Results 11 to 20 of about 235,554 (306)

Associations between erythrocyte polymorphisms and risks of uncomplicated and severe malaria in Ugandan children: A case control study. [PDF]

PLoS ONE, 2018
BACKGROUND:Evidence for association between sickle cell and alpha thalassemia trait and severe malaria is compelling. However, for these polymorphisms associations with uncomplicated malaria, and for G6PD deficiency associations with uncomplicated and ...
Arthur Mpimbaza, Andrew Walakira, Grace Ndeezi, Anne Katahoire, Charles Karamagi, Samuel L Nsobya, Stephen Tukwasibwe, Victor Asua, Philip J Rosenthal   +8 more
doaj   +1 more source

Artemether for severe malaria [PDF]

Cochrane Database of Systematic Reviews, 2014
In 2011 the World Health Organization (WHO) recommended parenteral artesunate in preference to quinine as first-line treatment for people with severe malaria. Prior to this recommendation, many countries, particularly in Africa, had begun to use artemether, an alternative artemisinin derivative.
Esu, Ekpereonne, Effa, Emmanuel E, Opie, Oko N, Uwaoma, Amirahobu, Meremikwu, Martin M   +4 more
openaire   +2 more sources

Affinity proteomics reveals elevated muscle proteins in plasma of children with cerebral malaria [PDF]

, 2014
Systemic inflammation and sequestration of parasitized erythrocytes are central processes in the pathophysiology of severe Plasmodium falciparum childhood malaria. However, it is still not understood why some children are more at risks to develop malaria
Afolabi, Nathaniel K., Ajetunmobi, Wasiu A., Akinbami, Felix O., Akinkunmi, Francis, Bachmann, Julie, Brown, Biobele J., Burte, Florence, Conte, Ianina, Fernandez-Reyes, Delmiro, Kampf, Caroline, Nilsson, Peter, Omokhodion, Samuel, Orimadegun, Adebola E., Pawitan, Yudi, Pramana, Setia, Schwenk, Jochen M., Shokunbi, Wuraola A., Sodeinde, Olugbemiro, Uhlen, Mathias, Wahlgren, Mats   +19 more
core   +3 more sources

Preclinical immunogenicity and safety of the cGMP-grade placental malaria vaccine PRIMVACResearch in context

EBioMedicine, 2019
Background: VAR2CSA is the lead antigen for developing a vaccine that would protect pregnant women against placental malaria. A multi-system feasibility study has identified E.
Arnaud Chêne, Stéphane Gangnard, Anna Guadall, Hervé Ginisty, Odile Leroy, Nicolas Havelange, Nicola K. Viebig, Benoît Gamain   +7 more
doaj   +1 more source

Assessment of severe malaria in a multicenter, phase III, RTS, S/AS01 malaria candidate vaccine trial: case definition, standardization of data collection and patient care. [PDF]

, 2011
BACKGROUND\ud \ud An effective malaria vaccine, deployed in conjunction with other malaria interventions, is likely to substantially reduce the malaria burden. Efficacy against severe malaria will be a key driver for decisions on implementation.
Amanda Leach, Brian Greenwood, Daniel Ansong, David Schellenberg, Jahit Sacarlal, Jennifer Evans, Johan Vekemans, Kevin Marsh, Kwaku Asante, Mary J Hamel, Nahya Salim, null null, Patricia Njuguna, Philip Bejon, Portia Kamthunzi, Samwel Gesase, Solange Soulanoudjingar, Walter Otieno, William Kabore   +18 more
core   +4 more sources

Artemether for severe malaria [PDF]

Cochrane Database of Systematic Reviews, 2019
In 2011 the World Health Organization (WHO) recommended parenteral artesunate in preference to quinine as first-line treatment for people with severe malaria. Prior to this recommendation many countries, particularly in Africa, had begun to use artemether, an alternative artemisinin derivative.
Esu, Ekpereonne B, Effa, Emmanuel E, Opie, Oko N, Meremikwu, Martin M   +3 more
openaire   +3 more sources

Malaria-filaria coinfection in mice makes malarial disease more severe unless filarial infection achieves patency [PDF]

, 2005
Coinfections are common in natural populations, and the literature suggests that helminth coinfection readily affects how the immune system manages malaria.
Allen, Judith E, Graham, Andrea L, Lamb, Tracey J, Read, Andrew F   +3 more
core   +3 more sources

Severe childhood malaria syndromes defined by plasma proteome profiles [PDF]

, 2012
BACKGROUND Cerebral malaria (CM) and severe malarial anemia (SMA) are the most serious life-threatening clinical syndromes of Plasmodium falciparum infection in childhood.
A Hodgetts, Adebola E. Orimadegun, AE Orimadegun, AK Rowe, AL Conroy, Barry K. Ely, Biobele J. Brown, C Wu, D Agranoff, Delmiro Fernandez-Reyes, Dimitrios Athanasakis, FE Lovegrove, Felix O. Akinbami, Florence Burté, Francesca Battaglia, Francis Akinkunmi, FX Wu, G Sandhu, J Amzat, J Bryce, K Marsh, Kevin KA. Tetteh, Kikelomo Osinusi, LK Erdman, MC Papadopoulos, Nathaniel K. Afolabi, Olayinka Kowobari, Olugbemiro Sodeinde, RT Pang, RW Snow, S Rojas-Galeano, Samuel Omokhodion, SI Hay, SI Hay, SJ Ceesay, Wasiu A. Ajetunmobi, Wuraola A. Shokunbi   +36 more
core   +3 more sources

Severe vivax malaria in Eastern India

Asian Journal of Medical Sciences, 2015
Background: Conventionally, vivax malaria was called as benign malaria. But recent reports of severe vivax malaria were coming from different parts of the World.
Joydeep Mukherjee
doaj   +1 more source

Diagnosing Severe Falciparum Malaria in Parasitaemic African Children: A Prospective Evaluation of Plasma PfHRP2 Measurement. [PDF]

, 2012
In African children, distinguishing severe falciparum malaria from other severe febrile illnesses with coincidental Plasmodium falciparum parasitaemia is a major challenge. P. falciparum histidine-rich protein 2 (PfHRP2) is released by mature sequestered
Amos, Ben, Chotivanich, Kesinee, Day, Nicholas P J, Dondorp, Arjen M, Fanello, Caterina I, Gesase, Samwel, Gomes, Ermelinda, Hendriksen, Ilse C E, Joseph, Sarah, Karema, Corine, Lee, Sue J, Maitland, Kathryn, Mtove, George, Mwanga-Amumpaire, Juliet, Olaosebikan, Rasaq, Pan-Ngum, Wirichada, Reyburn, Hugh, Saiwaew, Somporn, Silamut, Kamolrat, Tshefu, Antoinette K, von Seidlein, Lorenz, White, Lisa J, White, Nicholas J, Woodrow, Charles   +23 more
core   +5 more sources