Results 21 to 30 of about 22,481 (247)

Safety and Pharmacokinetics of Chimeric Anti-Shiga Toxin 1 and Anti-Shiga Toxin 2 Monoclonal Antibodies in Healthy Volunteers [PDF]

Antimicrobial Agents and Chemotherapy, 2009
ABSTRACT Shiga toxin (Stx)-producing Escherichia coli (STEC) causes hemorrhagic colitis and hemolytic-uremic syndrome (HUS). The rates of STEC infection and complications, including death, are highest among young children and elderly individuals. There are no causal therapies.
Martin, Bitzan, Ruth, Poole, Mariam, Mehran, Eric, Sicard, Catherine, Brockus, Claire, Thuning-Roberson, Marc, Rivière   +6 more
openaire   +2 more sources

Shiga toxin 1 is more dependent on the P proteins of the ribosomal stalk for depurination activity than Shiga toxin 2 [PDF]

The International Journal of Biochemistry & Cell Biology, 2011
Shiga toxins produced by Escherichia coli O157:H7 are responsible for food poisoning and hemolytic uremic syndrome (HUS). The A subunits of Shiga toxins (Stx1A and Stx2A) inhibit translation by depurinating a specific adenine in the large rRNA. To determine if Stx1A and Stx2A require the ribosomal stalk for depurination, their activity and cytotoxicity
Jia-Chi, Chiou, Xiao-Ping, Li, Miguel, Remacha, Juan P G, Ballesta, Nilgun E, Tumer   +4 more
openaire   +2 more sources

Trafficking of Shiga toxin/Shiga-like toxin-1 in human glomerular microvascular endothelial cells and human mesangial cells [PDF]

Kidney International, 2006
This study has determined the intracellular transport route of Shiga-like toxin (Stx) and the highly related Shiga toxin in human glomerular microvascular endothelial cells (GMVECs) and mesangial cells. In addition, the effect of tumor necrosis factor-alpha (TNF-alpha), which contributes to the pathogenesis of hemolytic-uremic syndrome, was evaluated ...
Warnier, M., Römer, Winfried, Geelen, J., Lesieur, Julie, Amessou, Mohamed, Heuvel, Lambertus P. W. J. van den, Monnens, L., Ludger, Johannes   +7 more
openaire   +4 more sources

Inhibition of development of Shiga toxin-converting bacteriophages by either treatment with citrate or amino acid starvation [PDF]

, 2012
Objectives: Shiga toxin–producing Escherichia coli (STEC) are pathogenic strains, whose virulence depends on induction of Shiga toxin–converting prophages and their subsequent lytic development.
Bożena Nejman-Faleńczyk, Grzegorz Węgrzyn, Maciąg, Monika, Alicja Wegrzyn, Węgrzyn, Alicja, Węgrzyn, Grzegorz, Golec, Piotr, Nejman-Faleńczyk, Bożena, Monika Maciąg, Piotr Golec   +9 more
core   +1 more source

Toxicity of Shiga Toxin 1 in the Central Nervous System of Rabbits [PDF]

Infection and Immunity, 2001
ABSTRACT The action of Shiga toxin (Stx) on the central nervous system was examined in rabbits. Intravenous Stx1 was 44 times more lethal than Stx2 and acted more rapidly than Stx2. However, Stx1 accumulated more slowly in the cerebrospinal fluid than did Stx2.
J, Fujii, Y, Kinoshita, T, Yutsudo, H, Taniguchi, T, Obrig, S I, Yoshida   +5 more
openaire   +2 more sources

Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways [PDF]

, 2007
Rab family guanosine triphosphatases (GTPases) together with their regulators define specific pathways of membrane traffic within eukaryotic cells. In this study, we have investigated which Rab GTPase-activating proteins (GAPs) can interfere with the ...
Evelyn Fuchs, Francis A. Barr, Yoshimura, S. I., Spooner, Robert A., Haas, A. K., Robert A. Spooner, Shin-ichiro Yoshimura, Hass, Alexander K., Fuchs, Evelyn, Lord, Mike, Barr, F. A., Fuchs, E., Lord, J. M., Haas, Alexander K., Spooner, R. A., J. Michael Lord, Alexander K. Haas, Yoshimura, Shin-ichiro, Barr, Francis A.   +18 more
core   +1 more source

Targeting the Early Endosome-to-Golgi Transport of Shiga Toxins as a Therapeutic Strategy

Toxins, 2020
Shiga toxin (STx) produced by Shigella and closely related Shiga toxin 1 and 2 (STx1 and STx2) synthesized by Shiga toxin-producing Escherichia coli (STEC) are bacterial AB5 toxins.
Danyang Li, Andrey Selyunin, Somshuvra Mukhopadhyay   +2 more
doaj   +1 more source

Detection of E. coli O157:H7 and Shigella dysenteriae toxins in clinical samples by PCR-ELISA

Brazilian Journal of Infectious Diseases, 2015
Shiga toxin producing bacteria are potential causes of serious human disease such as hemorrhagic colitis, severe inflammations of ileocolonic regions of gastrointestinal tract, thrombocytopenia, septicemia, malignant disorders in urinary ducts, hemolytic
Jafar Amani, Askary Ahmadpour, Abbas Ali Imani Fooladi, Shahram Nazarian   +3 more
doaj   +1 more source

Characterization of a Shiga‐Toxin 1‐Resistant Stock of Vero Cells [PDF]

Microbiology and Immunology, 2004
AbstractShiga toxins (Stxs, also referred to as verotoxins) were first described as a novel cytotoxic activity against Vero cells. In this study, we report the characterization of an Stx1‐resistant (R‐) stock of Vero cells. (1) When the susceptibility of R‐Vero cells to Stx1 cytotoxicity was compared to that of Stx1‐sensitive (S‐) Vero cells by ...
Takaomi, Sekino, Nobutaka, Kiyokawa, Tomoko, Taguchi, Hisami, Takenouchi, Jun, Matsui, Wei-Ran, Tang, Toyo, Suzuki, Hideki, Nakajima, Masahiro, Saito, Kazuhiro, Ohmi, Yohko U, Katagiri, Hajime, Okita, Hiroshi, Nakao, Tae, Takeda, Junichiro, Fujimoto   +14 more
openaire   +2 more sources

Shiga Toxin 1 Causes Direct Renal Injury in Rats [PDF]

Infection and Immunity, 2005
ABSTRACT Infection with Shiga toxin (Stx)-producing Escherichia coli has been implicated to cause hemolytic uremic syndrome, which is characterized by histological abnormalities such as microvascular thrombi and tubular cell damage in the kidney.
Elise T, Yamamoto, Masashi, Mizuno, Kiyotaka, Nishikawa, Shinobu, Miyazawa, Lianshan, Zhang, Seiichi, Matsuo, Yasuhiro, Natori   +6 more
openaire   +2 more sources