildiko, Walker, Samantha, Brusselle, Guy, Backer, Vibeke, Kuna, Piotr, Bel, Elisabeth, De Llano, Luis Perez, Rabe, Klaus   +21 more
openaire   +5 more sources

PRevalence of the Eosinophilic Phenotype Among SeveRE asthma patients in Lebanon: results of the PREPARE study

Allergy, Asthma & Clinical Immunology, 2023
Background The prevalence of eosinophilic asthma in Lebanon, one of the most severe phenotypes among severe asthma, is not known. This study aimed at determining the prevalence of the eosinophilic phenotype defined as an eosinophil count ≥ 300 cells/mm3 ...
Wajdi Abi Saleh, Zuhair Alameh, Zeina Aoun Bacha, Joudy Bahous, Pierre Bou Khalil, Zahia Chahine, Hassan Chami, Georges Dabar, Hassan Dheiny, Alfred Dib, Dany farhat, Carla Irani, Georges Juvelekian, Nadim Kanj, Bassam Mansour, Moussa Riachi, Mirna Waked, Mohamad Yassine, Carole Youakim, Salah Zeinedine, Fares Zaitoun   +20 more
doaj   +1 more source

Effectiveness of Benralizumab in Improving the Quality of Life of Severe Eosinophilic Asthmatic Patients: Our Real-Life Experience

Frontiers in Pharmacology, 2021
Background: Severe eosinophilic asthma decreases lung function and causes worsen symptoms, often forcing recurrent maintenance corticosteroid use. The aim of our real-life study was to evaluate the effectiveness of an add-on treatment with benralizumab ...
Giulia Scioscia, Giulia Scioscia, Giovanna Elisiana Carpagnano, Carla Maria Irene Quarato, Carla Maria Irene Quarato, Donato Lacedonia, Donato Lacedonia, Sonia Santamaria, Sonia Santamaria, Piera Soccio, Annarita Depalo, Paolo Fuso, Paolo Fuso, Maria Pia Foschino Barbaro, Maria Pia Foschino Barbaro   +14 more
doaj   +1 more source

Effect of the Arg16Gly β₂-Adrenergic Receptor Polymorphism on Long-Term Mepolizumab Response and Clinical Remission in Severe Eosinophilic Asthma: A Genotype-Stratified, Multicenter Study. [PDF]

Allergy
Nolasco S, Fagone E, Campisi R, Portacci A, Scioscia G, Pelaia C, Maglio A, Candia C, Quaranta VN, Carrieri I, Saglia A, Vatrella A, Pelaia G, Vancheri C, Foschino Barbaro MP, D'Amato M, Carpagnano GE, Crimi N, Crimi C, Southern Italy Network on Severe Asthma Therapy.   +19 more
europepmc   +2 more sources

Targeting eosinophils: severe asthma and beyond [PDF]

Drugs in Context, 2019
Recent research in the field of bronchial asthma has mainly focused on eosinophilic disease phenotype. Several trials proved the efficacy and safety profile of eosinophils and interleukin (IL)-5 targeting molecules, currently approved for severe asthma and available on the market.
Caminati, Marco, Menzella, Francesco, Guidolin, Lucia, Senna, Gianenrico   +3 more
openaire   +5 more sources

Prevalence of eosinophilic, atopic, and overlap phenotypes among patients with severe asthma in Saudi Arabia: a cross-sectional study

BMC Pulmonary Medicine, 2022
Background Eosinophilia is a significant factor in asthma severity; however, the prevalence of severe eosinophilic asthma in Saudi Arabia is largely unknown.
Hamdan Al-Jahdali, Siraj Wali, Amr S. Albanna, Riyad Allehebi, Hussein Al-Matar, Mohamed Fattouh, Maarten Beekman   +6 more
doaj   +1 more source