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Distinct cMET inhibitors uncover pharmacological heterogeneity in SHH medulloblastoma cell lines. [PDF]
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SHH inhibitors for the treatment of medulloblastoma
Expert Review of Neurotherapeutics, 2015Medulloblastoma is the most common malignant brain tumor of childhood. It is currently stratified into four molecular variants through the advances in transcriptional profiling. They include: wingless, sonic hedgehog (SHH), Group III, and Group IV. The SHH group is characterized by constitutive activation of the SHH signaling pathway, and genetically ...
Ayman, Samkari +2 more
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Nature Immunology, 2004
The regulated expression of Rag genes in lymphocytes ensures the expression of a single antigen receptor on the lymphocyte surface. It now seems that a complex 'ballet' of activating and silencing elements controls the precise timing of Rag expression in thymocytes.
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The regulated expression of Rag genes in lymphocytes ensures the expression of a single antigen receptor on the lymphocyte surface. It now seems that a complex 'ballet' of activating and silencing elements controls the precise timing of Rag expression in thymocytes.
openaire +1 more source