Genes & Development, 2023 In this study, Zhang et al. provide molecular and structural insights into the cancer-relevant interaction between spliceosome factors SF3B1 and SUGP1. They further elucidate the effect of cancer-associated mutations in SF3B1 and SUGP1 that weaken their ...
Jian Zhang +9 more
semanticscholar +1 more source
Regulation of HPV16 E6 and MCL1 by SF3B1 inhibitor in head and neck cancer cells [PDF]
, 2014 ABT-737 inhibits the anti-apoptotic proteins B-cell lymphoma 2 (BCL-2) and BCL-X L. Meayamycin B switches the splicing pattern of myeloid cell leukemia factor 1 (MCL1) pre-mRNA.
Ferris, RL, Gao, Y, Koide, K, Trivedi, S
core +4 more sources
Nucleic Acids Research, 2023 Transcription-associated cyclin-dependent kinases (CDKs) regulate the transcription cycle through sequential phosphorylation of RNA polymerase II (RNAPII).
V. Panzeri +4 more
semanticscholar +1 more source
Co-targeting HGF/cMET Signaling with MEK Inhibitors in Metastatic Uveal Melanoma. [PDF]
, 2017 Patients with metastatic uveal melanoma usually die within 1 year of diagnosis, emphasizing an urgent need to develop new treatment strategies. The liver is the most common site of metastasis.
Aplin, Andrew E. +8 more
core +2 more sources
A Low Frequency of Losses in 11q Chromosome Is Associated with Better Outcome and Lower Rate of Genomic Mutations in Patients with Chronic Lymphocytic Leukemia [PDF]
, 2015 This work was supported by grants from the Spanish Fondo de Investigaciones Sanitarias FIS09/01543, PI12/00281 and PI15/01471, Instituto de Salud Carlos III (ISCIII), European Regional Development Fund (ERDF) "Una manera de hacer Europa", Proyectos de ...
Hernández Sánchez, María +3 more
core +4 more sources
SF3B1 is a stress-sensitive splicing factor that regulates both HSF1 concentration and activity. [PDF]
PLoS ONE, 2017 The heat shock response (HSR) is a well-conserved, cytoprotective stress response that activates the HSF1 transcription factor. During severe stress, cells inhibit mRNA splicing which also serves a cytoprotective function via inhibition of gene ...
Karen S Kim Guisbert, Eric Guisbert
doaj +1 more source
Expression levels of SF3B3 correlate with prognosis and endocrine resistance in estrogen receptor-positive breast cancer [PDF]
, 2015 De novo or acquired resistance to endocrine therapy limits its utility in a significant number of estrogen receptor-positive (ER-positive) breast cancers.
Badve, Sunil +6 more
core +1 more source
SF3B1 mutation–mediated sensitization to H3B-8800 splicing inhibitor in chronic lymphocytic leukemia
Life Science Alliance, 2023 Understanding the pathogenic mechanisms of SF3B1 mutation can help unravel their contribution in patients’ worse prognosis. The cytotoxic effects and delayed leukemic infiltration induced by H3B-8800 support the potential use of SF3B1 inhibitors as a ...
I. López-Oreja +12 more
semanticscholar +1 more source
The protein kinase DYRK1A phosphorylates the splicing factor SF3b1/SAP155 at Thr434, a novel in vivo phosphorylation site. [PDF]
, 2011 BACKGROUND: The U2 small nuclear ribonucleoprotein particle (snRNP) component SF3b1/SAP155 is the only spliceosomal protein known to be phosphorylated concomitant with splicing catalysis.
Becker, Walter +6 more
core +1 more source
Rare SF3B1 R625 mutations in cutaneous melanoma [PDF]
Melanoma Research, 2014 RNA splicing is the cellular process that has only recently been found to be an important target for various cancers. Among the spliceosome genes that are involved in cancers, SF3B1 is most frequently mutated. Recurrent mutation in codon 625 has been found in uveal melanoma, but this mutation has not been identified in cutaneous melanoma. We used whole-
Yong Kong +2 more
openaire +3 more sources