Results 21 to 30 of about 1,804,243 (315)

Improving statistical power in severe malaria genetic association studies by augmenting phenotypic precision

open access: yeseLife, 2021
Severe falciparum malaria has substantially affected human evolution. Genetic association studies of patients with clinically defined severe malaria and matched population controls have helped characterise human genetic susceptibility to severe malaria ...
James A Watson   +20 more
doaj   +1 more source

Age patterns of severe paediatric malaria and their relationship to Plasmodium falciparum transmission intensity. [PDF]

open access: yes, 2009
BACKGROUND: The understanding of the epidemiology of severe malaria in African children remains incomplete across the spectrum of Plasmodium falciparum transmission intensities through which communities might expect to transition, as intervention ...
Abdullah Al-Taiar   +25 more
core   +1 more source

Candidate polymorphisms and severe malaria in a Malian population. [PDF]

open access: yes, 2012
Malaria is a major health burden in sub-Saharan African countries, including Mali. The disease is complex, with multiple genetic determinants influencing the observed variation in response to infection, progression, and severity.
Belco Poudiougou   +56 more
core   +2 more sources

Pathology of Severe Malaria

open access: yesPathogens, 2023
Malaria, a devastating disease transmitted by mosquitoes, continues to plague many regions worldwide, affecting millions of lives annually [...]
openaire   +3 more sources

Increased interferon-γ levels and risk of severe malaria: a meta-analysis

open access: yesScientific Reports, 2022
Interferon (IFN)-γ contributes to the pathogenesis of severe malaria; however, its mechanism remains unclear. Herein, differences in IFN-γ levels between patients with severe and uncomplicated malaria were evaluated using qualitative and quantitative ...
Aongart Mahittikorn   +5 more
doaj   +1 more source

Diagnosing Severe Falciparum Malaria in Parasitaemic African Children: A Prospective Evaluation of Plasma PfHRP2 Measurement. [PDF]

open access: yes, 2012
In African children, distinguishing severe falciparum malaria from other severe febrile illnesses with coincidental Plasmodium falciparum parasitaemia is a major challenge. P. falciparum histidine-rich protein 2 (PfHRP2) is released by mature sequestered
Pan-Ngum Wirichada   +127 more
core   +1 more source

The treatment of severe malaria

open access: yesTransactions of the Royal Society of Tropical Medicine and Hygiene, 2007
In the SEAQUAMAT trial, parenteral artesunate was shown to be associated with a considerably lower mortality than quinine, and is now the recommended treatment for severe malaria in low-transmission areas and in the second and third trimesters of pregnancy. A trial is underway to establish its role in African children.
Dondorp, A, Day, N
openaire   +3 more sources

Severe malaria - a case of fatal Plasmodium knowlesi infection with post-mortem findings: a case report. [PDF]

open access: yes, 2010
BACKGROUND: Zoonotic malaria caused by Plasmodium knowlesi is an important, but newly recognized, human pathogen. For the first time, post-mortem findings from a fatal case of knowlesi malaria are reported here.
Hiu, Jessie   +65 more
core   +1 more source

Preparedness for severe malaria

open access: yesTidsskrift for Den norske legeforening, 2015
About 60 patients with malaria are admitted to Norwegian hospitals every year. The prescription figures for malaria medication may suggest that Norwegians are increasingly exposed to malaria infection.All Norwegian hospitals with a department of internal medicine were sent an electronic questionnaire for reporting the available methods for diagnosing ...
Åsmund, Heggheim   +2 more
openaire   +2 more sources

Determining the severity of Plasmodium falciparum malaria in Ethiopia

open access: yesJournal of Infection and Public Health, 2013
Summary: Background: In the majority of health centers in Ethiopia, the severity of falciparum malaria has been determined by parasitemia alone. However, it has been suggested that the use of peripheral infected RBC counts as an indicator of disease ...
Zinaye Tekeste   +2 more
doaj   +1 more source

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