miR-424 inhibits apoptosis and inflammatory responses induced by sevoflurane through TLR4/MyD88/NF-κB pathway [PDF]
BMC Anesthesiology, 2022 Background Side effects of sevoflurane in anterograde and retrograde memory have been widely reported. However, there is no convincing evidence that sevoflurane directly causes the development of neurotoxicity.
Zeyu Li, Tao Wang, Yonghao Yu
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Correction to “Failure to Protect Against Myocardial Ischemia‐Reperfusion Injury With Sevoflurane Postcondioning in Old Rats In Vivo” [PDF]
Acta Anaesthesiol ScandActa Anaesthesiologica Scandinavica, Volume 70, Issue 3, March 2026.
wiley +2 more sources
Increased Orexin by High Concentration of Sevoflurane Enhances the Suprahyoid Muscle Activity Involves in Gasping‐Like Respiration of Mice [PDF]
FASEB BioAdvances, Volume 8, Issue 1, January 2026.ABSTRACT Gasping respiration enhances survival chances during cardiac arrest by activating the suprahyoid muscles (SHMs), which are crucial for airway dilation. We previously reported that the high concentration of sevoflurane (6.5%: 2.0 minimum alveolar concentration, MAC) leads to gasping‐like respiration in mice.
Yoko Irukayama‐Tomobe +14 more
wiley +2 more sources
ATF5‐Dependent GDF15 Expression Mediates Anesthesia‐Induced Neuroprotection Against Stroke [PDF]
Advanced Science, Volume 13, Issue 3, 14 January 2026.Anesthesia‐induced preconditioning protects against perioperative stroke. By manipulating ATF5 in excitatory neurons, it is shown that anesthesia‐driven ATF5 upregulation activates the mitochondrial unfolded protein response (UPRmt) and elevates GDF15 expression.
Xianshu Ju +11 more
wiley +2 more sources
Sevoflurane Inhibits Layer 5 Pyramidal Neurons via Kv1.2‐Dependent Modulation of Subthreshold Currents [PDF]
Journal of Neurochemistry, Volume 170, Issue 1, January 2026.General anesthetics suppress cortical activity, but their cellular mechanisms remain unclear. We investigated how the volatile anesthetic sevoflurane affects layer 5 pyramidal neurons in the auditory cortex. Using patch‐clamp recordings and computational modeling, we found that low‐dose sevoflurane reduces neuronal firing through Kv1.2 channel ...
Aelton S. Araujo +4 more
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Effect of a Professional Information Campaign on the Use of Sevoflurane in Pediatric Anesthesia [PDF]
Paediatr AnaesthPediatric Anesthesia, Volume 36, Issue 2, Page 215-217, February 2026.
Lionel Bouvet +3 more
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Electroacupuncture Pretreatment Ameliorates Perioperative Neurocognitive Disorder in Aged Mice by Inhibiting Ferroptosis Through the SIRT1/NRF2/GPX4 Pathway [PDF]
Journal of Cellular and Molecular Medicine, Volume 30, Issue 1, January 2026.ABSTRACT Perioperative neurocognitive disorder (PND) is a common complication after anesthesia surgery in elderly patients, which not only reduces the patients' quality of life but also increases the burden on their families and society. PND has been found to be closely related to ferroptosis. This study investigated whether electroacupuncture (EA) can
Zhongying Du +6 more
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F1000Research, 2015 Sevoflurane has been available for clinical practice for about 20 years. Nowadays, its pharmacodynamic and pharmacokinetic properties together with its absence of major adverse side effects on the different organ systems have made this drug accepted worldwide as a safe and reliable anesthetic agent for clinical practice in various settings.
Stefan De Hert, Anneliese Moerman
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Chinese Journal of Physiology, 2023 Anesthetics exposure induces neurocognitive deficits during brain development and impairs self-renewal and differentiation of neural stem cells (NSCs).
Minmin Cai, Xiang Gao, Shenghui Yu
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Frontiers in Medicine, 2022 Multiple sevoflurane exposure may result in cognitive deficits in neonatal animals. This study attempted to investigate the potential mechanism of sevoflurane-induced neurotoxicity in developing hippocampus.
Piao Zhang +3 more
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