Results 71 to 80 of about 47,342 (264)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Asphalted Road Temperature Variations Due to Wind Turbine Cast Shadows

Sensors, 2009
The contribution of this paper is a technique that in certain circumstances allows one to avoid the removal of dynamic shadows in the visible spectrum making use of images in the infrared spectrum.
Jonay Toledo, Marta Sigut, Leopoldo Acosta, Rafael Arnay   +3 more
doaj   +1 more source

Shadows: A Phenomenological Analysis

Phainomenon, 2020
Abstract Shadows are intriguing phenomena. They do not have mass or energy. So, they are unable to have some basic characteristics of the objects of which they are shadows: they cannot move by themselves and they cannot experience the same kind of changes.
openaire   +2 more sources

Shadowing for Pronunciation Development : Haptic-Shadowing and IPA-Shadowing [PDF]

The Journal of AsiaTEFL, 2018
Shadowing was introduced to foreign language teaching in the 1990s and since then it has been researched in EFL teaching contexts. Shadowing has been used as a listening task, and its effectiveness on listening comprehension has been acknowledged. However, its effect on pronunciation development remains unclear.
openaire   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Automatic Cloud and Shadow Detection in Optical Satellite Imagery Without Using Thermal Bands—Application to Suomi NPP VIIRS Images over Fennoscandia

Remote Sensing, 2017
In land monitoring applications, clouds and shadows are considered noise that should be removed as automatically and quickly as possible, before further analysis.
Eija Parmes, Yrjö Rauste, Matthieu Molinier, Kaj Andersson, Lauri Seitsonen   +4 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Single-Image Building Height Estimation Using Spatial Distribution-Aware Optimization in Complex Urban Areas

Remote Sensing
Building height is a fundamental parameter for characterizing urban three-dimensional structure and supporting applications such as urban planning, population estimation, and energy assessment.
Yakun Xie, Jiaxing Tu, Yaoji Zhao, Ruifeng Xia, Wen Song, Dejun Feng, Ya Hu   +6 more
doaj   +1 more source

Language in shadow

Social Neuroscience, 2006
The recent finding that Broca's area, the motor center for speech, is activated during action observation lends support to the idea that human language may have evolved from neural substrates already involved in gesture recognition. Although fascinating, this hypothesis can be questioned because while observing actions of others we may evoke some ...
FADIGA L, CRAIGHERO L, FABBRI DESTRO M, FINOS, LIVIO, COTILLON WILLIAMS N, SMITH AT, CASTIELLO, UMBERTO   +6 more
openaire   +4 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source