Results 71 to 80 of about 1,582,592 (296)

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Sex Expression and Seed Yield Stability in Thai Hemp (Cannabis sativa L.): Seasonal Effects on Dioecious Cultivars for Optimized Seed Production

International Journal of Plant Biology
This study investigates the environmental regulation of sex expression and seed yield stability in four Thai dioecious hemp (Cannabis sativa L.) cultivars (RPF1, RPF2, RPF3, and RPF4) under different seasonal conditions to optimize seed production.
Pheeraphan Thongplew, Jakkrapong Kangsopa, Sutheera Hermhuk, Krittiya Tongkoom, Prakash Bhuyar, Nednapa Insalud   +5 more
doaj   +1 more source

Transcriptional regulation of dosage compensation in Carica papaya

Scientific Reports, 2021
Sex chromosome evolution results in the disparity in gene content between heterogametic sex chromosomes and creates the need for dosage compensation to counteract the effects of gene dose imbalance of sex chromosomes in males and females. It is not known
Juan Liu, Jennifer Han, Anupma Sharma, Ching Man Wai, Ray Ming, Qingyi Yu   +5 more
doaj   +1 more source

DEFENDING ALL-MALE EDUCATION: A NEW CULTURAL MOMENT FOR A RENEWED DEBATE [PDF]

, 2001
Although all-female schools still prosper and are defended by members of the academic elite, an all-male college has become a near-extinct species. Many people are surprised such a creature still exists.
Webb, Stephen H.
core   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Harnessing natural variation to identify cis regulators of sex-biased gene expression in a multi-strain mouse liver model.

PLoS Genetics, 2021
Sex differences in gene expression are widespread in the liver, where many autosomal factors act in tandem with growth hormone signaling to regulate individual variability of sex differences in liver metabolism and disease.
Bryan J Matthews, Tisha Melia, David J Waxman   +2 more
doaj   +1 more source

Sex significantly influences transduction of murine liver by recombinant adeno-associated viral vectors through an androgen-dependent pathway. [PDF]

, 2003
A systematic evaluation of the influence of sex on transduction by recombinant adeno-associated viral vector (rAAV) indicated that transgene expression after liver-targeted delivery of vector particles was between 5- to 13-fold higher in male mice ...
Davidoff, AM, Nathwani, AC, Ng, CYC, Spence, Y, Zhou, J   +4 more
core   +1 more source

Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines: Prevalence of Germline Recombination and Influencing Factors. [PDF]

, 2020
The Cre-loxP system is invaluable for spatial and temporal control of gene knockout, knockin, and reporter expression in the mouse nervous system. However, we report varying probabilities of unexpected germline recombination in distinct Cre driver lines ...
Abumaria, Nashat, Ambrozkiewicz, Mateusz C, Beier, Kevin T, Benseler, Fritz, Brose, Nils, Burgess, Harold A, Cepko, Constance L, Chen, Cui, Cloutier, Jean-François, Craig, Ann Marie, Dumontier, Emilie, Eroglu, Cagla, Falkner, Susanne, Furlanis, Elisabetta, Goebbels, Sandra, Gomez, Andrea M, Hoshina, Naosuke, Huang, Wei-Hsiang, Hutchison, Mary Anne, Itoh-Maruoka, Yu, Kaeser, Pascal S, Kawabe, Hiroshi, Kay, Jeremy N, Lavery, Laura A, Li, Wei, Lu, Wei, Luo, Lin, Luo, Liqun, Mandai, Kenji, Maruo, Tomohiko, McBain, Chris J, Motohashi, Junko, Nave, Klaus-Armin, Pai, Emily Ling-Lin, Pelkey, Kenneth A, Pereira, Ariane, Philips, Thomas, Prado, Marco AM, Prado, Vania F, Rothstein, Jeffrey, Rubenstein, John LR, Saher, Gesine, Sakimura, Kenji, Sanes, Joshua R, Scheiffele, Peter, Sinclair, Jennifer L, Stogsdill, Jeff A, Takai, Yoshimi, Traunmüller, Lisa, Umemori, Hisashi, Verhage, Matthijs, Wang, Jiexin, Wortel, Joke, You, Wenjia, Yuzaki, Michisuke, Zoghbi, Huda Yahya   +55 more
core   +2 more sources

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source