Results 41 to 50 of about 3,555 (225)

Rapid Spread of Severe Fever with Thrombocytopenia Syndrome Virus by Parthenogenetic Asian Longhorned Ticks [PDF]

, 2022
Publishe
Chandra, S, Cheng, C, Choi, YK, Chu, H, Fan, S, Gedye, K, Han, X, Jenkins, C, Jia, Y, Kanuka, H, Lawrence, K, Li, H, Liu, Q, Price, DC, Sun, J, Tanaka, T, Wang, Y, Yang, Z, Ye, L, Yu, T, Zhan, X, Zhang, G, Zhang, X, Zhang, Z, Zhao, C, Zheng, A   +25 more
core   +1 more source

Severe fever with thrombocytopenia syndrome virus induces platelet activation and apoptosis via a reactive oxygen species-dependent pathway

Redox Biology, 2023
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne infectious disease caused by the SFTS virus (SFTSV) and with a high fatality rate.
Yi-Hui Li, Xue-Hui Wang, Wen-Wu Huang, Ren-Rong Tian, Wei Pang, Yong-Tang Zheng   +5 more
doaj   +1 more source

Mapping of transcription termination within the S segment of SFTS phlebovirus facilitated the generation of NSs-deletant viruses [PDF]

, 2017
SFTS phlebovirus (severe fever with thrombocytopenia syndrome virus; SFTSV) is an emerging tick-borne bunyavirus that was first reported in China in 2009. Here we report the generation of a recombinant SFTSV (rHB29NSsKO) that cannot express the viral non-
Brennan, Benjamin, Elliott, Richard M., Rezelj, Veronica V.   +2 more
core   +1 more source

Infection of humanized mice with a novel phlebovirus presented pathogenic features of severe fever with thrombocytopenia syndrome.

PLoS Pathogens, 2021
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a tick-borne emerging phlebovirus with high mortality rates of 6.0 to 30%. SFTSV infection is characterized by high fever, thrombocytopenia, leukopenia, hemorrhage and multiple organ failures ...
Shijie Xu, Na Jiang, Waqas Nawaz, Bingxin Liu, Fang Zhang, Ye Liu, Xilin Wu, Zhiwei Wu   +7 more
doaj   +1 more source

Construction and Characterization of Severe Fever with Thrombocytopenia Syndrome Virus with a Fluorescent Reporter for Antiviral Drug Screening

Viruses, 2023
Severe fever with thrombocytopenia syndrome (SFTS) caused by a novel bunyavirus (SFTSV) is an emerging infectious disease with up to 30% case fatality. Currently, there are no specific antiviral drugs or vaccines for SFTS. Here, we constructed a reporter
Xiao Wang, Mingyue Xu, Huanhuan Ke, Longda Ma, Liushuai Li, Jiang Li, Fei Deng, Manli Wang, Zhihong Hu, Jia Liu   +9 more
doaj   +1 more source

A viral codon usage strategy enhances antigen production and protection in SFTSV mRNA vaccination. [PDF]

NPJ Vaccines
Cha I, Yamada Y, Kim D, Kang S, Yang WS, Shin WJ, Ryder A, Lewis M, Chung C, Cho NH, Choi YK, Li J, Lai CJ, Jung JU.   +13 more
europepmc   +3 more sources

Knockout of CLTC gene reduces but not completely block SFTSV infection

PLOS ONE, 2023
Clathrin is a key protein for viruses to enter host cells. Previous studies often use clathrin inhibitors or gene knockdown technology to partially inhibit the function of clathrin, but whether SFTSV can infect host cells without clathrin expression remains unclear.
Tiezhu Liu, Jiajia Li, Xueqi Wang, Tao Huang, Wei Wu, Aqian Li, Chuan Li, Xiaoxia Huang, Qin Wang, Dexin Li, Shiwen Wang, Mifang Liang   +11 more
openaire   +3 more sources

Suppression of type I and type III interferon signalling by NSs protein of severe fever-with-thrombocytopenia syndrome virus through inhibition of STAT1 phosphorylation and activation [PDF]

, 2015
Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne pathogen causing significant morbidity and mortality in Asia. NSs protein of SFTSV is known to perturb type I IFN induction and signalling, but the mechanism remains to ...
Chan, CP, Chaudhary, V, Fung, SY, Jin, D, Kok, KH, Li, C, Li, D, Liang, M, Lui, PY, Wang, PH, Yuen, KS, Zhang, S   +11 more
core   +1 more source

Integrated transcriptome profiling in THP-1 macrophages infected with bunyavirus SFTSV

Virus Research, 2021
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a tick-borne bunyavirus that causes an emerging hemorrhagic fever termed SFTS with high mortality. However, knowledge of SFTSV-host interactions is largely limited. Here, we performed a global transcriptome analysis of mRNAs and lncRNAs in THP-1 macrophages infected with SFTSV for 24 and 48 h.
Jia-Min, Yan, Wen-Kang, Zhang, Fei, Li, Chuan-Min, Zhou, Xue-Jie, Yu   +4 more
openaire   +2 more sources

Emerging tick-borne infections in mainland China: an increasing public health threat [PDF]

, 2015
Since the beginning of the 1980s, 33 emerging tick-borne agents have been identified in mainland China, including eight species of spotted fever group rickettsiae, seven species in the family Anaplasmataceae, six genospecies in the complex Borrelia ...
Cao, Wu-Chun, Chen, Wan-Jun, Fang, Li-Qun, Gray, Gregory C., Jiang, Jia-Fu, Krause, Peter J., Li, Hao, Li, Xin-Lou, Liang, Song, Liu, Kun, Liu, Wei, Ma, Mai-Juan, Sun, Ruo-Xi, Sun, Ye, Yang, X. Frank, Yang, Yang, Yao, Hong-Wu, Zuo, Shu-Qing   +17 more
core   +1 more source