Results 81 to 90 of about 22,481 (247)

Structure-Activity Relationship Studies of Retro-1 Analogues Against Shiga Toxin

, 2020
The Retro-1 molecule was identified in a high-throughput screening as an inhibitor of ricin and Shiga toxins by diminishing their intracellular trafficking via the retrograde route, from early endosomes to the Golgi apparatus.
Valérie, Pons, David-Alexandre, Buisson, Jean-Christophe, Cintrat, Daniel, Gillet, Lilia, Ait Ouarab, Lucie, Caramelle, Aurélien, Michau, Julien, Barbier, Hajer, Abdelkafi, Flora, Ngadjeua, Alexandra, Clerget   +10 more
core   +1 more source

The effect of two ribonucleases on the production of Shiga toxin and stx-bearing bacteriophages in Enterohaemorrhagic Escherichia coli

Scientific Reports, 2021
Enterohaemorrhagic Escherichia coli (EHEC) comprise a group of intestinal pathogens responsible for a range of illnesses, including kidney failure and neurological compromise.
Patricia B. Lodato
doaj   +1 more source

Non-O157 Shiga toxin-producing Escherichia coli with potential harmful profiles to humans are isolated from the faeces of calves in Uruguay

Austral Journal of Veterinary Sciences, 2022
Shiga toxin-producing Escherichia coli (STEC) infections are responsible for acute illnesses and deaths in humans. Cattle and humans are exposed to STEC through faeces and contaminated food and water.
Ana Umpiérrez, Déborah Ernst, Andrea Cardozo, Alexia Torres, Magalí Fernández, Martín Fraga, Rafael Vignoli, Inés Bado, Roberto Vidal, Pablo Zunino   +9 more
doaj   +1 more source

The A1 Subunit of Shiga Toxin 2 Has Higher Affinity for Ribosomes and Higher Catalytic Activity than the A1 Subunit of Shiga Toxin 1 [PDF]

Infection and Immunity, 2016
ABSTRACT Shiga toxin (Stx)-producing Escherichia coli (STEC) infections can lead to life-threatening complications, including hemorrhagic colitis (HC) and hemolytic-uremic syndrome (HUS), which is the most common cause of acute renal failure in children in the United States.
Debaleena, Basu, Xiao-Ping, Li, Jennifer N, Kahn, Kerrie L, May, Peter C, Kahn, Nilgun E, Tumer   +5 more
openaire   +2 more sources

Microbial communities and functional diversity in seafood

JSFA reports, EarlyView.
Abstract Functional diversity encompasses ecosystem processes that enhance adaptability to environmental change. This study explores the diversity of microorganisms associated with seafood. In this paper, we present our knowledge of microbial diversity in relation to seafood.
Christian Larbi Ayisi, Samuel Ayeh Osei, Grace Afumwaa Boamah, Gertrude Dzifa Mensah   +3 more
wiley   +1 more source

Integrative Modular, Network-Based, and Machine Learning Framework for Predicting Accessory Genome Functions and Virulence in Escherichia coli O157:H7. [PDF]

Microbiologyopen
An analysis of the accessory genomes from 77 Escherichia coli O157:H7 strains using network and machine learning techniques uncovers modular communities of plasmid‐related virulence associated with IncF replicons. Accessory markers that are not directly linked to toxin genes can effectively predict the virulence status with an AUC of 0.85, facilitating
Gambushe SM, Zishiri OT.
europepmc   +2 more sources

Multimodal targets of (‐)‐α‐thujone mediating avoidance behavior of a stored‐products pest, Tribolium castaneum, in response to irritant stimuli

Pest Management Science, EarlyView.
We identified four kinds of target molecules against (‐)‐α‐thujone associating avoidance behavior in Tribolium castaneum, indicating multimodality. Abstract BACKGROUND The reciprocal evolutionary processes among phytophagous insects and host plants involve host shift in the herbivorous insects in response to defense chemicals, such as plant‐derived ...
Kenji Shimomura, Yuto Suzuki, Soshi Ino, Takehito Terajima, Motohiro Tomizawa   +4 more
wiley   +1 more source

Presence of Non – O157 Shiga Toxin Producing Escherichia coli in Broiler chickens [PDF]

Egyptian Journal of Animal Health, 2023
Shiga toxin (Stx)-producing E. coli (STEC) is one of the most important pathogens that infected broiler chickens and cause large economic loses in Egypt broiler farms. The present study was designed to determine the prevalence and identification of Non –
doaj   +1 more source

Epx4 Nanopore With Multiple Constrictions for Single‐Molecule Identification

Small Methods, EarlyView.
Epx4 is a biological multi‐constriction nanopore that generates informative current signals for polypeptide sensing. Compared with α‐hemolysin, Epx4 detects short poly‐L‐lysine (S‐PLL, Mw 10 kDa) at a higher event frequency and produces signal features that distinguish it from long poly‐L‐lysine (L‐PLL, Mw 30–70 kDa), with an ROC AUC of 0.82 for the ...
Ayako Ijuin, Kota Naito, Mana Sato, Virginia Di Toro Mammarella, Nanami Takeuchi, Mauro Chinappi, Yoshikazu Tanaka, Ryuji Kawano   +7 more
wiley   +1 more source

Shiga-Like Toxin Produced by Local Isolates of O157:H7 Induces Apoptosis of the T47 Breast Cancer Cell Line

Breast Cancer: Basic and Clinical Research, 2021
Purpose: It has been suggested that Shiga-like toxins produced by Escherichia coli O157:H7 could be used as novel therapeutic agents against malignant tumors. In addition, the antitumor potency of local isolates from Indonesia, which are known to be less
Komang Januartha Putra Pinatih, I Wayan Suardana, Dyah Ayu Widiasih, Hamong Suharsono   +3 more
doaj   +1 more source