Results 91 to 100 of about 4,685,864 (234)

454-Pyrosequencing: A Molecular Battiscope for Freshwater Viral Ecology [PDF]

, 2010
Viruses, the most abundant biological entities on the planet, are capable of infecting organisms from all three branches of life, although the majority infect bacteria where the greatest degree of cellular diversity lies.
Allison, Heather E, Woodward, Martin J, Rooks, David, Rooks, D. J., Smith, Darren L, McCarthy, Alan J, McDonald, James E; id_orcid, Woodward, Martin J., Darren L. Smith, Smith, Darren, Rooks, David J, David J. Rooks, Martin J. Woodward, McCarthy, Alan, McCarthy, A. J., Smith, D. L., Heather E. Allison, McDonald, James, Allison, Heather, James E. McDonald, Woodward, Martin, Alan J. McCarthy, McDonald, J. E., Allison, H. E.   +23 more
core   +1 more source

Nanobodies as next‐generation targeting platforms: From discovery technologies to translational biomedicine

VIEW, EarlyView.
Nanobodies, derived from the variable domains of camelid heavy‐chain‐only antibodies, have emerged as transformative biomedical tools due to their nanoscale size, exceptional stability, and unique capacity to recognize cryptic epitopes. This review provides a comprehensive overview of the field, outlining the structural and biochemical features of ...
Zhenrui Ye, Xianyang Li, Meixiao Zhan
wiley   +1 more source

Chemical Synthesis of Shiga Toxin Subunit B Using a Next-Generation Traceless “Helping Hand” Solubilizing Tag [PDF]

, 2019
This manuscript describes the development and characterization of a second-generation "helping hand" solubilizing tag. This semipermanent tag aids solubility of peptides during purification and handling steps and is compatible with common native chemical
Zachary, Cruz, eric, kawamoto, debra, eckert, Mark, Petersen, James, Fulcher, Michael, Kay, J. Nicholas, Francis, Michael, Jacobsen, riley, giesler   +8 more
core   +3 more sources

Targeted Photo‐Induced Elimination of Tumor‐Associated Macrophages Suppresses Cancer Progression in a Murine Model

Cancer Science, EarlyView.
This study demonstrates the selective depletion of tumor‐associated macrophages (TAMs) by targeting CSF1R through near‐infrared photoimmunotherapy (NIR‐PIT). Using a combination of anti‐CSF1R Fab‐IR700 conjugates and localized light irradiation, we achieved tumor suppression and durable antitumor immunity without systemic toxicity.
Kohei Nakajima, Tomomi Uchiyama, Kazuki Funayama, Yuto Goto, Akari Mukaimine, Naoya Ieda, Mikako Ogawa   +6 more
wiley   +1 more source

Inborn errors of immunity in children with neuroinflammation

Developmental Medicine &Child Neurology, EarlyView.
Abstract Inborn errors of immunity (IEIs), an expanding group of monogenic disorders with diverse clinical manifestations, are increasingly recognized to include neuroinflammatory disease. Examples of diseases included under this umbrella are Aicardi–Goutières syndrome, deficiency of adenosine deaminase 2, familial haemophagocytic lymphohistiocytosis ...
Eppie M Yiu, Dilan Dissanayake, Jessie Cunningham, Helen Branson, Ori Scott, E Ann Yeh   +5 more
wiley   +1 more source

Iloperidone treatment mitigates the Juvenile Huntington's Disease phenotype possibly via Sigma‐1 Receptor Modulation

The FEBS Journal, EarlyView.
We investigated the potential of iloperidone as an activator of Sigma‐1 receptor (S1R) neuroprotective function in juvenile Huntington's disease (jHD). We tested iloperidone on cortical neurons differentiated from patient‐derived iPSCs, demonstrating that it acts as a S1R agonist, decreasing apoptosis, huntingtin aggregation, and oxidative stress ...
Ersilia Fornetti, Gaia Galluzzi, Mario Frezzini, Cécile Exertier, Vittorio Brufani, Gianni Colotti, Giancarlo Ruocco, Jessica Rosati, Angelo Luigi Vescovi, Daniele Narzi, Ilaria Genovese, Andrea Ilari   +11 more
wiley   +1 more source

Trafficking of Shiga toxin/Shiga-like toxin-1 in human glomerular microvascular endothelial cells and human mesangial cells. [PDF]

, 2006
Item does not contain fulltextThis study has determined the intracellular transport route of Shiga-like toxin (Stx) and the highly related Shiga toxin in human glomerular microvascular endothelial cells (GMVECs) and mesangial cells.
Monnens, L., L. Monnens, Romer, W., Ludger, Johannes, Heuvel, L.P.W.J. van den, M. Amessou, Römer, Winfried, Lesieur, J., J. Geelen, L. van den Heuvel, Amessou, M., van den Heuvel, L., Amessou, Mohamed, Warnier, M., Geelen, J.M., J. Lesieur, Monnens, L.A.H., Geelen, J., M. Warnier, Lesieur, Julie, Heuvel, Lambertus P. W. J. van den, L. Johannes, W. Römer, Johannes, L.   +23 more
core   +1 more source

Diarrheagenic E. coli in hospitalized patients: Special reference to Shiga-like toxin producing Escherichia coli

Indian Journal of Pathology and Microbiology, 2010
Purpose: This study was conducted to study the prevalence of diarrheagenic Escherichia coli (DEC) in dysentery cases with special reference to Shiga-like toxin producing Escherichia coli (STEC).
Lanjewar Mrudul, De Anuradha, Mathur M
doaj  

Shiga Toxins and the Pathophysiology of Hemolytic Uremic Syndrome in Humans and Animals

Toxins, 2012
Food-borne diseases are estimated at 76 million illnesses and 5000 deaths every year in the United States with the greatest burden on young children, the elderly and immunocompromised populations.
Deborah J. Stearns-Kurosawa, Shinichiro Kurosawa, Caitlin S. Leibowitz, Chad L. Mayer   +3 more
doaj   +1 more source

Ligand binding represses bacterial histidine kinase activity by inhibiting its dimerization

The FEBS Journal, EarlyView.
PdtaS is a kinase in the pathogen Mycobacterium tuberculosis that senses copper and nitric oxide and controls virulence gene expression, but how the kinase senses these compounds was unclear. We show that PdtaS is active as a dimer with each monomer phosphorylating the other in trans.
Gaurav D. Sankhe, Jiawei Xing, Xiansha Xiao, John A. Buglino, Huilin Li, Igor B. Zhulin, Michael S. Glickman   +6 more
wiley   +1 more source