Results 101 to 110 of about 22,481 (247)

Prospective Trial on Tolerability and Efficacy of Adjuvant Nedaplatin Plus Docetaxel for Non‐Small Cell Lung Cancer

Cancer Science, EarlyView.
The flow of this trial and the treatment schedule of adjuvant chemotherapy with nedaplatin plus docetaxel for completely resected non‐small cell lung cancer (NSCLC) (A). The primary endpoint of this study was tolerability, assessed by the completion rate of the planned four chemotherapy cycles. As a result, it was 74.3%, exceeding that reported for the
Koji Teramoto, Ryosuke Kaku, Tomoyuki Igarashi, Masayuki Hashimoto, Shoji Kitamura, Makoto Motoishi, Yuji Suzumura, Satoru Sawai, Yataro Daigo, Jun Hanaoka   +9 more
wiley   +1 more source

Glomerular Endothelial Cell Injury Mediated by Shiga-Like Toxin-1

Kidney and Blood Pressure Research, 1998
The hemolytic uremic syndrome is an important cause of acute renal failure and is often associated with prior infection with enterotoxigenic strains of <i>Escherichia coli.</i> Significant pathologic changes in the glomerulus include endothelial cell swelling, detachment, and intravascular coagulation.
S, Adler, R, Bollu
openaire   +2 more sources

A Three‐Dimensional Culture–Drug Sensitivity Test Predicts MDM2 Inhibitor–Sensitivity in SMARCB1/INI1‐Deficient Tumors

Cancer Science, EarlyView.
This study aimed to determine whether personalized selection of effective drugs for SMARCB1/INI1‐deficient tumors is feasible using in vitro drug sensitivity profiling. Drug sensitivity was assessed using a short‐term collagen gel–embedded three‐dimensional drug sensitivity test (3D‐DST) in tumors derived from SMARCB1/INI1‐deficient tumor cell line ...
Hiroaki Goto, Chiyoko Nishime, Takashi Ohtsu, Mieko Ito, Maiko Sagisaka, Takuya Naruto, Norihiko Kitagawa, Mio Tanaka, Masakatsu Yanagimachi, Yukihiko Hiroshima, Junko Takita, Yasuhide Hayashi, Yohei Miyagi   +12 more
wiley   +1 more source

Inborn errors of immunity in children with neuroinflammation

Developmental Medicine &Child Neurology, EarlyView.
Abstract Inborn errors of immunity (IEIs), an expanding group of monogenic disorders with diverse clinical manifestations, are increasingly recognized to include neuroinflammatory disease. Examples of diseases included under this umbrella are Aicardi–Goutières syndrome, deficiency of adenosine deaminase 2, familial haemophagocytic lymphohistiocytosis ...
Eppie M Yiu, Dilan Dissanayake, Jessie Cunningham, Helen Branson, Ori Scott, E Ann Yeh   +5 more
wiley   +1 more source

Phylogenetic analysis of Shiga toxin 1 and Shiga toxin 2 genes associated with disease outbreaks-0

, 2011
Copyright information:Taken from "Phylogenetic analysis of Shiga toxin 1 and Shiga toxin 2 genes associated with disease outbreaks"http://www.biomedcentral.com/1471-2180/7/109BMC Microbiology 2007;7():109-109.Published online 4 Dec 2007PMCID:PMC2211750.
Larry D Farrell (66913), Peter P Sheridan (27773), James E Lee (66909), Junelina Reed (66910), Malcolm S Shields (66911), Kathleen M Spiegel (66912)   +5 more
core   +1 more source

Shiga Toxin Genes Detected in Fecal Samples of Illinois Finisher Pigs

Bacteria
(1) Background: Pigs can be another host of Shiga toxin-producing E. coli (STEC), suggesting that pork products could be a potential risk to public health. A USDA National Animal Health Monitoring System (NAHMS) study revealed that Shiga toxin genes were
Kathryn L. Lauder, Shafiullah M. Parvej, Yiyang Shen, Chongyang Zhang, Jehadi Osei-Bonsu, James F. Lowe, Weiping Zhang   +6 more
doaj   +1 more source

A new branch of mammalian vitamin B6 metabolism: AKR1C‐mediated conversion of pyridoxal to pyridoxine and 4‐pyridoxolactone

The FEBS Journal, EarlyView.
Pyridoxal 5′‐phosphate (PLP) homeostasis relies on salvage enzymes, yet key metabolic branches remain undefined. We identify AKR1C isozymes as previously undescribed contributors that convert pyridoxal into pyridoxine or 4‐pyridoxolactone through reductase and dehydrogenase activities.
Nayu Kito, Yasuyuki Kitaura, Kyoka Iino, Kazuya Toriumi, Hyunah Noh, Naoya Ogawa, Makoto Arai, Hisashi Hemmi, Tomokazu Ito   +8 more
wiley   +1 more source

Phylogenetic analysis of Shiga toxin 1 and Shiga toxin 2 genes associated with disease outbreaks-7

, 2011
Copyright information:Taken from "Phylogenetic analysis of Shiga toxin 1 and Shiga toxin 2 genes associated with disease outbreaks"http://www.biomedcentral.com/1471-2180/7/109BMC Microbiology 2007;7():109-109.Published online 4 Dec 2007PMCID:PMC2211750.
Larry D Farrell (66913), Peter P Sheridan (27773), James E Lee (66909), Junelina Reed (66910), Malcolm S Shields (66911), Kathleen M Spiegel (66912)   +5 more
core   +1 more source

Microangiopathic Anemia without Thrombocytopenia and Kidney Disease in a Child with Diarrhea Caused by Shiga Toxin–Producing Escherichia coli [PDF]

, 2004
A child with a history of diarrhea presented with transient anemia, reticolucytosis, and red blood cell fragmentation. Blood pressure and levels of blood platelets, creatinine, and urea were normal, as were results of urinalysis.
Rudin, C., von der Weid, N. X., Rudin, Christoph, Meier, P. W., Bianchetti, Mario G., Bianchetti, M. G., Meier, Paul W., Pachlopnik, Jana M., Von Der Weid, Nicolas X., Pachlopnik, J. M.   +9 more
core   +1 more source

Degradomics for large‐scale mechanistic insights on proteases and proteolysis in human health

The FEBS Journal, EarlyView.
Proteolysis has an important role in human disease but remains relatively unexplored. Degradomics, the uncovering of proteolysis in tissues, cells, and proteins, uses mass spectrometry‐based terminomics to identify protein termini occurring therein (forward degradomics) and to define the actions of proteases (reverse degradomics).
Daniel R. Martin, Sumit Bhutada, Suneel S. Apte   +2 more
wiley   +1 more source