Results 21 to 30 of about 58,127 (276)

Direct and specific effect of sevoflurane anesthesia on rat Per2 expression in the suprachiasmatic nucleus. [PDF]

PLoS ONE, 2013
BACKGROUND: Our previous studies revealed that application of the inhalation anesthetic, sevoflurane, reversibly repressed the expression of Per2 in the mouse suprachiasmatic nucleus (SCN). We aimed to examine whether sevoflurane directly affects the SCN.
Megumi Anzai, Norio Iijima, Shimpei Higo, Ken Takumi, Izumi Matsuo, Keisuke Mori, Yumiko Ohe, Kana Kadota, Toshio Akimoto, Atsuhiro Sakamoto, Hitoshi Ozawa   +10 more
doaj   +1 more source

The Effect of Sevoflurane Plus Propofol on Pain and Complications after Laminectomy: A Randomized Double Blind Clinical Trial [PDF]

Journal of Clinical and Diagnostic Research, 2017
Introduction: Pain is one of the most important reasons for the patients concern after surgery. The perfect sedative should have properties like rapid onset, least pain and adverse effects.
Aminolah Vasigh, Fatemeh Najafi, Molouk Jaafarpour, Javaher Khajavikhan, Ali Khani   +4 more
doaj   +1 more source

The effects of midazolam and sevoflurane on the GABA receptors with alternatively spliced variants of the γ2 subunit [PDF]

Korean Journal of Anesthesiology, 2011
BackgroundEmergence agitation after sevoflurane anesthesia in children can be prevented by midazolam. Alternative splicing of the GABAA receptor changes with age.
Woosik Eom, Jung Min Lee, Jeongmi Park, Kyungho Choi, Sung-Jun Jung, Hee-Soo Kim   +5 more
doaj   +1 more source

Tau Contributes to Sevoflurane-induced Neurocognitive Impairment in Neonatal Mice

Anesthesiology, 2020
Background: Sevoflurane anesthesia induces Tau phosphorylation and cognitive impairment in neonatal but not in adult mice. This study tested the hypothesis that differences in brain Tau amounts and in the activity of mitochondria–adenosine triphosphate ...
Yang Yu, Yongya Yang, Hong Tan, M. Boukhali, A. Khatri, Yong-Hao Yu, Fuzhou Hua, Ling Liu, Mengzhu Li, Guang Yang, Yuanlin Dong, Yiying Zhang, W. Haas, Zhongcong Xie   +13 more
semanticscholar   +1 more source

Mitochondrial DNA mediates immunoparalysis of dendritic cells in sepsis via STING signalling

Cell Proliferation, Volume 55, Issue 12, December 2022., 2022
Sepsis led to mtDNA accumulation in cytoplasm of DCs. Cytoplasmic mtDNA activated STING signaling to up‐regulate phosphorylation of TBK1, promote the phosphorylation and nuclear translocation of IRF3 to mediate transcription of type I IFNs, which in then triggered the JAK‐STAT3 signaling to up‐regulate the transcription of IL‐10.
Qing Tu, Yi Li, Jiali Zhu, Long Guo, Chenchen Liu, Lu Liu, Yuan Yuan, Yun Zou, Feng Chen, Liangfang Yao, Jinbao Li   +10 more
wiley   +1 more source

PEX5R/Trip8b-HCN2 channel regulating neuroinflammation involved in perioperative neurocognitive disorders

Cell & Bioscience, 2022
Background Clinical and animal studies demonstrated that neuroinflammation from anesthesia (sevoflurane) is the main contributor to cause perioperative neurocognitive disorders (PND).
Feng Xu, Yafeng Wang, Linlin Han, Daling Deng, Yuanyuan Ding, LuLin Ma, Qingtong Zhang, Xiangdong Chen   +7 more
doaj   +1 more source

Mitophagy impairment is involved in sevoflurane-induced cognitive dysfunction in aged rats

Aging, 2020
Postoperative cognitive dysfunction (POCD) is frequently observed in elderly patients following anesthesia, but its pathophysiological mechanisms have not been fully elucidated.
Yeru Chen, Piao Zhang, Xianyi Lin, Huan-yi Zhang, Jiamin Miao, You-fa Zhou, Gang Chen   +6 more
semanticscholar   +1 more source

Resveratrol Mitigates Sevoflurane-Induced Neurotoxicity by the SIRT1-Dependent Regulation of BDNF Expression in Developing Mice

Oxidative Medicine and Cellular Longevity, 2020
Various lines of evidence suggest that neonatal exposure to general anesthetics, especially repeatedly, results in neuropathological brain changes and long-term cognitive impairment.
Xiaole Tang, Yilin Zhao, Zhi-qiang Zhou, Jing Yan, Biyun Zhou, Xiaohui Chi, A. Luo, Shiyong Li   +7 more
semanticscholar   +1 more source

Which Predictor, SctO2 or SstO2, Is more Sensitive for Postoperative Cognitive Dysfunction in Spine Surgery: A Prospective Observational Study?

Orthopaedic Surgery, Volume 15, Issue 1, Page 276-285, January 2023., 2023
The patients with postoperative cognitive dysfunction (POCD) had a higher decrease in intraoperative absolute somatic tissue oxygen saturation (SstO2) decrease (4.9 ± 3.8 vs 3.6 ± 2.6, P = 0.037) (A) and a higher decrease in intraoperative relative SstO2 decrease (7.4 ± 5.6 vs 5.3 ± 3.8, P = 0.036) (B). The proportion below 90% of baseline SstO2 in the
Fei Guo, Shuaiying Jia, Qiyan Wang, Qinyu Liu, Mingquan Hu, Wenzhang Wang, Shijian Liu, Qiang Li, Bin Lu, Yeying Zheng   +9 more
wiley   +1 more source

miRNA‐384‐3p alleviates sevoflurane‐induced nerve injury by inhibiting Aak1 kinase in neonatal rats

Brain and Behavior, 2022
Objective Sevoflurane is a common anesthetic and is widely used in pediatric clinical surgery to induce and maintain anesthesia through inhalation. Increasing studies have revealed that sevoflurane has neurotoxic effects on neurons, apoptosis, and memory
Yuanyuan Chen, Xuan Gao, Hao Pei
doaj   +1 more source