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Lipid ciliology: specialized ciliary membrane lipids in physiology and disease. [PDF]
Hasan A +8 more
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GPC6 facilitates progression of SHH-subgroup medulloblastoma by enhancing Hedgehog secretion and signaling responses. [PDF]
Wang Y +13 more
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Rare Endocrine Disorders in Children of Consanguineous Parents: A Case Series. [PDF]
Khaled Ali Abdulla AlKhalifa H +2 more
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Therapeutic Potential of Targeting USP2 in Pediatric Group 3 and 4 Medulloblastomas: Insights from In Silico, Ex Vivo, and In Vitro Studies. [PDF]
da Silva JJ +14 more
europepmc +1 more source
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SHH inhibitors for the treatment of medulloblastoma
Expert Review of Neurotherapeutics, 2015Medulloblastoma is the most common malignant brain tumor of childhood. It is currently stratified into four molecular variants through the advances in transcriptional profiling. They include: wingless, sonic hedgehog (SHH), Group III, and Group IV. The SHH group is characterized by constitutive activation of the SHH signaling pathway, and genetically ...
Ayman, Samkari +2 more
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Nature Immunology, 2004
The regulated expression of Rag genes in lymphocytes ensures the expression of a single antigen receptor on the lymphocyte surface. It now seems that a complex 'ballet' of activating and silencing elements controls the precise timing of Rag expression in thymocytes.
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The regulated expression of Rag genes in lymphocytes ensures the expression of a single antigen receptor on the lymphocyte surface. It now seems that a complex 'ballet' of activating and silencing elements controls the precise timing of Rag expression in thymocytes.
openaire +1 more source

