Neuroimmune Mechanisms in Equine Asthma: Primary Inflammatory Triggers, Neuroimmune Modulation and Chronic Airway Remodelling [PDF]
AnimalsEquine asthma is a chronic inflammatory disease of the lower respiratory tract, primarily associated with inhalation of organic dust, microbial particles and environmental aeroantigens.
Małgorzata Wierzbicka +2 more
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Modeling the pasture-associated severe equine asthma bronchoalveolar lavage fluid proteome identifies molecular events mediating neutrophilic airway inflammation [PDF]
Veterinary Medicine: Research and Reports, 2019 Lauren A Bright,1 Wellesley Dittmar,1 Bindu Nanduri,2 Fiona M McCarthy,3 Nisma Mujahid,2 Lais RR Costa,2 Shane C Burgess,3 Cyprianna E Swiderski11Department of Clinical Sciences, College of Veterinary Medicine, Mississippi State University, Starkville ...
Bright LA +7 more
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Alveolar macrophage phenotypes in severe equine asthma. [PDF]
Vet J, 2020 Because the alveolar macrophage (AM) phenotype of horses with severe equine asthma (SEA) is unknown, the cytokines expressed by M1- and M2-polarized AM were determined and the hypothesis that natural hay/straw challenge (NC) induces divergent AM phenotypes in control horses and horses with SEA was tested.
Wilson ME +3 more
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Inhaled ciclesonide is efficacious and well tolerated in the treatment of severe equine asthma in a large prospective European clinical trial. [PDF]
Equine Vet J, 2021 Pirie RS +4 more
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An Integrative miRNA-mRNA Expression Analysis Reveals Striking Transcriptomic Similarities between Severe Equine Asthma and Specific Asthma Endotypes in Humans. [PDF]
Genes (Basel), 2020 Severe equine asthma is an incurable obstructive respiratory condition affecting 10-15% of horses in temperate climates. Upon exposure to airborne antigens from hay feeding, affected horses show neutrophilic airway inflammation and bronchoconstriction ...
Hulliger MF +6 more
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Efficacy of tamoxifen for the treatment of severe equine asthma. [PDF]
J Vet Intern Med, 2018 Abstract Background Tamoxifen, a selective estrogen receptor modulator, decreased airway neutrophilia and improved clinical signs in an experimental model of equine asthma, and induced neutrophilic apoptosis in vitro.
Mainguy-Seers S, Picotte K, Lavoie JP.
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Bronchial brush cytology, endobronchial biopsy, and SALSA immunohistochemistry in severe equine asthma. [PDF]
Vet Pathol, 2022 Horses with severe equine asthma (SEA), also known as heaves and recurrent airway obstruction, have persistent neutrophilic inflammation of the lower airways. Cytologic evaluation of bronchoalveolar lavage (BAL) fluid is commonly used to confirm the clinical diagnosis of SEA.
Lee GKC +6 more
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Flow cytometric analysis of equine bronchoalveolar lavage fluid cells in horses with and without severe equine asthma. [PDF]
Vet Pathol, 2022 Severe equine asthma (SEA) is a common, debilitating lower airway inflammatory disorder of older horses. Alveolar macrophages (AMs) survey inhaled particulates from barn sources causing them to switch from an anti-inflammatory to a proinflammatory phenotype, resulting in neutrophil recruitment to the lung.
Kang H +6 more
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Steamed hay and alfalfa pellets for the management of severe equine asthma. [PDF]
Equine Vet JAbstract Background Steaming hay significantly reduces respirable particles and provides a palatable alternative to dry hay for horses with asthma, but there are few prospective studies demonstrating the clinical efficacy of steamed hay.
Symoens A +9 more
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Efficacy of inhaled budesonide for the treatment of severe equine asthma. [PDF]
Equine Vet J, 2019 Summary Background Corticosteroids are the most potent drugs for the control of severe equine asthma, but adverse effects limit their chronic systemic administration. Inhaled medications allow for drug delivery directly into the airways, reducing the harmful effects of these drugs.
Lavoie JP +7 more
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