Results 21 to 30 of about 57,547 (259)

Mitophagy impairment is involved in sevoflurane-induced cognitive dysfunction in aged rats

Aging, 2020
Postoperative cognitive dysfunction (POCD) is frequently observed in elderly patients following anesthesia, but its pathophysiological mechanisms have not been fully elucidated.
Yeru Chen, Piao Zhang, Xianyi Lin, Huan-yi Zhang, Jiamin Miao, You-fa Zhou, Gang Chen   +6 more
semanticscholar   +1 more source

Resveratrol Mitigates Sevoflurane-Induced Neurotoxicity by the SIRT1-Dependent Regulation of BDNF Expression in Developing Mice

Oxidative Medicine and Cellular Longevity, 2020
Various lines of evidence suggest that neonatal exposure to general anesthetics, especially repeatedly, results in neuropathological brain changes and long-term cognitive impairment.
Xiaole Tang, Yilin Zhao, Zhi-qiang Zhou, Jing Yan, Biyun Zhou, Xiaohui Chi, A. Luo, Shiyong Li   +7 more
semanticscholar   +1 more source

Sevoflurane suppresses cell viability and invasion and promotes cell apoptosis in colon cancer by modulating exosome-mediated circ-HMGCS1 via the miR-34a-5p/SGPP1 axis

Oncology Report, 2020
As a novel halogenated hydroxyl ether-inhaled general anesthetic, sevoflurane has been reported to affect the progression of diverse human cancers. In the present study, we aimed to explore the functions and underlying mechanisms of sevoflurane in colon ...
Juan He, Huaping Zhao, Xing Liu, Dongmei Wang, Yong Wang, Yanqiu Ai, Jianjun Yang   +6 more
semanticscholar   +1 more source

Dexmedetomidine and Clonidine Attenuate Sevoflurane-Induced Tau Phosphorylation and Cognitive Impairment in Young Mice via α-2 Adrenergic Receptor.

Anesthesia and Analgesia, 2020
BACKGROUND Anesthetic sevoflurane induces tau phosphorylation and cognitive impairment in young mice. The underlying mechanism and the targeted interventions remain largely unexplored.
Mingyang Sun, Yuanlin Dong, Mengzhu Li, Yiying Zhang, Feng Liang, Iaqiang Zhang, S. Soriano, Zhongcong Xie   +7 more
semanticscholar   +1 more source

mtDNA-cGAS-STING axis-dependent NLRP3 inflammasome activation contributes to postoperative cognitive dysfunction induced by sevoflurane in mice

International Journal on Biological Sciences
The activation of NLRP3 inflammasome in microglia is critical for neuroinflammation during postoperative cognitive dysfunction (POCD) induced by sevoflurane.
Nan-Shi-Yu Yang, W. Zhong, Han-Xi Sha, Chen-Yu Zhang, Ling Jin, J. Duan, Jian-Bing Xiong, Zhi-Jian You, Yong Zhou, C. Guan   +9 more
semanticscholar   +1 more source

The effect of propofol and sevoflurane on cancer cell, natural killer cell, and cytotoxic T lymphocyte function in patients undergoing breast cancer surgery: an in vitro analysis

BMC Cancer, 2018
To clarify the effect of anaesthetic agents on cancer immunity, we evaluated the effects of propofol and sevoflurane on natural killer (NK) cell, cytotoxic T lymphocyte (CTL) counts and apoptosis rate in breast cancer and immune cells co-cultures from ...
Jeong-Ae Lim, Chung-Sik Oh, T. Yoon, Ji Yeon Lee, Seung-Hyun Lee, Y. Yoo, Jung-Hyun Yang, Seong-Hyop Kim   +7 more
semanticscholar   +1 more source

Dexmedetomidine Attenuates Neurotoxicity in Developing Rats Induced by Sevoflurane through Upregulating BDNF-TrkB-CREB and Downregulating ProBDNF-P75NRT-RhoA Signaling Pathway

Mediators of Inflammation, 2020
To investigate the mechanism dexmedetomidine in relieving the neurotoxicity of a developing brain induced by sevoflurane. Sprague-Dawley rats, 6 days old, were randomly divided into three groups.
Yunxia Dong, W. Hong, Zhiyin Tang, Yan Gao, Xiu-ying Wu, Hongtao Liu   +5 more
semanticscholar   +1 more source

A clinical review of inhalation anesthesia with sevoflurane: from early research to emerging topics

Journal of Anesthesia, 2017
A large number of studies during the past two decades have demonstrated the efficacy and safety of sevoflurane across patient populations. Clinical researchers have also investigated the effects of sevoflurane, its hemodynamic characteristics, its ...
J. Brioni, Shane Varughese, R. Ahmed, B. Bein   +3 more
semanticscholar   +1 more source

Sevoflurane Exposure Induces Neuronal Cell Parthanatos Initiated by DNA Damage in the Developing Brain via an Increase of Intracellular Reactive Oxygen Species

Frontiers in Cellular Neuroscience, 2020
The safety of volatile anesthetics in infants and young children has been drawing increasing concern due to its potential neurotoxicity in the developing brain. Neuronal death is considered a major factor associated with developmental neurotoxicity after
M. Piao, Yingying Wang, Nan Liu, Xuedong Wang, Rui Chen, J. Qin, Pengfei Ge, Chunsheng Feng   +7 more
semanticscholar   +1 more source

Respiratory Effects of Sevoflurane

Survey of Anesthesiology, 1987
The respiratory effects of sevoflurane were studied in seven patients and compared with values obtained in another seven patients anesthetized with halothane. Resting ventilation, resting PaCO2, and ventilatory response to CO2 were measured awake and at 1.1 and 1.4 MAC levels of both anesthetic agents.
Kazuyuki Ikeda, Matsuyuki Doi
openaire   +4 more sources