Results 31 to 40 of about 82,704 (334)

The effects of midazolam and sevoflurane on the GABA receptors with alternatively spliced variants of the γ2 subunit [PDF]

Korean Journal of Anesthesiology, 2011
BackgroundEmergence agitation after sevoflurane anesthesia in children can be prevented by midazolam. Alternative splicing of the GABAA receptor changes with age.
Woosik Eom, Jung Min Lee, Jeongmi Park, Kyungho Choi, Sung-Jun Jung, Hee-Soo Kim   +5 more
doaj   +1 more source

Sevoflurane posttreatment prevents oxidative and inflammatory injury in ventilator-induced lung injury. [PDF]

PLoS ONE, 2018
Mechanical ventilation is a life-saving clinical treatment but it can induce or aggravate lung injury. New therapeutic strategies, aimed at reducing the negative effects of mechanical ventilation such as excessive production of reactive oxygen species ...
Julie Wagner, Karl M Strosing, Sashko G Spassov, Ziwei Lin, Helen Engelstaedter, Sabine Tacke, Alexander Hoetzel, Simone Faller   +7 more
doaj   +1 more source

Tau Contributes to Sevoflurane-induced Neurocognitive Impairment in Neonatal Mice

Anesthesiology, 2020
Background: Sevoflurane anesthesia induces Tau phosphorylation and cognitive impairment in neonatal but not in adult mice. This study tested the hypothesis that differences in brain Tau amounts and in the activity of mitochondria–adenosine triphosphate ...
Yang Yu, Yongya Yang, Hong Tan, M. Boukhali, A. Khatri, Yong-Hao Yu, Fuzhou Hua, Ling Liu, Mengzhu Li, Guang Yang, Yuanlin Dong, Yiying Zhang, W. Haas, Zhongcong Xie   +13 more
semanticscholar   +1 more source

Mitophagy impairment is involved in sevoflurane-induced cognitive dysfunction in aged rats

Aging, 2020
Postoperative cognitive dysfunction (POCD) is frequently observed in elderly patients following anesthesia, but its pathophysiological mechanisms have not been fully elucidated.
Yeru Chen, Piao Zhang, Xianyi Lin, Huan-yi Zhang, Jiamin Miao, You-fa Zhou, Gang Chen   +6 more
semanticscholar   +1 more source

Resveratrol Mitigates Sevoflurane-Induced Neurotoxicity by the SIRT1-Dependent Regulation of BDNF Expression in Developing Mice

Oxidative Medicine and Cellular Longevity, 2020
Various lines of evidence suggest that neonatal exposure to general anesthetics, especially repeatedly, results in neuropathological brain changes and long-term cognitive impairment.
Xiaole Tang, Yilin Zhao, Zhi-qiang Zhou, Jing Yan, Biyun Zhou, Xiaohui Chi, A. Luo, Shiyong Li   +7 more
semanticscholar   +1 more source

Sevoflurane suppresses cell viability and invasion and promotes cell apoptosis in colon cancer by modulating exosome-mediated circ-HMGCS1 via the miR-34a-5p/SGPP1 axis

Oncology Report, 2020
As a novel halogenated hydroxyl ether-inhaled general anesthetic, sevoflurane has been reported to affect the progression of diverse human cancers. In the present study, we aimed to explore the functions and underlying mechanisms of sevoflurane in colon ...
Juan He, Huaping Zhao, Xing Liu, Dongmei Wang, Yong Wang, Yanqiu Ai, Jianjun Yang   +6 more
semanticscholar   +1 more source

Sevoflurane exposure may cause dysplasia of dendritic spines and result in fine motor dysfunction in developing mouse through the PI3K/AKT/mTOR pathway

Frontiers in Neuroscience, 2022
Sevoflurane has become one of the most widely used volatile anesthetics in pediatric surgery. However, sevoflurane exposure may interfere with dendritic development and synaptogenesis, resulting in brain function impairment.
Linhong Zhong, Xiaofan Ma, Yixuan Niu, Lei Zhang, Zhenyu Xue, Jia Yan, Hong Jiang   +6 more
doaj   +1 more source

Tracheal intubation without neuromuscular blocking drugs in children [PDF]

, 2009
No abstract ...
Aantaa, Abdallah, Aouad, Batra, Blair, Blair, Bode, Crawford, De Fatima De Assuncao Braga, Drenger, Duman, Gupta, Hansen, Hansen, Helbo-Hansen, Hiller, Humphries, Inomata, Inomata, Inomata, Inomata, Inomata, Klemola, Lerman, Meakin, Mertes, Min, Morgan, Nishina, O’Brien, Politis, Politis, Robinson, Senel, Simon, Splinter, Steyn, Swan, Taguchi, Thwaites, Wappler, Warner, Watcha, Watcha, Watcha, Watcha, Weber, Woods, Xue, Xue, Xue, Xue, Yaguchi   +52 more
core   +1 more source

Influence of the sevoflurane concentration on the occurrence of epileptiform EEG patterns.

PLoS ONE, 2014
Objectives and aimThis study was performed to analyse the effects of different sevoflurane concentrations on the incidence of epileptiform EEG activity during induction of anaesthesia in children in the clinical routine.BackgroundIt was suggested in the ...
Ines Kreuzer, W Alexander Osthaus, Arthur Schultz, Barbara Schultz   +3 more
doaj   +1 more source

Sevoflurane postconditioning improves spatial learning and memory ability involving mitochondrial permeability transition pore in hemorrhagic shock and resuscitation rats

Brain and Behavior, 2020
Background Hemorrhagic shock induces the cognitive deficiency. Sevoflurane postconditioning has been documented to provide neuroprotection against ischemic–reperfusion injury by suppressing apoptosis.
Li Zhang, Li Huang, Jingxian Wang, Muchun Zhang, Ye Zhang, Xianwen Hu   +5 more
doaj   +1 more source