Respiratory metabolites in bronchoalveolar lavage fluid (BALF) and exhaled breath condensate (EBC) can differentiate horses affected by severe equine asthma from healthy horses [PDF]
BMC Veterinary Research, 2020 Background The use of an untargeted metabolomic approach to investigate biofluids of respiratory origin is of increasing interest in human and veterinary lung research.
Marilena Bazzano +5 more
doaj +2 more sources
Neuroimmune Mechanisms in Equine Asthma: Primary Inflammatory Triggers, Neuroimmune Modulation and Chronic Airway Remodelling [PDF]
AnimalsEquine asthma is a chronic inflammatory disease of the lower respiratory tract, primarily associated with inhalation of organic dust, microbial particles and environmental aeroantigens.
Małgorzata Wierzbicka +2 more
doaj +2 more sources
Modeling the pasture-associated severe equine asthma bronchoalveolar lavage fluid proteome identifies molecular events mediating neutrophilic airway inflammation [PDF]
Veterinary Medicine: Research and Reports, 2019 Lauren A Bright,1 Wellesley Dittmar,1 Bindu Nanduri,2 Fiona M McCarthy,3 Nisma Mujahid,2 Lais RR Costa,2 Shane C Burgess,3 Cyprianna E Swiderski11Department of Clinical Sciences, College of Veterinary Medicine, Mississippi State University, Starkville ...
Bright LA +7 more
doaj +2 more sources
Alveolar macrophage phenotypes in severe equine asthma. [PDF]
Vet J, 2020 Because the alveolar macrophage (AM) phenotype of horses with severe equine asthma (SEA) is unknown, the cytokines expressed by M1- and M2-polarized AM were determined and the hypothesis that natural hay/straw challenge (NC) induces divergent AM phenotypes in control horses and horses with SEA was tested.
Wilson ME +3 more
europepmc +4 more sources
Inhaled ciclesonide is efficacious and well tolerated in the treatment of severe equine asthma in a large prospective European clinical trial [PDF]
Equine Veterinary Journal, 2021 Balazs Albrecht +2 more
exaly +2 more sources
Right ventricular function during acute exacerbation of severe equine asthma
Equine Veterinary Journal, 2017 Background: Pulmonary hypertension has been described in horses with severe equine asthma, but its effect on the right ventricle has not been fully elucidated.
Borowicz, H +11 more
core +4 more sources
An Integrative miRNA-mRNA Expression Analysis Reveals Striking Transcriptomic Similarities between Severe Equine Asthma and Specific Asthma Endotypes in Humans. [PDF]
Genes (Basel), 2020 Severe equine asthma is an incurable obstructive respiratory condition affecting 10-15% of horses in temperate climates. Upon exposure to airborne antigens from hay feeding, affected horses show neutrophilic airway inflammation and bronchoconstriction ...
Hulliger MF +6 more
europepmc +3 more sources
Efficacy of tamoxifen for the treatment of severe equine asthma. [PDF]
J Vet Intern Med, 2018 Abstract Background Tamoxifen, a selective estrogen receptor modulator, decreased airway neutrophilia and improved clinical signs in an experimental model of equine asthma, and induced neutrophilic apoptosis in vitro.
Mainguy-Seers S, Picotte K, Lavoie JP.
europepmc +4 more sources
Bronchial brush cytology, endobronchial biopsy, and SALSA immunohistochemistry in severe equine asthma. [PDF]
Vet Pathol, 2022 Horses with severe equine asthma (SEA), also known as heaves and recurrent airway obstruction, have persistent neutrophilic inflammation of the lower airways. Cytologic evaluation of bronchoalveolar lavage (BAL) fluid is commonly used to confirm the clinical diagnosis of SEA.
Lee GKC +6 more
europepmc +4 more sources
Flow cytometric analysis of equine bronchoalveolar lavage fluid cells in horses with and without severe equine asthma. [PDF]
Vet Pathol, 2022 Severe equine asthma (SEA) is a common, debilitating lower airway inflammatory disorder of older horses. Alveolar macrophages (AMs) survey inhaled particulates from barn sources causing them to switch from an anti-inflammatory to a proinflammatory phenotype, resulting in neutrophil recruitment to the lung.
Kang H +6 more
europepmc +4 more sources