Results 111 to 120 of about 4,685,864 (234)

Engineered Nanoplatforms Targeting Activated Hepatic Stellate Cells for Liver Fibrosis Therapy via TGF‐β Axis Inhibition and Ferroptosis Induction

Advanced Healthcare Materials, Volume 15, Issue 37, 9 October 2026.
FeS‐VA@lanifibranor (FVL), an activated hepatic stellate cell (aHSC)‐targeted nanoplatform comprising vitamin A‐functionalized two‐dimensional iron sulfide nanosheets and lanifibranor, is engineered for precision therapy of liver fibrosis. FVL suppresses the TGF‐β signaling pathway by inhibiting SMAD2/3 phosphorylation and induces ferroptosis in aHSCs,
Yinuo Yang, Mengyao Mu, Ke Ren, Hui Liu, Pengju Ma, Yingqi Wang, Mengmeng Zhang, Xueli Xu, Wenzhe Li, Wenshuang Gao, Xiao Sun, Qiang Zhu   +11 more
wiley   +1 more source

PCR Amplification on a Microarray of Gel-Immobilized Oligonucleotides: Detection of Bacterial Toxin- and Drug-Resistant Genes and Their Mutations

BioTechniques, 2000
PCR amplification on a microarray of gel-immobilized primers (microchip) has been developed. One of a pair of PCR primers was immobilized inside a separate microchip polyacrylamide porous gel pad of 0.1 × 0.1 × 0.02 (or 0.04) μm in size and 0.2 (or 0.4 ...
Boris N. Strizhkov, Alexei L. Drobyshev, Vladimir M. Mikhailovich, Andrei D. Mirzabekov   +3 more
doaj   +1 more source

Age‐Dependent Patterns of Cisplatin‐Induced Ototoxicity in Head and Neck Cancer: A Longitudinal Audiologic Analysis

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Background Cisplatin (CDDP) is a key chemotherapeutic agent used to treat head and neck cancer. Improved survival rates have increased concerns about CDDP‐induced ototoxicity, as this toxicity significantly impacts survivors' quality of life. However, the dose‐dependent and age‐related patterns of CDDP‐induced ototoxicity remain incompletely ...
C. Suzuki, Y. Kishimoto, M. Yamamoto, N. Yamamoto, M. Kitamura, S. Hiraoka, R. Nakashima, S. Morita, K. Omori   +8 more
wiley   +1 more source

Shiga Toxin-Associated Hemolytic Uremic Syndrome and Unexpected Course

Turkish Journal of Nephrology, 2019
Hemolytic uremic syndrome is a disease that often requires the transfusion of blood products. A child (two and a half years old, boy) with Shiga toxin-associated hemolytic uremic syndrome who developed respiratory distress after transfusion is presented.
Hakan ERDOĞAN, Gökçe Nur AŞKIN, Şenay MENGİ, Nevin KILIÇ, Mehmet Fatih ORHAN   +4 more
doaj  

Genomic analyses reveal two distinct lineages of Corynebacterium ulcerans strains

New Microbes and New Infections, 2018
Corynebacterium ulcerans is an important zoonotic pathogen which is causing diphtheria-like disease in humans globally. In this study, the genomes of three recently isolated C.
R. Subedi, V. Kolodkina, I.C. Sutcliffe, L. Simpson-Louredo, R. Hirata, Jr., L. Titov, A.L. Mattos-Guaraldi, A. Burkovski, V. Sangal   +8 more
doaj   +1 more source

Long Term Follow Up of Hereditary Thrombotic Thrombocytopenic Purpura on Plasma Therapy for 9 Years: A Case Report

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT A 7.6‐year‐old boy with hTTP had fever‐induced hemorrhagic rash, MAHA, cerebral infarction, and renal impairment. After plasma therapy, symptoms were partially relieved; 9‐year follow‐up showed regular plasma transfusion was needed, with CKD Stage 3.
Dai Xiaomei, Chen Ruyue, Wu Shuang, Tang Hanyun, Lin Qiang, Li Xiaozhong   +5 more
wiley   +1 more source

Shiga Toxin Therapeutics: Beyond Neutralization

Toxins, 2017
Ribotoxic Shiga toxins are the primary cause of hemolytic uremic syndrome (HUS) in patients infected with Shiga toxin-producing enterohemorrhagic Escherichia coli (STEC), a pathogen class responsible for epidemic outbreaks of gastrointestinal disease ...
Gregory Hall, Shinichiro Kurosawa, Deborah J. Stearns-Kurosawa   +2 more
doaj   +1 more source

Adjuvant Antibacterial Effects of Mouriri Elliptica Against Clinical Multidrug Resistant Gram‐Negative Bacterial Strains

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
The ethanolic leaf extract of Mouriri elliptica exhibited antibacterial and antibiofilm activities against multidrug‐resistant clinical isolates and enhanced the activity of ampicillin. Its diverse chemical profile and low acute toxicity support this Cerrado species as a promising source of natural antibacterial adjuvants. ABSTRACT Bacterial resistance
Talita Vilalva Freire, Ana Carolina de Freitas Marques, Valéria dos Santos Gonçalves, Iluska Senna Bonfá Moslaves, Mônica Cristina Toffoli‐Kadri, Arthur Feliciano Camargo da Silva, Martha Janete Giz, Patrícia de Oliveira Figueiredo, Ana Camila Micheletti, Nídia Cristiane Yoshida   +9 more
wiley   +1 more source

Iran's Escherichia coli AMR Landscape (2010–2025): A One Health Systematic Review and Meta‐Analysis

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
This One Health systematic review and meta‐analysis of 368 studies (2010–2025) reveals that 47.2% of E. coli isolates in Iran are ESBL‐producers, with alarming resistance to penicillins, cephalosporins, and fluoroquinolones. Critically, resistance to last‐resort antibiotics—colistin and ertapenem—is significantly increasing over time.
Arezoo Dehghan, Mina Arabian, Zahra Tahmasebi, Aliasghar Fakhri‐Demeshghieh, Neda Baseri, Ehsan Mostafavi, Farzad Badmasti, Faranak Abnaroodhelleh, Arash Seifi, Fahimeh Bagheri Amiri   +9 more
wiley   +1 more source

The Interplay of M1 Macrophages and Dental Pulp Stem Cells Promotes Angiogenesis Through IL‐8‐Dependent VEGF Regulation: An In Vitro Study

International Endodontic Journal, Volume 59, Issue 10, Page 2143-2163, October 2026.
ABSTRACT Background Dental pulp inflammation triggers immune responses involving macrophages and dental pulp stem cells (DPSCs), which interact to regulate angiogenesis essential for tissue repair. M1 pro‐inflammatory macrophages predominate early in pulpitis, and clarifying their angiogenic role is vital in identifying inflammatory regenerative ...
Dineshi Sewvandi Thalakiriyawa, Mohamad Koohi‐Moghadam, Mingxin Hu, Hong Wang, Colman McGrath, Waruna Lakmal Dissanayaka   +5 more
wiley   +1 more source