Results 11 to 20 of about 82,704 (334)

Mitochondria-Related Ferroptosis Drives Cognitive Deficits in Neonatal Mice Following Sevoflurane Administration

Frontiers in Medicine, 2022
Multiple sevoflurane exposure may result in cognitive deficits in neonatal animals. This study attempted to investigate the potential mechanism of sevoflurane-induced neurotoxicity in developing hippocampus.
Piao Zhang, Yeru Chen, ShuXia Zhang, Gang Chen   +3 more
doaj   +2 more sources

Dexmedetomidine Attenuates Neurotoxicity in Developing Rats Induced by Sevoflurane through Upregulating BDNF-TrkB-CREB and Downregulating ProBDNF-P75NRT-RhoA Signaling Pathway

Mediators of Inflammation, 2020
To investigate the mechanism dexmedetomidine in relieving the neurotoxicity of a developing brain induced by sevoflurane. Sprague-Dawley rats, 6 days old, were randomly divided into three groups.
Yunxia Dong, Wei Hong, Zhiyin Tang, Yan Gao, Xiuying Wu, Hongtao Liu   +5 more
doaj   +2 more sources

Sevoflurane inhibits the progression of ovarian cancer through down-regulating stanniocalcin 1 (STC1)

Cancer Cell International, 2019
Background Ovarian cancer is one of the leading causes of female death worldwide, with a poor prognosis of advanced patients. Sevoflurane, a volatile anesthetic commonly used in clinical operations, has been reported to have anti-cancer activity against ...
Chuanfeng Zhang, Baosheng Wang, Xiuqin Wang, Xiugui Sheng, Yongchun Cui   +4 more
doaj   +2 more sources

Sevoflurane Exposure Induces Neuronal Cell Parthanatos Initiated by DNA Damage in the Developing Brain via an Increase of Intracellular Reactive Oxygen Species

Frontiers in Cellular Neuroscience, 2020
The safety of volatile anesthetics in infants and young children has been drawing increasing concern due to its potential neurotoxicity in the developing brain. Neuronal death is considered a major factor associated with developmental neurotoxicity after
Meihua Piao, Yingying Wang, Nan Liu, Xuedong Wang, Rui Chen, Jing Qin, Pengfei Ge, Chunsheng Feng   +7 more
doaj   +2 more sources

Sevoflurane Inhibits Proliferation and Invasion of Human Ovarian Cancer Cells by Regulating JNK and p38 MAPK Signaling Pathway

Drug Design, Development and Therapy, 2019
Kai Kang, Yue Wang Department of Anesthesiology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, People’s Republic of ChinaCorrespondence: Yue WangDepartment of Anesthesiology, Beijing Obstetrics and ...
Kang K, Wang Y
doaj   +2 more sources

Sevoflurane Aggravates the Progress of Alzheimer’s Disease Through NLRP3/Caspase-1/Gasdermin D Pathway

Frontiers in Cell and Developmental Biology, 2022
Background: Alzheimer’s disease (AD) is the most common form of dementia worldwide. Previous studies have reported that sevoflurane, a frequently used anesthetic, can induce cognitive impairment in preclinical and clinical settings.
Dingyuan Tian, Yanmei Xing, Wenli Gao, Hongyan Zhang, Yifeng Song, Ya Tian, Zhongliang Dai   +6 more
semanticscholar   +1 more source

Tripartite motif 72 inhibits apoptosis and mitochondrial dysfunction in neural stem cells induced by anesthetic sevoflurane by activating PI3K/AKT pathway

Chinese Journal of Physiology, 2023
Anesthetics exposure induces neurocognitive deficits during brain development and impairs self-renewal and differentiation of neural stem cells (NSCs).
Minmin Cai, Xiang Gao, Shenghui Yu
doaj   +1 more source

Update on the Mechanism and Treatment of Sevoflurane-Induced Postoperative Cognitive Dysfunction

Frontiers in Aging Neuroscience, 2021
Sevoflurane is one of the most widely used anesthetics for the induction and maintenance of general anesthesia in surgical patients. Sevoflurane treatment may increase the incidence of postoperative cognitive dysfunction (POCD), and patients with POCD ...
Cong Wang, Wei-can Chen, Yan Zhang, Shu Lin, He-fan He   +4 more
semanticscholar   +1 more source

Mechanistic insight into sevoflurane-associated developmental neurotoxicity

Cell Biology and Toxicology, 2021
With the development of technology, more infants receive general anesthesia for surgery, other interventions, or clinical examination at an early stage after birth.
Mingyang Sun, Zhongcong Xie, Jiaqiang Zhang, Y. Leng   +3 more
semanticscholar   +1 more source

The anesthetic sevoflurane induces tau trafficking from neurons to microglia

Communications Biology, 2021
Accumulation and spread of tau in Alzheimer’s disease and other tauopathies occur in a prion-like manner. However, the mechanisms and downstream consequences of tau trafficking remain largely unknown.
Yuanlin Dong, Feng Liang, Lining Huang, F. Fang, Guang Yang, R. Tanzi, Yiying Zhang, Qimin Quan, Zhongcong Xie   +8 more
semanticscholar   +1 more source