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Molecular basis of severe malaria [PDF]
Proceedings of the National Academy of Sciences, 2012 Malaria is an ancient scourge that continues to plague many regions of the developing world. Despite its long history, many aspects of the disease remain difficult to explain. For example, why some individuals experience relatively mild symptoms and others progress to severe and sometimes lethal disease is not understood. Similarly, the molecular basis
Kirk W. Deitsch, Chetan E. Chitnis
openaire +3 more sources
Antiprotozoal Activity of Highly Substituted Pyrazole and Pyrimidine Derivatives
ChemMedChem, EarlyView.Based on previously identified antimalarial agents, a series of highly substituted pyrazole and pyrimidines derivatives has been synthesized and tested for antiplasmodial and antileishmanial activity. Selected derivatives show promising antiplasmodial effect with a predicted favorable pharmacokinetic profile.
Matteo Lusardi +7 more
wiley +1 more source
Journal of Family Medicine and Primary Care, 2013 Background: Malaria threatens the life of under-five in rural Nigerian families. Although, factors that influence malaria in under-five are manifold. However, family biosocial factors may contribute to the variability of the clinical picture.
Gabriel Uche Pascal Iloh +3 more
doaj +1 more source
Malaria Journal, 2016 Glucose-6-phosphate dehydrogenase (G6PD) deficiency exhibits considerable allelic heterogeneity which manifests with variable biochemical and clinical penetrance.
Shivang S. Shah +10 more
semanticscholar +1 more source
Populations Addressed in Vaccines Approved via the European Medicines Agency
Clinical Pharmacology &Therapeutics, EarlyView.Therapeutic and prophylactic agents require robust evidence before patient use. Randomized controlled trials are essential for evaluating safety and efficacy but often exclude specific populations that are also targets for the intervention. This study assessed which populations are included in vaccine registration studies and/or addressed in label ...
Débora D. Gräf +3 more
wiley +1 more source
Severe Malaria in African Children - The Need for Continuing Investment.
New England Journal of Medicine, 2016 Today, 57% of Africans live in areas with moderate-to-high rates of malaria transmission, with 10 countries accounting for 87% of people exposed to the highest-intensity transmission. About 1200 children die from malaria in sub-Saharan Africa every day.
K. Maitland
semanticscholar +1 more source
Rethinking Chlorine: Essential Chemical or Replaceable Risk?
ChemSusChem, EarlyView.Chlorine is essential for the production of plastics and pharmaceuticals but poses significant safety and environmental risks. Herein, processes are presented that substitute chlorine or reduce its demand. Where indispensable, trichloride‐ and bichloride‐based ionic liquids could enhance safety and streamline the integration of renewable energy ...
Johannes Schwan +6 more
wiley +1 more source
, 2005 Artemisinins were discovered to be highly effective antimalarial drugs shortly after the isolation of the parent artemisinin in 1971 in China. These compounds combine potent, rapid antimalarial activity with a wide therapeutic index and an absence of ...
Haynes, RK, Krishna, S, Woodrow, CJ
core +2 more sources
A novel locus of resistance to severe malaria in a region of ancient balancing selection
Nature, 2015 The high prevalence of sickle haemoglobin in Africa shows that malaria has been a major force for human evolutionary selection, but surprisingly few other polymorphisms have been proven to confer resistance to malaria in large epidemiological studies. To
Gavin Kirk A. Chris C. A. Dominic P. Gavin Quang Geraldi Band Rockett Spencer Kwiatkowski Band Si Le Clarke +72 more
semanticscholar +1 more source
Clinical Infectious Diseases, 2020 Background The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) first broke out in Wuhan (China) and subsequently spread worldwide. Chloroquine has been sporadically used in treating SARS-CoV-2 infection.
Xueting Yao +14 more
semanticscholar +1 more source