Allergen-specific immunoglobulin E in sera of horses affected with insect bite hypersensitivity, severe equine asthma or both conditions [PDF]
Journal of Veterinary Internal Medicine, 2019 Maeva Verdon +2 more
exaly +2 more sources
Differential Expression of Serum MicroRNAs Supports CD4+ T Cell Differentiation into Th2/Th17 Cells in Severe Equine Asthma [PDF]
Genes, 2017 Alicja Pacholewska +2 more
exaly +2 more sources
Antigen array for serological diagnosis and novel allergen identification in severe equine asthma. [PDF]
Sci Rep, 2019 AbstractSevere equine asthma (sEA), which closely resembles human asthma, is a debilitating and performance-limiting allergic respiratory disorder which affects 14% of horses in the Northern Hemisphere and is associated with increased allergen-specific immunoglobulin E (IgE) against a range of environmental proteins. A comprehensive microarray platform
White SJ +7 more
europepmc +7 more sources
Giant Multinucleated Cells Are Associated with Mastocytic Inflammatory Signature Equine Asthma
Animals, 2022 Equine asthma is currently diagnosed by the presence of increased neutrophil (>5%), mast cell (>2%), and/or eosinophil (>1%) differential cell count. Macrophages are normal resident cells within the alveoli.
Ilaria Basano +7 more
doaj +1 more source
Animals, 2023 The relationship between helminth infection and allergic diseases has long intrigued the scientific community. This interaction was previously studied in a horse family with high incidence of severe equine asthma and in non-related severely asthmatic ...
Joana Simões +3 more
doaj +1 more source
Lung Function Variation during the Estrus Cycle of Mares Affected by Severe Asthma
Animals, 2022 While the prevalence of asthma is higher in boys than in girls during childhood, this tendency reverses at puberty, suggesting an effect of sex hormones on the disease pathophysiology.
Sophie Mainguy-Seers +2 more
doaj +1 more source
Some Genetic and Environmental Effects on Equine Asthma in Polish Konik Horses
Animals, 2021 Current knowledge of the genetic and environmental backgrounds of equine asthma seems to be insufficient, especially for primitive horse breeds. The main objectives of this study were to estimate the effects of sex, birth period, stud, parentage line and
Alicja Borowska +6 more
doaj +1 more source
Modulatory role of regulatory T cells in a murine model of severe equine asthma. [PDF]
BMC Vet Res, 2017 It is accepted that T regulatory cells (Treg) control different types of immune responses. In connection with this role, we have recently described an important increase in CD4+, CD25high, Foxp3+ lymphocytes in the airway system of horses coursing with an exacerbation of severe equine asthma (EA). To explore the potential role of this population in the
Henríquez C +6 more
europepmc +5 more sources
Severe asthma is associated with a remodeling of the pulmonary arteries in horses.
PLoS ONE, 2020 Pulmonary hypertension and cor pulmonale are complications of severe equine asthma, as a consequence of pulmonary hypoxic vasoconstriction. However, as pulmonary hypertension is only partially reversible by oxygen administration, other etiological ...
Serena Ceriotti +4 more
doaj +1 more source
Pulmonary vascular remodeling occurs in severe equine asthma.
, 2016 Severe equine asthma (heaves) is a chronic genetic-environmental condition characterized by airway neutrophilic inflammation leading to airway obstruction, lung tissue remodeling and hypoxemia (Bullone, 2015). Hypoxemia triggers pulmonary vasoconstriction, resulting in higher vascular resistance and development of pulmonary hypertension (PH).
S. Ceriotti +5 more
openaire +3 more sources