Results 11 to 20 of about 110,606 (268)

Severe vivax malaria: Newly recognised or rediscovered? [PDF]

open access: yes, 2008
Stephen Rogerson and Richard Carter discuss two new studies that challenge current dogma by suggesting that vivax malaria can cause severe ...
Carter Richard   +7 more
core   +1 more source

Preclinical immunogenicity and safety of the cGMP-grade placental malaria vaccine PRIMVACResearch in context

open access: yesEBioMedicine, 2019
Background: VAR2CSA is the lead antigen for developing a vaccine that would protect pregnant women against placental malaria. A multi-system feasibility study has identified E.
Arnaud Chêne   +7 more
doaj   +1 more source

Severe falciparum malaria in Gabonese children: clinical and laboratory features. [PDF]

open access: yes, 2005
BACKGROUND: Malaria continues to claim one to two million lives a year, mainly those of children in sub-Saharan Africa. Reduction in mortality depends, in part, on improving the quality of hospital care, the training of healthcare workers and ...
Mboza, Béatrice   +51 more
core   +1 more source

Candidate human genetic polymorphisms and severe malaria in a Tanzanian population. [PDF]

open access: yes, 2012
Human genetic background strongly influences susceptibility to malaria infection and progression to severe disease and death. Classical genetic studies identified haemoglobinopathies and erythrocyte-associated polymorphisms, as protective against severe ...
Riley, Eleanor M   +56 more
core   +1 more source

Assessment of severe malaria in a multicenter, phase III, RTS, S/AS01 malaria candidate vaccine trial: case definition, standardization of data collection and patient care. [PDF]

open access: yes, 2011
BACKGROUND\ud \ud An effective malaria vaccine, deployed in conjunction with other malaria interventions, is likely to substantially reduce the malaria burden. Efficacy against severe malaria will be a key driver for decisions on implementation.
Amanda Leach   +56 more
core   +1 more source

Severe vivax malaria in Eastern India

open access: yesAsian Journal of Medical Sciences, 2015
Background: Conventionally, vivax malaria was called as benign malaria. But recent reports of severe vivax malaria were coming from different parts of the World.
Joydeep Mukherjee
doaj   +1 more source

Age patterns of severe paediatric malaria and their relationship to Plasmodium falciparum transmission intensity. [PDF]

open access: yes, 2009
BACKGROUND: The understanding of the epidemiology of severe malaria in African children remains incomplete across the spectrum of Plasmodium falciparum transmission intensities through which communities might expect to transition, as intervention ...
Abdullah Al-Taiar   +25 more
core   +1 more source

Candidate polymorphisms and severe malaria in a Malian population. [PDF]

open access: yes, 2012
Malaria is a major health burden in sub-Saharan African countries, including Mali. The disease is complex, with multiple genetic determinants influencing the observed variation in response to infection, progression, and severity.
Belco Poudiougou   +56 more
core   +1 more source

Improving statistical power in severe malaria genetic association studies by augmenting phenotypic precision

open access: yeseLife, 2021
Severe falciparum malaria has substantially affected human evolution. Genetic association studies of patients with clinically defined severe malaria and matched population controls have helped characterise human genetic susceptibility to severe malaria ...
James A Watson   +20 more
doaj   +1 more source

Gradual acquisition of immunity to severe malaria with increasing exposure. [PDF]

open access: yes, 2014
Previous analyses have suggested that immunity to non-cerebral severe malaria due to Plasmodium falciparum is acquired after only a few infections, whereas longitudinal studies show that some children experience multiple episodes of severe disease ...
Drakeley, Chris J   +22 more
core   +1 more source

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