Impaired response of the bronchial epithelium to inflammation characterizes severe equine asthma [PDF]
BMC Genomics, 2017 Background Severe equine asthma is a naturally occurring lung inflammatory disease of mature animals characterized by neutrophilic inflammation, bronchoconstriction, mucus hypersecretion and airway remodeling. Exacerbations are triggered by inhalation of
Laurence Tessier +6 more
doaj +9 more sources
Steamed hay for the prevention of severe equine asthma exacerbations. [PDF]
Equine Vet JAbstract Background Steaming hay reduces respirable particles and is commonly used to feed horses with asthma. However, it showed inconsistent benefits in clinical studies. Objectives (1) To assess the effects of steamed hay on lung function and airway inflammation in horses with severe equine asthma (SEA) in remission; (2) To compare these effects ...
Raïsky C +8 more
europepmc +4 more sources
Inhaled Corticosteroids Influence Pulmonary Microbiota in Severe Equine Asthma [PDF]
AnimalsThe use of inhaled corticosteroids (ICs) could influence the respiratory microbiota. In animals with asthma it is, however, difficult to separate the immunomodulatory effects of ICs from their indirect effects via improvement of ventilation.
Estelle Manguin +4 more
doaj +3 more sources
Sequence variant analysis of RNA sequences in severe equine asthma [PDF]
PeerJ, 2018 Background Severe equine asthma is a chronic inflammatory disease of the lung in horses similar to low-Th2 late-onset asthma in humans. This study aimed to determine the utility of RNA-Seq to call gene sequence variants, and to identify sequence variants
Laurence Tessier +2 more
doaj +6 more sources
Multi-Kingdom Fecal Microbiota Alterations in Horses with Severe Equine Asthma [PDF]
MicroorganismsSevere equine asthma (SEA) is a chronic inflammation of airways affecting ~14–20% of adult horses in the Northern Hemisphere. SEA is characterized by a mixed phenotype of T helper cell responses with marked neutrophilia in the bronchoalveolar lavage ...
Rafaela Santos +9 more
doaj +4 more sources
Fluticasone/salmeterol reduces remodelling and neutrophilic inflammation in severe equine asthma [PDF]
Scientific Reports, 2017 Asthmatic airways are inflamed and undergo remodelling. Inhaled corticosteroids and long-acting β2-agonist combinations are more effective than inhaled corticosteroid monotherapy in controlling disease exacerbations, but their effect on airway ...
Michela Bullone +4 more
doaj +6 more sources
eQTL discovery and their association with severe equine asthma in European Warmblood horses [PDF]
BMC Genomics, 2018 Background Severe equine asthma, also known as recurrent airway obstruction (RAO), is a debilitating, performance limiting, obstructive respiratory condition in horses that is phenotypically similar to human asthma.
Victor C. Mason +4 more
doaj +6 more sources
Heart rate variability in horses with and without severe equine asthma. [PDF]
Equine Vet JAbstract Background Equine asthma in severe form (severe equine asthma [sEA]) shares remarkable similarities with human asthma. Human studies detected changes in the autonomic nervous system function in asthmatic patients based on heart rate variability (HRV) analysis.
Nyerges-Bohák Z +5 more
europepmc +4 more sources
Differential Expression of Serum MicroRNAs Supports CD4⁺ T Cell Differentiation into Th2/Th17 Cells in Severe Equine Asthma. [PDF]
Genes (Basel), 2017 MicroRNAs (miRNAs) regulate post-transcriptional gene expression and may be exported from cells via exosomes or in partnership with RNA-binding proteins.
Pacholewska A +3 more
europepmc +5 more sources
Respiratory metabolites in bronchoalveolar lavage fluid (BALF) and exhaled breath condensate (EBC) can differentiate horses affected by severe equine asthma from healthy horses [PDF]
BMC Veterinary Research, 2020 Background The use of an untargeted metabolomic approach to investigate biofluids of respiratory origin is of increasing interest in human and veterinary lung research.
Marilena Bazzano +5 more
doaj +2 more sources