Results 41 to 50 of about 57,547 (259)

Role of TREM1 in the sevoflurane‐induced inflammatory activation of microglia in vitro

Ibrain, EarlyView.
Perioperative neurocognitive disorders (PNDs) are one of the most common complications in perioperative patients, and neuroinflammatory reaction mediated by microglia plays a key role in their formation. Triggering receptor expressed on myeloid cells 1 (TREM1) is a key regulator of inflammation.
Chunchun Tang, Yuhang Zhu, Dexing Liu, Xue Zheng, Junli Jiang, Wanqiu Yu, Yinan Zhang, Dongqin Chen, Zhaoqiong Zhu   +8 more
wiley   +1 more source

Research progress on the depth of anesthesia monitoring based on the electroencephalogram

Ibrain, Volume 11, Issue 1, Page 32-43, Spring 2025.
Electroencephalogram (EEG) can noninvasive, continuous, and real‐time monitor the state of brain electrical activity, and the monitoring of EEG can reflect changes in the depth of anesthesia (DOA). The development of artificial intelligence can enable anesthesiologists to extract, analyze, and quantify DOA from complex EEG data.
Xiaolan He, Tingting Li, Xiao Wang
wiley   +1 more source

5‐HT3 receptor antagonists for preventing postoperative nausea and vomiting after gynecological surgery: A systematic review and network meta‐analysis

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Background Gynecological surgery is generally associated with a high risk of postoperative nausea and vomiting (PONV), for which a combination of antiemetic therapies is advised, but adherence to these protocols is often low. Given the current reality, a preferred 5‐HT3 receptor antagonist for preventing PONV as a result of gynecological ...
Hongxia Xu, Lingyan Rong, Shaohui Yang, Jiankun Xing, Huajun Dong, Huihui Liu, Xiaotao Chen, Lingyan Liu   +7 more
wiley   +1 more source

Unveiling the Therapeutic Potential of Atractylis aristata Batt. Aqueous Extract: Anti‐inflammatory, Antioxidant, Antibacterial, Sedative Activities & Phytochemical Profiling

ChemistryOpen, EarlyView.
This study evaluates the pharmacological properties of the aqueous extract of Atractylis aristata, focusing on its antioxidant, anti‐inflammatory, antibacterial, and sedative activities. Phytochemical analysis identifies bioactive compounds, while in vitro and in vivo tests demonstrate its therapeutic potential in addressing oxidative stress ...
Asma Abid, Nourelhouda Mekhadmi, Randa Mlik, Assia Bentahar, Kamilia Bireche, Bariza Frih, Walid Boussebaa, Aicha Mouane, Nezar Cherrada, Ana Sanches Silva, Messaouda Dekmouche, Lazhar Bechki, Khalid Mashay Al‐Anazi, Mohammad Abul Farah, Ahmad Ali   +14 more
wiley   +1 more source

Dexmedetomidine suppresses sevoflurane anesthesia-induced neuroinflammation through activation of the PI3K/Akt/mTOR pathway

BMC Anesthesiology, 2019
BackgroundSevoflurane, an inhalational general anesthetic, has become one of the most widely used inhalational anesthetics in surgery. However, previous studies have found that sevoflurane anesthesia can trigger an inflammatory response, resulting in ...
Nan Wang, Mingyu Wang
semanticscholar   +1 more source

Sevoflurane induces the inattention, cognitive impairment, and motor dysfunction by hypermethylation of retinoic acid receptor α in the medial prefrontal cortex of neonatal mice

VIEW, EarlyView.
The mechanisms underlying neurodevelopmental toxicity induced by repeated exposure to general anesthesia in neonatal mice remain to be fully elucidated. In this study, neonatal mice were exposed to sevoflurane on postnatal days 6, 8, and 10. On postnatal day 30, the medial prefrontal cortex was collected for whole‐genome bisulfite sequencing and RNA ...
Yu Hou, Shuai Li, Qi Hou, Runjia Wang, Zhenghao Deng, Xiyuan Xu, Zhichao Li, Linhui Ma, Yuan Shen, Qidong Liu, Hui Zheng   +10 more
wiley   +1 more source

Euthanasia of laboratory mice: Are isoflurane and sevoflurane real alternatives to carbon dioxide?

PLoS ONE, 2018
In the European Union (EU) millions of laboratory mice are used and killed for experimental and other scientific purposes each year. Although controversially discussed, the use of carbon dioxide (CO2) is still permitted for killing rodents according to ...
N. Marquardt, Malte Feja, H. Hünigen, J. Plendl, L. Menken, H. Fink, B. Bert   +6 more
semanticscholar   +1 more source

Whatever happened to sevoflurane? [PDF]

Canadian Journal of Anaesthesia, 1992
This issue of the Canadian Journal of Anaesthesia contains the article by Crawford et al. entitled "Haemodynamic and organ blood flow responses to sevoflurane during spontaneous ventilation in the rat: a dose response study." The salient point of the paper is the conclusion that in this model, sevoflurane maintains both cardiovascular stability and ...
Burnell R. Brown, Edward J. Frink
openaire   +3 more sources

Acquired narcolepsy secondary to a presumptive hypothalamic hamartoma in a young German wirehaired pointer dog

Veterinary Record Case Reports, EarlyView.
Abstract A 3‐year‐old, male, entire, German wirehaired pointer dog was presented with a 2‐year history of paroxysmal episodes of collapse associated with reduced levels of consciousness. A magnetic resonance imaging study identified a single, ill‐defined, non‐contrast‐enhancing, intra‐axial mass lesion involving the hypothalamus.
Callum Atkins, Tessa V. Procter, Tobias Schwarz, Megan Madden   +3 more
wiley   +1 more source

Sevoflurane inhibits migration and invasion of colorectal cancer cells by regulating microRNA-34a/ADAM10 axis.

Neoplasma (Bratislava), 2019
Sevoflurane is frequently used volatile anesthetic in cancer surgery. It has been suggested that treatment with sevoflurane could suppress migration and invasion of several human cancer cells in vitro.
S. Sun, L. Ren, J. Liu, P. Wang, S. Shan
semanticscholar   +1 more source